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Woodhead Publishing Series in Biomedicine

Therapeutic Antibody Engineering

Next Image Title

Artist Name

W.R. Strohl and L.M. Strohl, 2012
medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli

Macrophages Attacking S. pneumoniae

Macrophages attacking S. pneumoniae in pulmonary alveoli

Keywords: Airbrush, Color, Stock, Allergy / Immunology, Cell biology / Histology, Molecular Biology

© Lila Strohl
medical illustration of IgG Antibody medical illustration of IgG Antibody

IgG Antibody

IgG Antibody

Keywords: Airbrush, Information Graphics, Publishing, Technology, Web, Research, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)

© Lila Strohl
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Innate Immunity MOA for Anti-CD47 Antibodies

Proposed innate immunity mechanism of action for anti-CD47 antibodies. Blocking the CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Keywords: Airbrush, Color, Publishing, Web, Professional Education, Research, Biotechnology, Molecular Biology, Oncology, Mechanism of Action (MOA)

medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized). 
medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Blocking CD47/SIRP-a Interaction

SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal). Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Keywords: Airbrush, Color, Publishing, Web, Professional Education, Research, Biotechnology, Molecular Biology, Oncology, Mechanism of Action (MOA)

medical illustration of Antibody Art medical illustration of Antibody Art

Antibody

Antibody Art

Keywords: Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology

© Lila Strohl
medical illustration of Antibodies binding to receptors on the surface of a B cell medical illustration of Antibodies binding to receptors on the surface of a B cell

Antibodies

Antibodies binding to receptors on the surface of a B cell

Keywords: Allergy / Immunology, Biology, Biotechnology, Cell biology / Histology, Molecular Biology

© Lila Strohl
medical illustration of Anti-CD20 antibodies binding CD20,an integral membrane protein on the surface of B cells medical illustration of Anti-CD20 antibodies binding CD20,an integral membrane protein on the surface of B cells

Anti-CD20 Antibodies

Anti-CD20 antibodies binding CD20,an integral membrane protein on the surface of B cells

Keywords: Stock, Biotechnology, Cell biology / Histology, Molecular Biology

© Lila Strohl

AMI #28

Page 153

AMI #27

Page 66

AMI #26

Page 147

medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli
medical illustration of IgG Antibody
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.
medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).
medical illustration of Antibody Art
medical illustration of Antibodies binding to receptors on the surface of a B cell
medical illustration of Anti-CD20 antibodies binding CD20,an integral membrane protein on the surface of B cells

Style/Techniques

Airbrush, Color, Information Graphics

Subject/Specialties

Allergy / Immunology, Biology, Biotechnology, Cell biology / Histology, Molecular Biology, Oncology, Mechanism of Action (MOA)