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SIRP?alphaFc Binding to Fcgamma?R and CD47 

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The Pilar Apparatus

medical illustration of This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.
Next medical illustration of This conceptual illustration dramatically depicts a double-stranded DNA break. The client's drug functions to prevent DNA repair by PARP.

DNA Shatter

This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.

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© Audra Geras