SerbinCommunications

(805) 963-0439 | Toll-Free (800) 876-6425

www.serbin.com LA / NY / UK

Blocking CD47/SIRP-a Interaction 

Prev Next
Previous

Innate Immunity MOA for Anti-CD47 Antibodies

medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).
Next medical illustration of Antibody Art

Antibody

SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal). Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)