(GLP-1) is derived from the transcription product of the proglucagon gene.It is a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion.GLP-1 appears to restore the glucose sensitivity of pancreatic β-cells.GLP-1 is also known to inhibit pancreatic β-cell apoptosis and stimulate the proliferation and differentiation of insulin-secreting β-cells. In addition, GLP-1 inhibits gastric secretion and motility.
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