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Sickle Cell Anemia MOD 

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Multiple Myeloma

medical illustration of Interpretation of Hemoglobin S polymerization. A genetic mutation causes the production of hemoglobin S (Hb S). When deoxygenated,  Hb S has the ability to polymerize into rigid rods which reshape the erythrocyte. The sickle shaped erythrocyte is much less flexible, which leads to hemolysis, increased viscosity and acute vaso-occlusive episodes.
Next medical illustration of Glasdegib is a Hedgehog signaling pathway inhibitor used to treat chemotherapy resistant AML (acute myeloid leukemia). Glasdegib molecule attaches to the Smoothened transmembrane protein and inactivates the Hedgehog signaling pathway. Glasdegib sensitives cells and reduces chemotherapy resistance.

AML Treatment with Glasdegib

Interpretation of Hemoglobin S polymerization. A genetic mutation causes the production of hemoglobin S (Hb S). When deoxygenated, Hb S has the ability to polymerize into rigid rods which reshape the erythrocyte. The sickle shaped erythrocyte is much less flexible, which leads to hemolysis, increased viscosity and acute vaso-occlusive episodes.

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