Journal of the Advanced Practitioner in Oncology


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Coronal section through the abdomen and chest showing a massive retroperitoneal liposarcoma in the abdomen of a middle aged male patient. Internal organs are shown displaced into the left hemi-abdomen.

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medical illustration of Viral infections remain a major complication after HSCT. Patient shown receiving an IV treatment of single valent VST with antigen-specific T cells. T cells activated by exposure to adenovirus (shown ghosted over image).
medical illustration of Mid-saggittal section through lumbar spine showing deletorious effects of multiple myeloma. Patient shown presenting with back pain.
medical illustration of Interpretation of Hemoglobin S polymerization. A genetic mutation causes the production of hemoglobin S (Hb S). When deoxygenated,  Hb S has the ability to polymerize into rigid rods which reshape the erythrocyte. The sickle shaped erythrocyte is much less flexible, which leads to hemolysis, increased viscosity and acute vaso-occlusive episodes.
medical illustration of Glasdegib is a Hedgehog signaling pathway inhibitor used to treat chemotherapy resistant AML (acute myeloid leukemia). Glasdegib molecule attaches to the Smoothened transmembrane protein and inactivates the Hedgehog signaling pathway. Glasdegib sensitives cells and reduces chemotherapy resistance.
medical illustration of Editorial image to highlight the important role of Pharmacists in the UK's largest ever vaccination program.
medical illustration of Background shows a lung CT showing lung metastasis. Overlaying graph show variation of target lesions over time, with pseudoprogression shown in yellow. Main image show t cell binding with tumor cell (tumor cell in pink, binding through action of Nivolumab, anti-PD-1) and then T cells binding to dendritic cell (dendritic cell in green, binding through action of Ipilimumab)
medical illustration of Damage to NTRK genes can lead to fusion proteins that cause unregulated cellular growth and differentiation because signaling cascades stay activated. The main illustration shows Larotrectinib binding to a dimerized TRKC fusion protein and consequently stopping the signal cascades that would have followed (indicated by faded out proteins)
medical illustration of Mechanism of action of Duvelisib (Copiktra); oral delta and gamma PI3K inhibitor. This dual isoform blockage inhibits cell signaling within malignant B cells and between malignant cells and the tumor microenvironment (TME). Blocking PI3K delta pathways from activated BCR, cytokine, and CD40 receptors affects the growth and survival of malignant B cells.
medical illustration of Part of a series for use in training pharmacy techs in order to educate their patients on the correct applications of various nasal medications
medical illustration of Illustration of circadian rhythm disorders that interrupt the normal sleep-wake cycle. Circadian rhythm is set by the suprachiasmatic nucleus of the hypothalamus. It projects to the pituitary gland to release melatonin to promote sleep.
medical illustration of Pharmacogenomics is the study of how genomic variation affects an individual's response to medications. This illustration shows the opioid and CYP2D6 gene pairing. CYP2D6 is found on chromosome 22. Background show gel electrophoresis with CYP2D6 stain.
medical illustration of Figurative study of patient after latissimus dorsi flap reconstruction for breast cancer.
medical illustration of Immune blockade immunotherapy for targeted cancer treatment. Monoclonal antibodies are given intravenously and work by targeting specific proteins found on the surface of the cancer cell. Once a cell is marked by a monoclonal antibody it becomes ‘visible’ to the immune system.
medical illustration of To accompany article about the need to standardize injection technique for subdermal injections of proteasome inhibitor bortezomib.
medical illustration of Cover illustration for an article on the importance of early detection of Vulvovaginal Graft v Host Disease (VVGvHD). Shown in the image is an affected genital tract overlay on a normal state. The labia minora and majora have experienced a loss of architecture, there are skin fissures present along with vaginal stenosis and adhesions. Overlaying graphic show cellular components of the disease including donor T cells, host APC, the JAK-stat pathway of the T cell, MHCII, and other immune cells.
medical illustration of Development of chronic pain and intractable cancer pain appears to be related to the activation of the NMDA receptors in certain areas of the central nervous system, especially the limbic system.
medical illustration of Kidney with overlay of nephrons showing methotrexate build-up in the collecting tubules.
medical illustration of Chemotherapy induced peripheral neuropathy (CIPN) illustrated with symmetrical stocking-glove numbness and paresthesia.
medical illustration of Simple Photoinduced Synthesis of Anilides
medical illustration of View of hands on a laptop with images related to patient care in obstetrics. Images include fetal heart rate, baby in utero with pregnant abdomen; ultrasound; blood pressure and vitamins.
medical illustration of Illustration showing flap reconstruction after mastectomy. The Latissimus dorsi pedicle is transferred from the shoulder to rebuild the breast mass. A saline implant is shown in the sub-pectoral position.
medical illustration of Deleterious mutations in the BCRA1 and BCRA2 genes are the most common cause of hereditary breast and ovarian cancer. Illustration shows dramatization of extraction of DNA from a blood test. Chromosomes 17 and 13 show the location of BCRA mutations leading to double DNA breaks.
medical illustration of Anterior view of the anterior muscles of the torso and arm. Showing pectoralis, rectus abdominis, deltoid, and biceps femoris.
medical illustration of Anterior view of fetus in utero showing basic anatomy of the lower great vessels with emphasis on the bifurcation of the aorta and the femoral veins. There is further compression of the iliac veins by the gravid uterus and the location of the right iliac artery over the left iliac vein. Hormonally mediated vein dilation is also shown. 78 to 90% of Venous Thromboembolisms occur in the left ilio-femoral vein.
