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Tim Fitzgerald

Memory Depotentiation at the Synapse 

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Tat Injection and Effect Infographic

medical illustration of This image generalizes the electrochemical steps involved in memory depotentiation at the synapse between neurons. A stimulus activates NMDAR, which then permit calcium entry into the cell. As the cell depolarizes, VGCC activates and allows more calcium to flow into the cell. This intracellular calcium-oscillation mobilizes proteins that will eventually cause the cell to degrade the AMPA receptors by means of endocytosis.
Next medical illustration of This diagram shows the blood and nerve innervation of whale skin. The main area of focus is the dermal papilla, where the vessels from the dermis push the stratum basale up into the stratum granuloseum layer. The series of images along the bottom of the page demonstrate common patterns of innervation in the dermal papilla.

Whale Skin Innervation

This image generalizes the electrochemical steps involved in memory depotentiation at the synapse between neurons. A stimulus activates NMDAR, which then permit calcium entry into the cell. As the cell depolarizes, VGCC activates and allows more calcium to flow into the cell. This intracellular calcium-oscillation mobilizes proteins that will eventually cause the cell to degrade the AMPA receptors by means of endocytosis.

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© Tim Fitzgerald