During a stroke, the brain is starved of oxygen, triggering a chain reaction that causes water to flood brain cells. This happens through Aquaporin-4 (AQP4) channels, found on astrocyte cells lining the brain's protective barrier. Left unchecked, the buildup of fluid increases pressure inside the skull and can cause permanent brain damage. This illustration was created for an investigational IV drug that aims to block these AQP4 channels and prevent dangerous brain swelling.
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© Lisa A. Clark
