On the left, the figure illustrates the pathways in which ubiquitination/deubiquitination leads to recycling of the CFTR membrane protein or its lysosomal degradation. On the right bacterially-produced Cif enters the cell and inhibits the USP10 activity, leading to increased degradation of CFTR and less of the protein in the membrane. For educational use as a slide or in print.
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© William Scavone