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Nature / Alessandro Vannini Lab

RNA Pol III

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RNA Polymerase III is responsible for making the short RNAs that are used for protein synthesis. When the structure of RNA Pol III was recently published in Nature, we were asked to provide the cover-art. See more here: https://www.nature.com/nature/journal/v553/n7688/index.html

Alessandro Vannini Lab

Phospho Biomedical Animation

medical illustration of Sequencing the DNA from tissue biopsies can be a valuable diagnostic tool, but not every way of preserving tissue is compatible with getting high-quality DNA for sequencing. In our animation for Genomics England we're discussing some of the issues with fixing tissue in formalin, and how frozen tissue can help get higher quality DNA samples for accurate sequencing. 

https://youtu.be/mHLY1PiK1cA
medical illustration of Sequencing the DNA from tissue biopsies can be a valuable diagnostic tool, but not every way of preserving tissue is compatible with getting high-quality DNA for sequencing. In our animation for Genomics England we're discussing some of the issues with fixing tissue in formalin, and how frozen tissue can help get higher quality DNA samples for accurate sequencing. 

https://youtu.be/mHLY1PiK1cA
medical illustration of Sequencing the DNA from tissue biopsies can be a valuable diagnostic tool, but not every way of preserving tissue is compatible with getting high-quality DNA for sequencing. In our animation for Genomics England we're discussing some of the issues with fixing tissue in formalin, and how frozen tissue can help get higher quality DNA samples for accurate sequencing. 

https://youtu.be/mHLY1PiK1cA
medical illustration of The receptor tyrosine kinase HER2 is overexpressed in around 20% of breast cancers. Here we show HER2 dimerisation with HER3 in ligand-induced as well as drug-induced orientations. 

For more information, read the full paper here:
https://elifesciences.org/articles/32271
medical illustration of Engineered T-cells are able to cross the blood brain barrier and home in on brain cancer. 

https://www.nature.com/nature/volumes/561/issues/7723
medical illustration of Antibody-drug-conjugates combine the sophistication of therapeutic antibodies with the power of chemotherapy drugs. ADC Bio makes manufacturing ADCs more accurate and less wasteful. 

For more information visit http://adcbio.com/
medical illustration of Antibody-drug-conjugates combine the sophistication of therapeutic antibodies with the power of chemotherapy drugs. ADC Bio makes manufacturing ADCs more accurate and less wasteful. 

For more information visit http://adcbio.com/
medical illustration of Exosomes are a highly effective way for cells to communicate with one another, allowing for delivery of sophisticated payloads from one cell to the next. 

For more information visit http://evoxtherapeutics.com/
medical illustration of Exosomes are a highly effective way for cells to communicate with one another, allowing for delivery of sophisticated payloads from one cell to the next. 
They're now being developed as a drug delivery platform by Evox Therapeutics. Because exosomes can travel across tissue barriers (like the blood brain barrier), they're able to deliver drugs to difficult-to-reach places in the body.

Watch the full animation at: https://youtu.be/9UMOV3tvFuk
medical illustration of Exosomes are a highly effective way for cells to communicate with one another, allowing for delivery of sophisticated payloads from one cell to the next. 
They're now being developed as a drug delivery platform by Evox Therapeutics. Because exosomes can travel across tissue barriers (like the blood brain barrier), they're able to deliver drugs to difficult-to-reach places in the body. 

Watch the full animation at: https://youtu.be/9UMOV3tvFuk
medical illustration of Exosomes are a highly effective way for cells to communicate with one another, allowing for delivery of sophisticated payloads from one cell to the next. 
They're now being developed as a drug delivery platform by Evox Therapeutics. Because exosomes can travel across tissue barriers (like the blood brain barrier), they're able to deliver drugs to difficult-to-reach places in the body. 

Watch the full animation at: https://youtu.be/9UMOV3tvFuk
medical illustration of Histones help pack the enormous amount of material in our genome. They are the protein complexes that DNA is wrapped around to reduce tangling and compress space. 

