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Single Cell Animation

HIV Vis Aid

Single Cell Animation, llc

Next Image Title

Artist Name

HIV - Human Immunodeficiency Virus destroys the Tcells of the immune system, eventually leading to AIDS.

singlecell animation

Single Cell Animation, llc

medical illustration of Showing plaque buildup within the Artery wall. medical illustration of Showing plaque buildup within the Artery wall.

Plaque Buildup

Showing plaque buildup within the Artery wall.

Keywords: 3D, Advertising / Marketing, Education, Patient Education, Publishing, Anatomy, Disease Management, General Medicine, Medical Devices, Vascular Surgery

© singlecell animation

Single Cell Animation, llc

medical illustration of HIV - Human Immunodeficiency Virus destroys the T cells of the immune system, eventually leading to AIDS. medical illustration of HIV - Human Immunodeficiency Virus destroys the T cells of the immune system, eventually leading to AIDS.

Human Immunodeficiency Virus

HIV - Human Immunodeficiency Virus destroys the T cells of the immune system, eventually leading to AIDS.

Keywords: 3D, Advertising / Marketing, Editorial, Patient Education, Publishing, Allergy / Immunology, Biology, General Medicine, Molecular Biology, Health & Wellness

singlecell animation

Single Cell Animation, llc

medical animation of An animation showing the moving parts of the Respiratory System. The Lungs are different from one another. The right consists of three lobes, Superior, Middle, and Inferior, while the left only has two, the Superior and Inferior.

Respiratory System Animation

An animation showing the moving parts of the Respiratory System. The Lungs are different from one another. The right consists of three lobes, Superior, Middle, and Inferior, while the left only has two, the Superior and Inferior.

Keywords: Animation, Advertising / Marketing, Editorial, Education, Multimedia, Professional Education, Anatomy, Respiratory, Health & Wellness

singlecell animation

Single Cell Animation, llc

medical animation of A time lapse of Melanoma growing over a 3 month period.

Melanoma Timelapse

A time lapse of Melanoma growing over a 3 month period.

Keywords: Animation, Apps/Mobile, Advertising / Marketing, Patient Education, Web, Biology, Dermatology, Oncology, Mechanism of Action (MOA), Health & Wellness

singlecell animation

Single Cell Animation, llc

medical animation of An animation of an 8 week embryo inside the womb.

Embryo Animation

An animation of an 8 week embryo inside the womb.

Keywords: Animation, 3D, Advertising / Marketing, Education, Multimedia, Anatomy, Embryology, Maternal / Child, Natural Science / Nature, Pediatrics

© singlecell animation

Single Cell Animation, llc

medical animation of It takes approximately 1 minute for the heart to circulate 4-5 quarts of blood around the body - back to the heart.

Blood Flow Animation

It takes approximately 1 minute for the heart to circulate 4-5 quarts of blood around the body - back to the heart.

Keywords: Animation, Color, 3D, Live Action Video, Advertising / Marketing, Multimedia, Patient Education, Web, Product Demonstration, Biology, Hemophilia

© singlecell animation

Single Cell Animation, llc

medical illustration of Prescription drugs are made to cure, treat, and prevent disease in many interesting ways. Most medicines today are artificially produced by scientific study and testing. Scientists can isolate all the useful chemicals from plants and animals and over time produce a drug targeted to a particular ailment. medical illustration of Prescription drugs are made to cure, treat, and prevent disease in many interesting ways. Most medicines today are artificially produced by scientific study and testing. Scientists can isolate all the useful chemicals from plants and animals and over time produce a drug targeted to a particular ailment.

Modern Medicine

Prescription drugs are made to cure, treat, and prevent disease in many interesting ways. Most medicines today are artificially produced by scientific study and testing. Scientists can isolate all the useful chemicals from plants and animals and over time produce a drug targeted to a particular ailment.

