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NLRP3 Inflammasome Assembly 

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medical illustration of This image highlights the core research of Harvard's Wu lab. The lab studies the structural biology of inflammasomes, signaling proteins key to the innate immune response, and wanted to have an image that highlighted both the NLRP3 inflammasome structures that they have determined (as of early 2021) and some of the related biology. The subunits of NLRP3 are shown assembling from inactive monomers (left) to the active, 11-fold symmetric signaling disk (right).
Next medical illustration of Science Translational Medicine cover, January 26, 2022. This illustration highlights research on a broadly neutralizing antibody against coronaviruses by the Baric Lab of UNC. Martinez, D. R. et al. A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. Sci. Transl. Med. 14, (2022).

Antibody to neutralize diverse coronaviruses

This image highlights the core research of Harvard's Wu lab. The lab studies the structural biology of inflammasomes, signaling proteins key to the innate immune response, and wanted to have an image that highlighted both the NLRP3 inflammasome structures that they have determined (as of early 2021) and some of the related biology. The subunits of NLRP3 are shown assembling from inactive monomers (left) to the active, 11-fold symmetric signaling disk (right).

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