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SIRP?alphaFc Binding to Fcgamma?R and CD47 

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Glass Cell Highlighting Lysosomes

medical illustration of This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.
Next medical illustration of This diptych was created for a biotechnology firm. The first image shows the phagocytosis and digestion of a tumor cell. The second shows the further degradation of tumor cell fragments into short peptide strands by a proteasome, followed by the processing and presentation of tumor antigen to a T cell.

Diptych Showing Immune Response to a Tumor Cell

This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.

Keywords: Color, 3D, Models, Advertising / Marketing, Allergy / Immunology, Biotechnology, Cell biology / Histology, Molecular Biology, Pharmacology, Mechanism of Action (MOA)

© Audra Geras