Keywords: Animation, 3D, Live Action Video, Advertising / Marketing, Editorial, Education, Product Demonstration, Allergy / Immunology, Alternative Medicine, Biology, Cell biology / Histology, Disease Management, Emergency Medicine, General Medicine, Pharmacology

© singlecell animation

Single Cell Animation, llc

medical illustration of Melanoma is a skin cancer developing within the melanocytes (pigment cells). This form of skin cancer may spread to other parts of the body (metastasize), potentially causing a serious illness or death. What is cancer? It’s a group of abnormal cells dividing uncontrollably, eventually becoming a tumor. medical illustration of Melanoma is a skin cancer developing within the melanocytes (pigment cells). This form of skin cancer may spread to other parts of the body (metastasize), potentially causing a serious illness or death. What is cancer? It’s a group of abnormal cells dividing uncontrollably, eventually becoming a tumor.

Skin Cancer

Melanoma is a skin cancer developing within the melanocytes (pigment cells). This form of skin cancer may spread to other parts of the body (metastasize), potentially causing a serious illness or death. What is cancer? It’s a group of abnormal cells dividing uncontrollably, eventually becoming a tumor.

Keywords: Animation, Color, 3D, Advertising / Marketing, Editorial, Education, Multimedia, Product Demonstration, Professional Education, Dermatology, Disease Management

© singlecell animation

Single Cell Animation, llc

medical illustration of The human body is made up of 11 organ systems, each doing a specific job. medical illustration of The human body is made up of 11 organ systems, each doing a specific job.

Glass Anotomy

The human body is made up of 11 organ systems, each doing a specific job.

Keywords: Animation, Design, 3D, Models, Advertising / Marketing, Editorial, Education, Anatomy

© singlecell animation

Single Cell Animation, llc

medical illustration of Some fun experimenting with metal textures and realistic lighting. medical illustration of Some fun experimenting with metal textures and realistic lighting.

Eye | Pathology

Some fun experimenting with metal textures and realistic lighting.

Keywords: Color, 3D, Live Action Video, Advertising / Marketing, Editorial, Multimedia, Web, Anatomy, General Surgery, Injuries

© singlecell animation

Single Cell Animation, llc

medical illustration of These are Kinesin (a motor protein), and we are watching them walk along tracks (Microtubule) inside the cell. Their job is to tug along sacks (vesicles) filled with materials to be excreted from the cell. In this case, they are simply walking all the cell’s waste to the membrane, where it’s discarded outside of the cell. medical illustration of These are Kinesin (a motor protein), and we are watching them walk along tracks (Microtubule) inside the cell. Their job is to tug along sacks (vesicles) filled with materials to be excreted from the cell. In this case, they are simply walking all the cell’s waste to the membrane, where it’s discarded outside of the cell.

Kinesin

These are Kinesin (a motor protein), and we are watching them walk along tracks (Microtubule) inside the cell. Their job is to tug along sacks (vesicles) filled with materials to be excreted from the cell. In this case, they are simply walking all the cell’s waste to the membrane, where it’s discarded outside of the cell.

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Cell biology / Histology, Molecular Biology

© singlecell animation

Single Cell Animation, llc

medical illustration of upon entering the egg, the outer shell seals up, the head of the sperm unites with the nucleus of the egg, and within days.. A single cell will multiply, and keep multiplying to eventually form an embryo. medical illustration of upon entering the egg, the outer shell seals up, the head of the sperm unites with the nucleus of the egg, and within days.. A single cell will multiply, and keep multiplying to eventually form an embryo.

Reproduction

upon entering the egg, the outer shell seals up, the head of the sperm unites with the nucleus of the egg, and within days.. A single cell will multiply, and keep multiplying to eventually form an embryo.

Keywords: Animation, Color, Caricature, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Cell biology / Histology, Embryology, Maternal / Child, Reproductive Biology

© singlecell animation

Single Cell Animation, llc

medical illustration of A Macrophage is part of the immune system. They patrol around the body, entering affected areas, engulfing and destroying bacteria and other pathogens. They also act as a janitor, cleaning up dead cells and other debris around the body, keeping it clean and healthy. medical illustration of A Macrophage is part of the immune system. They patrol around the body, entering affected areas, engulfing and destroying bacteria and other pathogens. They also act as a janitor, cleaning up dead cells and other debris around the body, keeping it clean and healthy.

