Thrombopoietin (TPO) is a protein produced primarily in the liver that controls how many platelets are made. In people with chronic Idiopathic Thrombocytopenia (ITP) there usually isn't enough TPO (orange) reaching the bone marrow when platelet levels get low. TPO Receptor Agonist (green) works by stimulating megakaryocytes and their precursors in the bone marrow, leading to proliferation and differentiation of these cells.
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© Edmond Alexander