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Serous Salivary Acinus Structure

medical illustration of Subject:  Nanoscopic 3D data of mouse salivary cells, salivary acinus anatomy
Objective: Highlight the capabilities of focused ion beam scanning electron microscopy (FIB-SEM) in studying nanoscale biological features, using the example of a mouse salivary gland. These capabilities include not only 3D structural data, but many individual 2D images that capture multiple instances of a process, as demonstrated by the inset of the 3 stages of salivary vesicle fusion.
Next medical illustration of This molecule, beta-galactosidase, has been studied by the structural biology technique cryo-electron microscopy (cryoEM) in order to determine its structure. As cryo-EM technology has improved, the resolution of the resulting structures has improved from rough, low resolution maps (blue, left) to high resolution maps that enable model fitting (gold, right).

Cryo-electron microscopy received the 2017 Nobel Prize in Chemistry.

Improving Resolution by Cryo-EM: ß-galactosidase

Subject: Nanoscopic 3D data of mouse salivary cells, salivary acinus anatomy Objective: Highlight the capabilities of focused ion beam scanning electron microscopy (FIB-SEM) in studying nanoscale biological features, using the example of a mouse salivary gland. These capabilities include not only 3D structural data, but many individual 2D images that capture multiple instances of a process, as demonstrated by the inset of the 3 stages of salivary vesicle fusion.

Keywords: 3D, Education, Technology, Professional Education, Research, Biology, Biotechnology, Cell biology / Histology, Molecular Biology, Natural Science / Nature