Macrophage

A Macrophage is part of the immune system. They patrol around the body, entering affected areas, engulfing and destroying bacteria and other pathogens. They also act as a janitor, cleaning up dead cells and other debris around the body, keeping it clean and healthy.

Keywords: Animation, Color, Design, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Allergy / Immunology, Biology, Biotechnology, Cell biology / Histology, Disease Management

© singlecell animation

Single Cell Animation, llc

medical illustration of This is a human embryo at approximately 8 weeks old inside a woman’s womb. The amniotic sac protects the growing baby while the organs and muscles are beginning to work. medical illustration of This is a human embryo at approximately 8 weeks old inside a woman’s womb. The amniotic sac protects the growing baby while the organs and muscles are beginning to work.

Embryo

This is a human embryo at approximately 8 weeks old inside a woman’s womb. The amniotic sac protects the growing baby while the organs and muscles are beginning to work.

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Multimedia, Product Demonstration, Anatomy, Embryology, Maternal / Child, Natural Science / Nature

© singlecell animation

Single Cell Animation, llc

medical illustration of red blood cells carry and deliver packages of oxygen to all the organs throughout the body. Red blood cells are made in the bone marrow and circulate the body for around 4 months before dying, and it's the iron in the blood mixing with the oxygen that’s gives it the red color. medical illustration of red blood cells carry and deliver packages of oxygen to all the organs throughout the body. Red blood cells are made in the bone marrow and circulate the body for around 4 months before dying, and it's the iron in the blood mixing with the oxygen that’s gives it the red color.

Blood

red blood cells carry and deliver packages of oxygen to all the organs throughout the body. Red blood cells are made in the bone marrow and circulate the body for around 4 months before dying, and it's the iron in the blood mixing with the oxygen that’s gives it the red color.

Keywords: Animation, Color, 3D, Advertising / Marketing, Editorial, Product Demonstration, Biology, Cell biology / Histology, Natural Science / Nature, Pharmacology, Vascular Surgery

© singlecell animation

Single Cell Animation, llc

medical illustration of As the main part of the Central Nervous System, the brain takes information from the Sensory Neurons (like the nerves in finger tips) and relays it to Motor Neurons (muscles). It’s our cerebral cortex that separates us from other mammals, giving us language, thought, memory, awareness, perception… medical illustration of As the main part of the Central Nervous System, the brain takes information from the Sensory Neurons (like the nerves in finger tips) and relays it to Motor Neurons (muscles). It’s our cerebral cortex that separates us from other mammals, giving us language, thought, memory, awareness, perception…

Brain

As the main part of the Central Nervous System, the brain takes information from the Sensory Neurons (like the nerves in finger tips) and relays it to Motor Neurons (muscles). It’s our cerebral cortex that separates us from other mammals, giving us language, thought, memory, awareness, perception…

Keywords: Animation, Color, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Anatomy, Neuroscience, Neurosurgery, Oncology

© singlecell animation

Single Cell Animation, llc

medical illustration of T cells are part of the immune system. They help by tagging pathogens and warn of an attack on the body. medical illustration of T cells are part of the immune system. They help by tagging pathogens and warn of an attack on the body.

Immune System

T cells are part of the immune system. They help by tagging pathogens and warn of an attack on the body.

Keywords: Animation, Color, Design, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Biotechnology, Cell biology / Histology, Disease Management

© singlecell animation

Single Cell Animation, llc

medical illustration of Sensory neurons for example, deal with touch and pain. They can be paired with a motor neurons, which get the muscles going… and the Interneurons pretty much act as a router between the different neurons. medical illustration of Sensory neurons for example, deal with touch and pain. They can be paired with a motor neurons, which get the muscles going… and the Interneurons pretty much act as a router between the different neurons.

Neurons

Sensory neurons for example, deal with touch and pain. They can be paired with a motor neurons, which get the muscles going… and the Interneurons pretty much act as a router between the different neurons.

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Biotechnology, Cell biology / Histology, Neuroscience, Neurosurgery

© singlecell animation

Single Cell Animation, llc

medical illustration of Red Blood cells live for around 120 days and are produced in the marrow of the bones. They contain Hemoglobin, a protein that stores the oxygen for the body to survive. medical illustration of Red Blood cells live for around 120 days and are produced in the marrow of the bones. They contain Hemoglobin, a protein that stores the oxygen for the body to survive.

