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Improving Resolution by Cryo-EM: ß-galactosidase 

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A Spitting Image in 3D

medical illustration of This molecule, beta-galactosidase, has been studied by the structural biology technique cryo-electron microscopy (cryoEM) in order to determine its structure. As cryo-EM technology has improved, the resolution of the resulting structures has improved from rough, low resolution maps (blue, left) to high resolution maps that enable model fitting (gold, right).

Cryo-electron microscopy received the 2017 Nobel Prize in Chemistry.
Next medical illustration of This illustration highlights 3 cryo-electron microscopy (cryo-EM) structures of a gated ion channel in the brain in 3 conformations (left - resting, middle - active, right - desensitized).

Ionotropic glutamate receptors (iGluRs) mediate intercellular signaling in the nervous system. Their pore domain crosses the neuron's cell membrane, and when activated, they allow ions to flow across the membrane.

Glutamate Receptor Gating Cycle

This molecule, beta-galactosidase, has been studied by the structural biology technique cryo-electron microscopy (cryoEM) in order to determine its structure. As cryo-EM technology has improved, the resolution of the resulting structures has improved from rough, low resolution maps (blue, left) to high resolution maps that enable model fitting (gold, right). Cryo-electron microscopy received the 2017 Nobel Prize in Chemistry.

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