This image generalizes the electrochemical steps involved in memory depotentiation at the synapse between neurons. A stimulus activates NMDAR, which then permit calcium entry into the cell. As the cell depolarizes, VGCC activates and allows more calcium to flow into the cell. This intracellular calcium-oscillation mobilizes proteins that will eventually cause the cell to degrade the AMPA receptors by means of endocytosis.
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© Tim Fitzgerald