Red Blood Cell

Red Blood cells live for around 120 days and are produced in the marrow of the bones. They contain Hemoglobin, a protein that stores the oxygen for the body to survive.

Keywords: Animation, Color, Design, 3D, Advertising / Marketing, Editorial, Multimedia, Patient Education, Biology, Cell biology / Histology

© singlecell animation

Single Cell Animation, llc

medical illustration of The cell surface is a membrane layer that protects the cell from the outside elements. medical illustration of The cell surface is a membrane layer that protects the cell from the outside elements.

cell surface

The cell surface is a membrane layer that protects the cell from the outside elements.

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Biotechnology, Cell biology / Histology, Molecular Biology, Oncology

© singlecell animation

Single Cell Animation, llc

medical illustration of The vertebrae interlock in a flexible way that protects the spinal cord while preserving the ability to bend and twist. The human spinal column is made up of 33 bones • 7 vertebrae in the cervical region, • 12 in the thoracic region, • 5 in the lumbar region, • 5 in the sacral region and • 4 in the coccygeal region medical illustration of The vertebrae interlock in a flexible way that protects the spinal cord while preserving the ability to bend and twist. The human spinal column is made up of 33 bones • 7 vertebrae in the cervical region, • 12 in the thoracic region, • 5 in the lumbar region, • 5 in the sacral region and • 4 in the coccygeal region

spinal column

The vertebrae interlock in a flexible way that protects the spinal cord while preserving the ability to bend and twist. The human spinal column is made up of 33 bones • 7 vertebrae in the cervical region, • 12 in the thoracic region, • 5 in the lumbar region, • 5 in the sacral region and • 4 in the coccygeal region

Keywords: Animation, Color, 3D, Live Action Video, Advertising / Marketing, Editorial, Education, Product Demonstration, Anatomy, Orthopaedics, Physical Therapy, Injuries

© singlecell animation

Single Cell Animation, llc

medical illustration of An ulcer can form in the small intestine and could be caused by your diet. They can lead to breaks in the lining of your stomach potentially leading to other problems. medical illustration of An ulcer can form in the small intestine and could be caused by your diet. They can lead to breaks in the lining of your stomach potentially leading to other problems.

Ulcer

An ulcer can form in the small intestine and could be caused by your diet. They can lead to breaks in the lining of your stomach potentially leading to other problems.

Keywords: Animation, 3D, Live Action Video, Advertising / Marketing, Editorial, Education, Product Demonstration, Professional Education, Anatomy, Biology, Cell biology / Histology, Disease Management, Gastroenterology

© singlecell animation

Single Cell Animation, llc

medical illustration of The basic function is to protect the cell from it's surroundings. medical illustration of The basic function is to protect the cell from it's surroundings.

Membrane Surface

The basic function is to protect the cell from it's surroundings.

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Cell biology / Histology, Molecular Biology, Natural Science / Nature

© singlecell animation

Single Cell Animation, llc

medical illustration of Bacteria come in many different shapes and sizes, but three basic shapes are spherical, rod and spiral. These are H. pylori and swim using flagella, propeller like appendages. After they enter your body, they settle comfortably in your Digestive Track. Over time they can cause ulcers in the lining of your stomach. Common ways this bacteria spreads is from are water and food, along with poor sewage systems medical illustration of Bacteria come in many different shapes and sizes, but three basic shapes are spherical, rod and spiral. These are H. pylori and swim using flagella, propeller like appendages. After they enter your body, they settle comfortably in your Digestive Track. Over time they can cause ulcers in the lining of your stomach. Common ways this bacteria spreads is from are water and food, along with poor sewage systems

Bacteria

Bacteria come in many different shapes and sizes, but three basic shapes are spherical, rod and spiral. These are H. pylori and swim using flagella, propeller like appendages. After they enter your body, they settle comfortably in your Digestive Track. Over time they can cause ulcers in the lining of your stomach. Common ways this bacteria spreads is from are water and food, along with poor sewage systems

