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Jane Whitney

DNA vaccine MOA 

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SARS-CoV-2

medical illustration of Antigen-Presenting-Cells process antigens and present them to T-cells. The internalized antigen is digested into smaller peptides, which are then presented to T cells by the MHC. The antigen, here a SAR-CoV-2 spike, can be 1. phagocytosed by the cell, or 2. the DNA encoding the spike can be brought into the cell where the spike protein is made then digested.
Next medical illustration of This Covid-19 vaccine contains mRNA encoding for the spike protein of the virus, inside a liponanoparticle which mimics low-density lipoproteins, and allows them to be taken up by the cells. Once in the cytoplasm, the spike protein is manufactured through normal cell mechanisms and an antigen is presented on the cell surface for the immune system to recognize and mount a response.

Moderna mRNA-1273 SARS-CoV-2 vaccine

Antigen-Presenting-Cells process antigens and present them to T-cells. The internalized antigen is digested into smaller peptides, which are then presented to T cells by the MHC. The antigen, here a SAR-CoV-2 spike, can be 1. phagocytosed by the cell, or 2. the DNA encoding the spike can be brought into the cell where the spike protein is made then digested.

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