Here you see the wrapping of around 1 million basepairs of DNA, approximately 0.03% of the human genome.
medical illustration of RNA Polymerase III is responsible for making the short RNAs that are used for protein synthesis. When the structure of RNA Pol III was recently published in Nature, we were asked to provide the cover-art.

See more here: https://www.nature.com/nature/journal/v553/n7688/index.html
medical illustration of The coat of a virus-like particle is made up of a large number of repeating coat proteins. These can make for very effective vaccines, but packing them neatly with antigens is difficult and often doesn't allow for full coverage (shown here).
SpyBiotech's SpyTag / SpyCatcher technology allows the full coat to be packed fully with antigen, creating a huge amount of antigen presentation for the vaccine.

For more information, visit http://spybiotech.com/
medical illustration of The coat of a virus-like particle is made up of a large number of repeating coat proteins. These can make for very effective vaccines, but packing them neatly with antigens is difficult and often doesn't allow for full coverage.
SpyBiotech's SpyTag / SpyCatcher technology allows the full coat to be packed fully with antigen (shown here), creating a huge amount of antigen presentation for the vaccine.

For more information, visit http://spybiotech.com/
medical illustration of CRUK scientists at UCL and the Francis Crick Institute have redefined kidney cancer into a total of seven different subtypes based on their genetic fingerprint. These seven different subtypes have a well defined genetic pattern and metastatic characteristics.

For more information watch the full video here:
 https://youtu.be/oWpAK8i-VNw
medical illustration of CRUK scientists at UCL and the Francis Crick Institute have redefined kidney cancer into a total of seven different subtypes based on their genetic fingerprint. These seven different subtypes have a well defined genetic pattern and metastatic characteristics.
One tumour subtype is shown here, with different coloured regions indicating cellular subpopulations of different evolutionary branches.

For more information watch the full video here:
 https://youtu.be/oWpAK8i-VNw
medical illustration of In order to build a solid immune response, lymph nodes need to be flexible. This helps them expand when an army of immune cells is being created, and contract after those immune cells leave to fight infections.

Find out how this works in our animation:
https://youtu.be/oqpqZpluOag
medical illustration of Normally, the immune system is able to recognise neoantigen peptides on the surface of cancer cells. But in many lung cancers about half of the HLA proteins that present these neoantigens are missing, which makes it more difficult for the immune system to track cancer. 

Find out more in the full video here: https://youtu.be/txzpoAxw5nA

This image was used on the cover of Cell
http://www.cell.com/cell/issue?pii=S0092-8674(16)X0025-6
medical illustration of Normally, the immune system is able to recognise neoantigen peptides on the surface of cancer cells. But in many lung cancers about half of the HLA proteins that present these neoantigens are missing, which makes it more difficult for the immune system to track cancer. 

Find out more in the full video here: https://youtu.be/txzpoAxw5nA
medical illustration of Scientists usually study cancer by looking at a single layer of cancer cells in a dish. But the reality of the tumour microenvironment is much more complex. New techniques are finally letting scientists study the complex ways in which different cell types communicate with one another inside the microenvironment.

Watch our full video on this complex cell signalling here: https://youtu.be/6Q4TuLXBEpg
medical illustration of This image, based on the results of the TracerX  lung cancer trial by Prof Charles Swanton at the Francis Crick Institute and UCL, was used as the cover of Nature, vol 545 issue 7655 May 25th 2017
medical illustration of Not only is oncogenic KRAS able to kickstart all kinds of proliferative signalling pathways inside a cell, it's able to hijack the behaviour of nearby fibroblasts as well. This causes the fibroblasts to release growth factors, which cause even more proliferative signalling in the cancer cells. 

See our full video here: https://youtu.be/GU-QZp5FwM8
medical illustration of See our full video on blood cancer here: https://youtu.be/B8nFk5j2hP4
medical illustration of By engineering a patient's own immune cells to be better at targeting cancer, doctors are now able to make truly personalised treatments.

You can find our full video on CAR-T cells here: https://youtu.be/w7mMamTRvko
medical illustration of Complex cell signalling between cancer cells, fibroblasts and immune cells.

