SerbinCommunications

(805) 963-0439 | Toll-Free (800) 876-6425

www.serbin.com LA / NY / UK

Innate Immunity MOA for Anti-CD47 Antibodies 

Prev Next
Previous

Blocking CD47/SIRP-a Interaction

medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies.  Blocking the 
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to  T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.
Next medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli

Macrophages Attacking S. pneumoniae

Proposed innate immunity mechanism of action for anti-CD47 antibodies. Blocking the CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Molecular Biology, Oncology, Mechanism of Action (MOA)