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Thrombopoeitin Receptor Agonist

Thrombopoietin (TPO) is a protein produced primarily in the liver that controls how many platelets are made. In people with chronic Idiopathic Thrombocytopenia (ITP) there usually isn't enough TPO (orange) reaching the bone marrow when platelet levels get low. TPO Receptor Agonist (green) works by stimulating megakaryocytes and their precursors in the bone marrow, leading to proliferation and differentiation of these cells.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Pharmacology, Mechanism of Action (MOA)

© Edmond Alexander

Bispecific Monoclonal Antibody

A bispecific monoclonal antibody is engineered to simultaneously bind to a cytotoxic cell and a targeted tumor cell.

Keywords: Airbrush, 3D, Advertising / Marketing, Allergy / Immunology, Biotechnology, Cell biology / Histology, Disease Management, Molecular Biology, Pharmacology, Mechanism of Action (MOA)

© Edmond Alexander

Activating Membrane Proteins

Unique cell proteins are distributed across the cell surface to accept communication signals from extracellular signaling ligands like hormones, neurotransmitters, cell recognition molecules and growth factors.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Pharmacology, Mechanism of Action (MOA)

© Edmond Alexander

Plasma Cell Membrane with CD38 Receptors

Protein-ligand binding activates the lipid membrane surface protein to trigger intracellular signaling pathways. CD38 is a surface protein for cell activation found on immune cells, and its deficiency is linked to impaired immune responses and metabolic disturbances.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Biotechnology, Disease Management, Molecular Biology, Pharmacology

© Edmond Alexander

Tumor Cell Membrane Destruction

Receptor Tyrosine Kinase (RTKs) are high-affinity cell surface receptors for cell maintenance but also initiate the development of many cancers. RTK occurs when a ligand attaches to the HER 2 receptor and then connects to the HER 3 receptor, signaling intracellular proteins to initiate cell division. Here, the ligand attaches to the HER 3 receptor but the anti-tumor drug (sphere at base of the receptor) prevents the joining of HER 3 and HER 2, resulting in membrane destruction and cell death.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Molecular Biology, Oncology, Mechanism of Action (MOA)

© Edmond Alexander

Your Move

The immune system is the human body’s amazing self defense system which fights off foreign invaders that threaten the health of the human body. Cancer is a formidable invader and an aggressive challenger. It can capture the human circulatory system to feed its survival and to transport its invasion to other areas of the body. It never plays by the rules. Your move.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Disease Management, Pharmacology

© Edmond Alexander

Cyberoid Brain

Concept art for proposed gaming project depicting cyberoid brain.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Games, Anatomy, Neuroscience

© Edmond Alexander

Alimta

Anticancer drug passes through the folate carrier of the tumor cells and prevents actions that promote cell division and angiogenesis.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Molecular Biology, Pharmacology, Oncology, Mechanism of Action (MOA)

© Edmond Alexander

Cell Mural

Wall mural and branding image for a rheumatologist’s private practice who wished to convey that rheumatology is not only about joints and the skeleton but also a specialty that deals with autoimmune diseases, systemic inflammatory conditions and the immune system for a holistic diagnostic approach to restore health.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Cell biology / Histology, Disease Management, Molecular Biology

© Edmond Alexander

VEGF and MET Receptors

Antitumor drugs target the intracellular component of the signaling protein receptors VEGF and MET to block tumor angiogenesis and metastasis.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Molecular Biology, Oncology, Mechanism of Action (MOA)

© Edmond Alexander

Myelin Sheaths of Neurons

Myelin is the electrically-insulating phospholipid sheath that surrounds the axons of many neurons and enables impulses to hop or “propagate by saltation.”

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Anatomy, Cell biology / Histology, Neuroscience

© Edmond Alexander

Myelin Sheaths and Nerve Impulses

Myelin is the electrically-insulating phospholipid sheath that surrounds the axons of many neurons and enables impulses to hop or “propagate by saltation.”

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Neuroscience

© Edmond Alexander

Blood Platelet Activation

Platelets are small, irregularly-shaped anuclear cells circulating in the blood to maintain hemostasis by forming blood clots when damage to the endothelium of blood vessels occurs.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Pharmacology

© Edmond Alexander

Blood Clot

Blood loss stimulates fibrinogen to convert fibrin strands which then trap platelets and blood cells, forming a mesh that creates a hemostatic plug over the wound site.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Pharmacology

© Edmond Alexander

Gene Therapy for Neurons

Exogenous migratory therapy techniques use stem cells to repair damaged neurons after traumatic injury or degenerative disease.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management

© Edmond Alexander

MS Blood Brain Barrier

Multiple sclerosis (MS) is a demyelinating disease that damages the insulating membranes of nerve cells and disrupts the ability of parts of the nervous system to communicate.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Disease Management

© Edmond Alexander

The Human Cell

The human cell contains numerous organelles that govern cell function, survival and reproduction.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology

© Edmond Alexander

Future Science Concept Art

Concept art for proposed interactive game depicting how man will be miniaturized and be placed into a bio-engineered “ribosome-like” vessel capable of exploring the inside of human cells. Interactive gamers explore the intracellular environment to detect the future DNA health of individual cell groups as well as diagnose and treat disease.

