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Falconieri Visuals

Structure of CRISPR-Cas Surveillance Complex 

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CENPA Nucleosome in Kinetochore Formation

medical illustration of Journal figure accompanying article on the structure of a CRISPR complex (Csy) from bacteria in complex with target DNA and inhibitors. Shows overal 3D subunit structure of CRISPR complex when bound to DNA.

Guo et al.
Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex.
Cell. 2017 Oct 5;171(2):414-426.e12. doi: 10.1016/j.cell.2017.09.006
Next medical illustration of Image of cryo-electron microscopy (cryo-EM) density map of protein p97 (purple, blue, and green). p97 is a target for cancer drugs in clinical trials, since its inhibition may prevent cancer cells from adequately disposing of excess protein through proteasome degradation. Research on this molecule informed ongoing oncology research and pharmaceutical development.

Cancer Drug Target p97

Journal figure accompanying article on the structure of a CRISPR complex (Csy) from bacteria in complex with target DNA and inhibitors. Shows overal 3D subunit structure of CRISPR complex when bound to DNA. Guo et al. Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex. Cell. 2017 Oct 5;171(2):414-426.e12. doi: 10.1016/j.cell.2017.09.006

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