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Limbic Pain 

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Vulvovaginal Graft vs Host Disease

medical illustration of Development of chronic pain and intractable cancer pain appears to be related to the activation of the NMDA receptors in certain areas of the central nervous system, especially the limbic system.
Next medical illustration of Kidney with overlay of nephrons showing methotrexate build-up in the collecting tubules.

Methotrexate Toxicity in the Kidney

Development of chronic pain and intractable cancer pain appears to be related to the activation of the NMDA receptors in certain areas of the central nervous system, especially the limbic system.

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