Keywords: Airbrush, Color, 3D, Games, Cell biology / Histology, Disease Management

© Edmond Alexander

Control Panel Concept Art

Concept art for proposed interactive game depicting how man will be miniaturized and be placed into a bio-engineered “ribosome-like” vessel capable of exploring the inside of human cells. Interactive gamers explore the intracellular environment to detect the future DNA health of individual cell groups as well as diagnose and treat disease.

Keywords: Airbrush, Color, 3D, Games, Cell biology / Histology, Disease Management

© Edmond Alexander

Future Health Predictions

Concept art for an interactive gaming where players explore the human body at the cellular level. The spherized DNA molecule allows players to monitor the health of the cells being investigated.

Keywords: Airbrush, Color, 3D, Games, Disease Management, Molecular Biology

© Edmond Alexander

Botulinum Toxin

Surface and ribbon representations of the Botulinum toxin protein produced by produced by the bacterium Clostridium botulinum.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Molecular Biology

© Edmond Alexander

T Cell and Macrophages

Macrophages present antigens of destroyed pathogens on their surfaces for T cells to retrieve and thereby initiate the immune response.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Cell biology / Histology

© Edmond Alexander

Cancer Cells

Cancer cells are abnormal cells that divide uncontrollably and destroy body tissue.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Oncology

© Edmond Alexander

Cell Division

Before successful cell division can occur the genomic information stored in chromosomes must be replicated, and the duplicated genome separated cleanly between cells.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology

© Edmond Alexander

Bacterial Replication

Unicellular organisms like bacteria grow to a fixed size and then reproduce through binary fission - a form of asexual reproduction.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology

© Edmond Alexander

White Blood Cells

White blood cells are diverse immune system cells that defend the body against both infectious disease and foreign materials.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology

© Edmond Alexander

Cytokine Activation of T Cells

Cytokines are signaling proteins and glycoproteins that are used extensively in cellular communication for both innate and adaptive immune responses.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Cell biology / Histology

© Edmond Alexander

Stem Cell Therapy

Exogenous migratory therapy techniques use stem cells to repair damaged neurons after traumatic injury or degenerative disease. For Stanford Department of Neurosurgery, Stanford University School of Medicine.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Disease Management, Neuroscience, Neurosurgery

© Edmond Alexander

Blocking Pathogen Reproduction

Because a virus is unable to reproduce outside a host cell, blocking the cell’s replication pathway will also block replication of the virus.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Cell biology / Histology, Virology

© Edmond Alexander

Dry Eye and Tear Layers Damage

Dry eye damages the three tear film layers (mucin, aqueous and lipid) of the normal ocular surface and causes hypertonic stress to the corneal epithelial cells.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Ophthalmology

© Edmond Alexander

Factor IX

Factor IX, or Christmas factor, is one of the serine proteases of the coagulation system. Deficiency of this protein causes Hemophilia B.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Pharmacology, Hemophilia

© Edmond Alexander

Cyberoid Circulatory System

Concept art for proposed gaming project depicting cyberoid circulatory system.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Games, Anatomy

© Edmond Alexander

LCA - Left Coronary Artery

The left coronary artery arises from the aorta above the left cusp of the aortic valve and feeds the left side of the heart.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Anatomy, Cardiac Surgery / Cardiology

© Edmond Alexander

Liver and Kidneys

Visualization of the anatomical relationship of the liver and kidneys to highlight a detoxification program.

Keywords: Airbrush, Color, 3D, Education, Anatomy, Gastroenterology

© Edmond Alexander

Chaos to Order

DNA microarray technology analyzes reproducible and aligned array patterns to bring order to large amounts of gene data.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Biotechnology, Genetics

© Edmond Alexander

Granulating Mast Cell

When activated, mast cells rapidly release histamine, heparin, and various hormonal mediators by degranulation to regulate allergy, anaphylaxis and wound healing.

