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Tim Fitzgerald

Chlorpyrifos 

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X-ray interpretation of Dog

medical illustration of This image, sized for a science journal, shows one effect of chlorpyrifos on the human body, particularly in the nervous system. In the ‘normal’ scenario, the enzyme acetylcholinesterase (or cholinesterase) breaks down the neurotransmitter, acetylcholine. In the clinical scenario, the pesticide inhibits the enzyme from working properly, thus leading to an accumulation of acetylcholine. The build-up can cause over-stimulation of nerves, muscles, and glands.
Next medical illustration of This image generalizes the electrochemical steps involved in memory depotentiation at the synapse between neurons. A stimulus activates NMDAR, which then permit calcium entry into the cell. As the cell depolarizes, VGCC activates and allows more calcium to flow into the cell. This intracellular calcium-oscillation mobilizes proteins that will eventually cause the cell to degrade the AMPA receptors by means of endocytosis.

Memory Depotentiation at the Synapse

This image, sized for a science journal, shows one effect of chlorpyrifos on the human body, particularly in the nervous system. In the ‘normal’ scenario, the enzyme acetylcholinesterase (or cholinesterase) breaks down the neurotransmitter, acetylcholine. In the clinical scenario, the pesticide inhibits the enzyme from working properly, thus leading to an accumulation of acetylcholine. The build-up can cause over-stimulation of nerves, muscles, and glands.

Keywords: Color, Information Graphics, Editorial, Patient Education, Professional Education, Research, Cell biology / Histology, Molecular Biology, Neuroscience, Pathology

© Tim Fitzgerald