This image was used on the cover of Trends in Biotechnology vol 34 no 8 August 2016
medical illustration of When cells inside a tumour die, they break up into little bits that can get into the bloodstream. That means that scientists can filter out traces of tumour DNA from the bloodstream and use it to track cancer.

Watch our full video on liquid biopsies here: https://youtu.be/ZJyvqhVWQyM
medical illustration of When cells inside a tumour die, they break up into little bits that can get into the bloodstream. That means that scientists can filter out traces of tumour DNA from the bloodstream and use it to track cancer.

Watch our full video on liquid biopsies here: https://youtu.be/ZJyvqhVWQyM
medical illustration of Animation, Color, 3D, Multimedia, Web, Research, Cell biology / Histology, Molecular Biology, Oncology, Mechanism of Action (MOA)
medical illustration of Axumin, a new PET/CT reagent for imaging biochemically recurrent prostate cancer, is transported into the cell via amino acid transporters.

For more information about Axumin, and to watch the full video, please visit axumin.com
medical illustration of Find out more about tumour heterogeneity and how we can target it with next generation immunotherapy here: 

https://youtu.be/ETSarsv9QhA
medical illustration of Find out more about tumour heterogeneity and we can target it with next generation immunotherapy here: https://youtu.be/ETSarsv9QhA
medical illustration of A pseudo-DUB, artwork we did to promote the 2018 EMBO conference on pseudoenzymes 

meetings.embo.org/event/18-pseudoenzymes
medical illustration of RNAse L, artwork we did to promote the 2018 EMBO conference on pseudoenzymes 

meetings.embo.org/event/18-pseudoenzymes
medical illustration of To watch our 3-part series on therapeutic antibodies, for University College London:

Part 1, antibody structure/function: https://youtu.be/ptnjKYEEheo
Part 2, therapeutic antibodies: https://youtu.be/Rsv_Swx3tSA
Part 3, antibody-drug conjugates: https://youtu.be/QDXcsSF3yl0
medical illustration of To watch our 3-part series on therapeutic antibodies, for University College London:

Part 1, antibody structure/function: https://youtu.be/ptnjKYEEheo
Part 2, therapeutic antibodies: https://youtu.be/Rsv_Swx3tSA
Part 3, antibody-drug conjugates: https://youtu.be/QDXcsSF3yl0
medical illustration of This still is from a video we did based on Prof. David Nutt's work at Imperial College London, investigating the use of psychedelic drugs in the treatment of depression:

https://youtu.be/ltqjHHZr-yM
medical illustration of Find out more about how kinases transmit signals in our breakdown video here: https://youtu.be/xG2WOd_fWqo
medical illustration of Find out more about how kinases transmit signals in our breakdown video here: https://youtu.be/xG2WOd_fWqo
medical illustration of Watch our video on how the proteosome works here: https://youtu.be/TgOe7aPVpoM
medical illustration of Cartoon, Color, 3D, Web, Research, Cell biology / Histology, Molecular Biology, Oncology
medical illustration of Cartoon, Color, 3D, Web, Research, Cell biology / Histology, Molecular Biology, Natural Science / Nature, Mechanism of Action (MOA)
medical illustration of An accurate human shoulder: geometry isolated from an original MRI dataset, with added texturing.

Profile

At Phospho, we make your science stunning. We're a small team based in London, UK. We specialise in molecular, cellular, (immuno-)oncology, diagnostics and medical imaging visualisations, for charity, academia and industry partners. We're passionate about three things: making gorgeous imagery, telling engaging stories, and delivering the highest scientific accuracy. Most of our team have biochemistry PhDs, so we know how important it is to get the science absolutely spot on. We've posted some recent highlights here, but you can find much more on our website or youtube channel (youtube.com/phosphouk). If you have any questions or would like to discuss ideas for a project, don't be shy: drop us an email or get in touch via phospho.co.uk.

Style/Techniques

Animation, Cartoon, Color, Design, 3D, Models, Microscopy

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Cell biology / Histology, General Medicine, General Surgery, Genetics, Molecular Biology, Natural Science / Nature, Neuroscience, Neurosurgery, Orthopaedics, Pharmacology, Portraits, Urology, Virology, Oncology, Mechanism of Action (MOA), Pathology