Keywords: Airbrush, Color, Editorial, Allergy / Immunology, Disease Management

© Edmond Alexander

Immune Response Transfer

When macrophages destroy pathogens they place antigens on their surfaces to stimulate the immune system. T Cells then pick up the antigens and orchestrate the immune response.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Cell biology / Histology

© Edmond Alexander

Swine Flu Virus

Transmission of the swine flu virus from pigs to humans is not common and does not always lead to human influenza, often resulting only in the production of antibodies in the blood.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Virology

© Edmond Alexander

Monoclonal Antibody Attack

Monoclonal antibodies are “magic bullets” bioengineered to target specific cancer cells with a toxin delivered by its agent of selectivity.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Biotechnology, Pharmacology

© Edmond Alexander

Monoclonal Antibody Touchdown

Because monoclonal antibodies are monospecific antibodies that are made of identical immune cells that are all clones of a unique parent cell, monoclonal antibodies have monovalent affinity and bind to the same epitope.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Biotechnology, Pharmacology

© Edmond Alexander

Monoclonal Antibody Encapsulation by Cell Membrane

When a monoclonal antibody attaches to the surface of a targeted cell it is encapsulated and brought into the cell where it then initiates cell destruction.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Biotechnology, Cell biology / Histology, Pharmacology

© Edmond Alexander

Antitumor Pathways (CNTO 328)

Mapping of interventional pathways into the cell for antitumor therapy.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Pharmacology, Oncology

© Edmond Alexander

Intracellular Pathways

Numerous intracellular pathways of tumor cells are being explored as delivery routes for new drug therapies designed to interrupt tumor cell replication by preventing angiogenesis and cell division.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Biotechnology, Cell biology / Histology, Pharmacology, Oncology

© Edmond Alexander

Severe ADAMTS13 Deficiency

ADAMTS13 is an enzyme produced by the vascular endothelium that cleaves von Willebrand Factor, a protein that mediates platelet adhesion and aggregation at sites of vascular injury. Deficient levels of ADAMTS13 allows platelets to bind to uncleaved von Willebrand Factor multimers and leads to thrombotic microangiopathy.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Biotechnology, Disease Management, Pharmacology

© Edmond Alexander

Microbe Destruction

Destruction of virulent microbe strains is hampered by the microbe’s protective outer membrane. Stronger antimicrobial drugs are able to penetrate and destroy the outer membrane and expose the more vulnerable inner membrane.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Allergy / Immunology, Disease Management, Pharmacology, Virology

© Edmond Alexander

Moxifloxacin

Concept art depicting quinolone antibiotic attack on difficult-to-destroy pathogens.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Pharmacology

© Edmond Alexander

Inner Membrane Cell Destruction

After an antibiotic penetrates the tough exterior shell of a microbial cyst, the antibiotic “smart bomb” targets the inner membrane. For Alcon.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Ophthalmology, Pharmacology

© Edmond Alexander

Nelarabine MOA

Nelarabine MOA for treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. For GlaxoSmithKline.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Pharmacology, Oncology

© Edmond Alexander

Neuropathic Pain

Normal, hyperactive, suppressed and recovering nerves. For Giant Creative.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Cell biology / Histology, Neuroscience

© Edmond Alexander

Hepatocyte Stress

Pulmonary hypertension drug therapy regimes can have negative affects on hepatocytes in the liver due to the build-up of bile salts. For Volibris® for GlaxoSmithKline.

Keywords: Airbrush, Color, 3D, Advertising / Marketing, Disease Management, Pharmacology, Respiratory

© Edmond Alexander

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Edmond Alexander

Represented by

Shannon Associates
333 West 57th Street, Suite 809
New York, NY 10019
United States

Biography

Edmond is a certified medical illustrator and a Fellow of the Association of Medical Illustrators. He received a Bachelor of Science, in Pre Biological Oceanography and Art at the University of Southern Mississippi 1967. Edmond began his career in medical illustration at the University of Texas Medical Schools in Galveston and then in Dallas where he created medical illustration for print and motion media. While in Dallas he also taught for seven years at the Graduate Program in Biomedical Illustration at the University of Texas Southwestern Medical School. He specializes in the 2D and 3D visualizations of cellular and molecular subjects, pathophysiology, and drug modes-of-actions for pharmaceutical companies, their agencies, and medical publishers. His illustration was heavily influenced by the beauty of the Disney films during his childhood years, and the art of Frank Armitage during his formative years in medical illustration. He is known for his rich sense of color and his uniquely memorable visual solutions to complex subjects. Edmond is the recipient of numerous national and international awards for his illustrations, his work in motion media and natural science photography including the Association of Medical Illustrators, Texas Scientific Communicators, Biological Photographic Association, Health Science Communication Association, New York International Film and Television Festival, Houston International Film Festival, SeaSpace International Underwater Photography Exhibition, and Fort Worth and Austin Addy Awards. Edmond’s work was selected to exhibit in the juried Art of Medicine Exhibition, New York; featured in The Best in Medical Advertising, Rockport Publishers; featured in The Guild Handbook of Scientific Illustration, Van Nostrand Reinhold; and showcased in Kai’s Power Tools and Studio Secrets, IDG Books Worldwide.

Style/Techniques

Airbrush, Color, 3D

Subject/Specialties

Allergy / Immunology, Anatomy, Biotechnology, Cardiac Surgery / Cardiology, Cell biology / Histology, Disease Management, Gastroenterology, Genetics, Molecular Biology, Neuroscience, Neurosurgery, Ophthalmology, Pharmacology, Respiratory, Virology, Oncology, Mechanism of Action (MOA), Hemophilia