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Woodhead Publishing Series in Biomedicine

Therapeutic Antibody Engineering

Next Image Title

Artist Name

W.R. Strohl and L.M. Strohl, 2012
medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli

Macrophages Attacking S. pneumoniae

Macrophages attacking S. pneumoniae in pulmonary alveoli

Keywords: Airbrush, Color, Advertising / Marketing, Web, Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology, Pharmacology, Mechanism of Action (MOA)

© Lila Strohl
medical illustration of IgG Antibody medical illustration of IgG Antibody

IgG Antibody

IgG Antibody

Keywords: Airbrush, Color, Publishing, Web, Research, Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)

© Lila Strohl
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Innate Immunity MOA for Anti-CD47 Antibodies

Proposed innate immunity mechanism of action for anti-CD47 antibodies. Blocking the CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Molecular Biology, Oncology, Mechanism of Action (MOA)

medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized). 
medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Blocking CD47/SIRP-a Interaction

SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal). Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)

medical illustration of Antibody Art medical illustration of Antibody Art

Antibody

Antibody Art

Keywords: Airbrush, Color, Advertising / Marketing, Editorial, Web, Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)

© Lila Strohl
medical illustration of Artistic representation of antibodies coming in for a landing and binding to receptors on the surface of a B cell
medical illustration of Artistic representation of antibodies coming in for a landing and binding to receptors on the surface of a B cell

Artful Antibodies

Artistic representation of antibodies coming in for a landing and binding to receptors on the surface of a B cell

Keywords: Allergy / Immunology, Biology, Biotechnology, Cell biology / Histology, Genetics, Molecular Biology, Pharmacology, Oncology, Mechanism of Action (MOA), Pathology

© Lila Strohl
medical illustration of Anti-CD20 antibodies binding to the N-terminal portion of CD20, i.e., the smaller extracellular loop and a few residues on the larger extracellular loop, versus the binding of an anti-CD20 antibody to CD20 towards the C-terminal portion of the larger loop. medical illustration of Anti-CD20 antibodies binding to the N-terminal portion of CD20, i.e., the smaller extracellular loop and a few residues on the larger extracellular loop, versus the binding of an anti-CD20 antibody to CD20 towards the C-terminal portion of the larger loop.

Anti-CD20 Antibodies Binding CD20

Anti-CD20 antibodies binding to the N-terminal portion of CD20, i.e., the smaller extracellular loop and a few residues on the larger extracellular loop, versus the binding of an anti-CD20 antibody to CD20 towards the C-terminal portion of the larger loop.

Keywords: Airbrush, Color, Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology, Pharmacology, Oncology, Mechanism of Action (MOA), Pathology

© Lila Strohl

AMI #28

Page 153

AMI #27

Page 66

AMI #26

Page 147

medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli
medical illustration of IgG Antibody
medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.
medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).
medical illustration of Antibody Art
medical illustration of Artistic representation of antibodies coming in for a landing and binding to receptors on the surface of a B cell
medical illustration of Anti-CD20 antibodies binding to the N-terminal portion of CD20, i.e., the smaller extracellular loop and a few residues on the larger extracellular loop, versus the binding of an anti-CD20 antibody to CD20 towards the C-terminal portion of the larger loop.

Biography

Lila Strohl is a board Certified Medical Illustrator and a member of the Association of Medical Illustrators since 1993. Lila received a Bachelor of Science in Allied Health Professions in 1978 from The Ohio State University, The School of Allied Medical Professions-The College of Medicine. Her past experience includes work as Head of Medical Illustration at St. Anthony Medical Center, Columbus, Ohio (1978-1986), work as a staff Medical Illustrator in the department of Biomedical Communications at The Ohio State University (1987-1988), and owner of Medcom Graphics, a sole proprietorship that specialized in medical-legal work in Columbus, Ohio (1989-1997) and medical and scientific illustration in Bridgewater, New Jersey (1998-2008). Lila's work experience is diverse and includes working with surgeons, scientists, law firms, universities, publishers and biotech companies. Lila is currently the owner of Biomedscapes (2008-present), a medical and scientific art company in Bridgewater, New Jersey. Biomedscapes specializes in the creation of scientific and medical illustrations depicting cellular and molecular landscapes and information graphics for immunology, cell and molecular biology, biotechnology, pharmacology and medicine.

Style/Techniques

Airbrush, Color, Information Graphics

Subject/Specialties

Allergy / Immunology, Biology, Biotechnology, Cell biology / Histology, Genetics, Molecular Biology, Pharmacology, Oncology, Mechanism of Action (MOA), Pathology