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Ubiquitination and CFTR Trafficking 

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Normal/Abnormal Termination of p53 Response

medical illustration of On the left, the figure illustrates the pathways in which ubiquitination/deubiquitination leads to recycling of the CFTR membrane protein or its lysosomal degradation. On the right bacterially-produced Cif enters the cell and inhibits the USP10 activity, leading to increased degradation of CFTR and less of the protein in the membrane. For educational use as a slide or in print.
Next medical illustration of Illustrates the ubiquitination/deubiquitination of TAP1, which is integral to the presentation of a viral peptide to an MHC Class 1 molecule in the endoplasmic reticulum, so that the antigen can be expressed on the cell membrane. Pseudomonas eruginosa infection releases Cif into the cell, inhibiting TAP1 deubiquitination which is increasingly degraded, interfering with antigen presentation.

Ubiquitination and TAP1 Trafficking

On the left, the figure illustrates the pathways in which ubiquitination/deubiquitination leads to recycling of the CFTR membrane protein or its lysosomal degradation. On the right bacterially-produced Cif enters the cell and inhibits the USP10 activity, leading to increased degradation of CFTR and less of the protein in the membrane. For educational use as a slide or in print.

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© William Scavone