Cover image accompanying article on CRISPR complex (Csy) from bacteria in complex with DNA and inhibitors. The molecule binds to invading bacteriophage (virus) DNA (orange) and splits the double helix open, preparing it for degradation by Cas proteins. Bacteria that deploy this immune system successfully can fend off viral invaders.
Guo et al. Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex. Cell. 2017 Oct 5;171(2):414-426.e12.
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