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Receptor Tyrosine Kinase Flt-1 binds ligand PlGF  

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Glycosylated Membrane Protein

medical illustration of Under normal conditions, receptor tyrosine kinase Flt-1 (teal) binds to the ligand PlGF (orange). However, in preeclampsia, soluble Flt-1 (sFlt-1, dark teal) binds PlGF and prevents it from reaching Flt-1.

These images use color and composition to highlight the difference between both conditions. 

Keywords: Lipid bilayer, cell membrane, membrane protein, growth factor, cell signalling, MoA, dimer, RTK, cell surface
Next medical animation of Video overview of cryo-EM technique, from purified protein solution to 3D structure. Cryo-electron microscopy (cryo-EM) is an emerging structural biology method that recently achieved atomic resolution. This resolution is on par with the more traditional technique of X-ray crystallography. Cryo-EM now makes it possible to study a wider range of 3D molecular structures at high resolution.
This video version was created in collaboration with Science Magazine (narration, content cut direction)

Cryo-Electron Microscopy: Technique Overview

Under normal conditions, receptor tyrosine kinase Flt-1 (teal) binds to the ligand PlGF (orange). However, in preeclampsia, soluble Flt-1 (sFlt-1, dark teal) binds PlGF and prevents it from reaching Flt-1. These images use color and composition to highlight the difference between both conditions. Keywords: Lipid bilayer, cell membrane, membrane protein, growth factor, cell signalling, MoA, dimer, RTK, cell surface

Keywords: 3D, Advertising / Marketing, Editorial, Biology, Cell biology / Histology, Maternal / Child, Molecular Biology, Pharmacology, Mechanism of Action (MOA), Pathology

© Veronica Falconieri