Keywords: Animation, 3D, Live Action Video, Advertising / Marketing, Editorial, Education, Product Demonstration, Allergy / Immunology, Biology, Biotechnology, Disease Management, Gastroenterology, General Medicine, Pharmacology

© singlecell animation

Single Cell Animation, llc

medical illustration of A stem cell can essentially be programmed to become any cell in the body. This is a Single Cell out of trillions that make up the body, and each cell is made from many different parts called organelles. They’re like organs for the cell, and help convert nutrients from what you eat and drink into energy, and some cells divide to help replenish the older, unhealthier, dying cells medical illustration of A stem cell can essentially be programmed to become any cell in the body. This is a Single Cell out of trillions that make up the body, and each cell is made from many different parts called organelles. They’re like organs for the cell, and help convert nutrients from what you eat and drink into energy, and some cells divide to help replenish the older, unhealthier, dying cells

Stem Cell

A stem cell can essentially be programmed to become any cell in the body. This is a Single Cell out of trillions that make up the body, and each cell is made from many different parts called organelles. They’re like organs for the cell, and help convert nutrients from what you eat and drink into energy, and some cells divide to help replenish the older, unhealthier, dying cells

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Biotechnology, Cell biology / Histology, Molecular Biology

© singlecell animation

Single Cell Animation, llc

medical illustration of DNA carrying genetic information starts wrapping around protein molecules called histones found in the nucleus. They continue to coil around and around eventually forming chromosomes. It’s a process that combines mom and dad genes together. Without packaging, the DNA strands would be too long to fit inside cells medical illustration of DNA carrying genetic information starts wrapping around protein molecules called histones found in the nucleus. They continue to coil around and around eventually forming chromosomes. It’s a process that combines mom and dad genes together. Without packaging, the DNA strands would be too long to fit inside cells

DNA

DNA carrying genetic information starts wrapping around protein molecules called histones found in the nucleus. They continue to coil around and around eventually forming chromosomes. It’s a process that combines mom and dad genes together. Without packaging, the DNA strands would be too long to fit inside cells

Keywords: Animation, 3D, Advertising / Marketing, Editorial, Education, Product Demonstration, Biology, Genetics, Molecular Biology

© singlecell animation

Single Cell Animation, llc

medical illustration of The main function of the kidneys are to filter and remove waste products from the body. medical illustration of The main function of the kidneys are to filter and remove waste products from the body.

Kidney Cross Section

The main function of the kidneys are to filter and remove waste products from the body.

Keywords: Animation, 3D, Live Action Video, Advertising / Marketing, Editorial, Education, Product Demonstration, Anatomy

