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CENPA Nucleosome in Kinetochore Formation 

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Ebola in 3D

medical illustration of This journal figure illustrates how the CENP-A nucleosome complex with CENP-N (
Next medical illustration of Journal figure accompanying article on the structure of a CRISPR complex (Csy) from bacteria in complex with target DNA and inhibitors. Shows overal 3D subunit structure of CRISPR complex when bound to DNA. Guo et al. Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex. Cell. 2017 Oct 5;171(2):414-426.e12. doi: 10.1016/j.cell.2017.09.006

Structure of CRISPR-Cas Surveillance Complex

This journal figure illustrates how the CENP-A nucleosome complex with CENP-N ("A" structures connected to orange shapes) organizes nucleosomes (and thus DNA). This molecular complex is required for kinetochore formation and proper chromosome separation during cell division (mitosis)

Keywords: 3D, Models, Publishing, Research, Biology, Cell biology / Histology, Genetics, Molecular Biology, Oncology, Mechanism of Action (MOA)