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Falconieri Visuals

CRISPR-Cas Complex Protects Bacteria from Phages 

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G Protein Coupled Receptor in Membrane

medical illustration of Cover image accompanying article on CRISPR complex (Csy) from bacteria in complex with DNA and inhibitors. The molecule binds to invading bacteriophage (virus) DNA (orange) and splits the double helix open, preparing it for degradation by Cas proteins. Bacteria that deploy this immune system successfully can fend off viral invaders.

Guo et al. Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex. Cell. 2017 Oct 5;171(2):414-426.e12.
Next medical illustration of The magnesium ion channel CorA shifts between open and closed states depending on the concentration of magnesium ions inside of prokaryotic cells. Surprisingly, it abandons its symmetric closed shape for an asymmetric shape upon opening. 

In this cover image concept, CorA is seen in the open conformation. The stars represent the magnesium ions – since there are more outside of the membrane and few within, CorA opens.

This visual was created with Maxon Cinema4D, ePMV, and Adobe Photoshop.

Ion Channel CorA

Cover image accompanying article on CRISPR complex (Csy) from bacteria in complex with DNA and inhibitors. The molecule binds to invading bacteriophage (virus) DNA (orange) and splits the double helix open, preparing it for degradation by Cas proteins. Bacteria that deploy this immune system successfully can fend off viral invaders. Guo et al. Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex. Cell. 2017 Oct 5;171(2):414-426.e12.

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