© singlecell animation

Single Cell Animation, llc

medical illustration of Showing plaque buildup within the Artery wall.
medical illustration of HIV - Human Immunodeficiency Virus destroys the T cells of the immune system, eventually leading to AIDS.
medical animation of An animation showing the moving parts of the Respiratory System. The Lungs are different from one another. The right consists of three lobes, Superior, Middle, and Inferior, while the left only has two, the Superior and Inferior.
medical animation of A time lapse of Melanoma growing over a 3 month period.
medical animation of An animation of an 8 week embryo inside the womb.
medical animation of It takes approximately 1 minute for the heart to circulate 4-5 quarts of blood around the body - back to the heart.
medical illustration of Prescription drugs are made to cure, treat, and prevent disease in many interesting ways. Most medicines today are artificially produced by scientific study and testing. Scientists can isolate all the useful chemicals from plants and animals and over time produce a drug targeted to a particular ailment.
medical illustration of Melanoma is a skin cancer developing within the melanocytes (pigment cells). This form of skin cancer may spread to other parts of the body (metastasize), potentially causing a serious illness or death. What is cancer? It’s a group of abnormal cells dividing uncontrollably, eventually becoming a tumor.
medical illustration of The human body is made up of 11 organ systems, each doing a specific job.
medical illustration of Some fun experimenting with metal textures and realistic lighting.
medical illustration of These are Kinesin (a motor protein), and we are watching them walk along tracks (Microtubule) inside the cell. Their job is to tug along sacks (vesicles) filled with materials to be excreted from the cell. In this case, they are simply walking all the cell’s waste to the membrane, where it’s discarded outside of the cell.
medical illustration of upon entering the egg, the outer shell seals up, the head of the sperm unites with the nucleus of the egg, and within days.. A single cell will multiply, and keep multiplying to eventually form an embryo.
medical illustration of A Macrophage is part of the immune system. They patrol around the body, entering affected areas, engulfing and destroying bacteria and other pathogens. They also act as a janitor, cleaning up dead cells and other debris around the body, keeping it clean and healthy.
medical illustration of This is a human embryo at approximately 8 weeks old inside a woman’s womb. The amniotic sac protects the growing baby while the organs and muscles are beginning to work.
medical illustration of red blood cells carry and deliver packages of oxygen to all the organs throughout the body. Red blood cells are made in the bone marrow and circulate the body for around 4 months before dying, and it's the iron in the blood mixing with the oxygen that’s gives it the red color.
medical illustration of As the main part of the Central Nervous System, the brain takes information from the Sensory Neurons (like the nerves in finger tips) and relays it to Motor Neurons (muscles). It’s our cerebral cortex that separates us from other mammals, giving us language, thought, memory, awareness, perception…
medical illustration of T cells are part of the immune system. They help by tagging pathogens and warn of an attack on the body.
medical illustration of Sensory neurons for example, deal with touch and pain. They can be paired with a motor neurons, which get the muscles going… and the Interneurons pretty much act as a router between the different neurons.
medical illustration of Red Blood cells live for around 120 days and are produced in the marrow of the bones. They contain Hemoglobin, a protein that stores the oxygen for the body to survive.
medical illustration of The cell surface is a membrane layer that protects the cell from the outside elements.
medical illustration of The vertebrae interlock in a flexible way that protects the spinal cord while preserving the ability to bend and twist. The human spinal column is made up of 33 bones • 7 vertebrae in the cervical region, • 12 in the thoracic region, • 5 in the lumbar region, • 5 in the sacral region and • 4 in the coccygeal region
medical illustration of An ulcer can form in the small intestine and could be caused by your diet. They can lead to breaks in the lining of your stomach potentially leading to other problems.
medical illustration of The basic function is to protect the cell from it's surroundings.
medical illustration of Bacteria come in many different shapes and sizes, but three basic shapes are spherical, rod and spiral. These are H. pylori and swim using flagella, propeller like appendages. After they enter your body, they settle comfortably in your Digestive Track. Over time they can cause ulcers in the lining of your stomach. Common ways this bacteria spreads is from are water and food, along with poor sewage systems
medical illustration of A stem cell can essentially be programmed to become any cell in the body. This is a Single Cell out of trillions that make up the body, and each cell is made from many different parts called organelles. They’re like organs for the cell, and help convert nutrients from what you eat and drink into energy, and some cells divide to help replenish the older, unhealthier, dying cells
medical illustration of DNA carrying genetic information starts wrapping around protein molecules called histones found in the nucleus. They continue to coil around and around eventually forming chromosomes. It’s a process that combines mom and dad genes together. Without packaging, the DNA strands would be too long to fit inside cells
medical illustration of The main function of the kidneys are to filter and remove waste products from the body.

Profile

Single Cell Animation provides 3D Animation & Illustration for the Medical & Scientific Industry - From MoA animations and Medical Device Marketing to Editorial and Education - Our clients include Pharmaceutical and Biotechnology Companies, Healthcare Agencies, Hospitals, and Universities - Always delivering a clear visual message for all audiences.

Style/Techniques

Animation, Color, Design, Caricature, 3D, Apps/Mobile, Models, Live Action Video

Subject/Specialties

Allergy / Immunology, Alternative Medicine, Anatomy, Biology, Biotechnology, Cell biology / Histology, Dermatology, Disease Management, Embryology, Emergency Medicine, Gastroenterology, General Medicine, General Surgery, Genetics, Maternal / Child, Medical Devices, Molecular Biology, Natural Science / Nature, Neuroscience, Neurosurgery, Orthopaedics, Pediatrics, Pharmacology, Physical Therapy, Reproductive Biology, Respiratory, Vascular Surgery, Injuries, Oncology, Mechanism of Action (MOA), Health & Wellness, Hemophilia