medical illustration of Multiple images of male and female pelvic areas highlighted to show approximate incidence of chronic pelvic pain.
medical illustration of Illustration showing various methods of nausea control from chemo and radiation induced nausea and emesis.
medical illustration of Patient shown receiving injection of botulinum toxin in salivary glands in the days before surgery for esophageal cancer to manage hypersalivation.
medical illustration of Cardiotoxicity resulting in decreased ventricular function. AP view of heart with left ventricular dysfunction and Qtc prolongation.
medical illustration of Midsagittal view of the brain showing a close up of the hypothalamus. The hypothalamus controls the circadian rhythms that guide the body’s natural sleeping and waking cycles. Highlighted are the suprachiasmatic nucleus (in yellow) which sets basic circadian rhythms, the pre optic are (in lavender)  which controls slow wake sleep, and the posterior hypothalamic nucleus (in blue) which promotes wakefulness. Overlaying ECG patterns show a waking state, deep sleep and REM sleep.
medical illustration of Lateral view of facial muscles showing six common branching patterns of facial nerve
medical illustration of Intraoperative view of salpingectomy
medical illustration of Illustration of generalized pain showing the back of a patient. Posterior view of cerebellum, spinal cord, and brachial plexus.
medical illustration of Illustration showing prostate cancer to accompany article about androgen deprivation therapy
medical illustration of Mid-saggittal section through lumbar spine showing deletorious effects of multiple myeloma. Patient shown presenting with back pain.
medical illustration of Midsaggital view of the brain showing the Trigeminovascular pathway that is activated by an abrupt drop in estrogen.
medical illustration of Sequential illustration showing descent of fetal head through Levator Ani muscle and consequent stretch of muscle to accommodate delivery of baby.
medical illustration of Montage of images related to Lynch syndrome including endometrial cancer, a family pedigree for an autosomal dominant syndrome and a segment of dna showing high microsatellite instability.
medical illustration of ECV (external Cephalic Version) in use to try and avoid Cesarean section on a mother with a fetus in complete breech presentation. The baby is lifted out of the pelvic cavity and rotated head down.
medical illustration of Acupuncture needle positions for treatment of various sinus related issues.
medical illustration of Illustration for article about the diagnosis and management of abnormal placentation. Shown is disrupted decidua basalis layer with ingrowth into the decidua and myometrium of the uterus. Large placental lacunae are seen on the cross section. Uterine scarring is also demonstrated near the most pervasive areas of placenta abnormality.
medical illustration of Close up view of the pupil and iris showing reflections of a computer screen and cityscape for an article on dry eye.
medical illustration of Medical illustration showing insertion of 3 mm mini trochar next to previously placed 5-12 mm versa port in umbilicus. Abdomen is insufflated and draped for pelvic surgery.
medical illustration of Editorial illustration on the current US Cesarean section epidemic and its implications. Surgeon is shown pausing  before preforming a cesarean section. Patient is shown in cross section, stalled in early phase two labor.
medical illustration of Internal Cystitis and Bladder Pain Syndrome is a common cause of chronic pelvic pain. The illustration show glomerulations, thinned and/or irregular areas of the glycosaminoglycan (GAG) layer with general irritation in the urothelium during a cystoscopy. Pelvic nerves in the surrounding tissue are inflamed.
medical illustration of Maternal obesity and high gestational weight gain may have harmful effects on fetal metabolic programming and potential harmful effects on the fetal brain. Evidence suggests increased odds of cognitive defect, increased odds of autism spectrum disorder, ADHD, and cerebral palsy. Mechanisms may be through inflammation via increased pro-inflammatory cytokines, fetal pancreatic response to glucose rich environment and multiple organs affected include fetal brain, liver, pancreas and adipose tissue.
medical illustration of Breast cancer from diagnosis to typing.
medical illustration of Illustration for article comparing various methods of inserting the first trochar to avoid injury in laparoscopic surgery
medical illustration of Main illustration shows marrow punch inserted into posterior superior iliac spine (PSIS) to collect biopsy sample. Inset illustration shows patient positioning.
medical illustration of Illustration showing the Whipple Procedure - a pancreaticoduodenectomy. In this, the head of the pancreas, antrum of the stomach and duodenum are removed en bloc. The gall bladder is also removed. The common bile duct and tail of the pancreas are sutured to the jejunum. The stomach is redirected to empty below the pancreas and bile duct into the jejunum. Shown through the stomach is the tail of the pancreas with ghosted in main pancreatic duct, and splenic artery.
medical illustration of Illustration showing robotic partial nephrectomy with a laparoscopic assist. Kidney and tumor come out of a coronal CT scan. Bulldog clips are applied to the renal vessels to allow work in a bloodless field.
medical illustration of Editorial illustration of baby in utero exhibiting gastroschisis with some inflammation of the midgut (jejunum and ileum) from exposure to the amniotic fluid.
medical illustration of Embryo biopsy in IVF for genetic analysis is a shift in standard therapy over controlled ovarian hyperstimulation with intrauterine insemination as first-line therapy for couples with unexplained fertility.
medical illustration of Midsagittal section of fetus in utero showing hydrops fetalis.
medical illustration of Retroperitoneal lymph node dissection for treatment of testicular cancer. Abdominal lymph nodes are removed to establish stage and type. Testicular cancer spreads in established pattern. The article includes two inside pieces showing a modified patter for the left and right patterns of spread.
medical illustration of Internal view of a capillary showing the effects of chronic inflammation. Destruction of the vessel wall can be seen in the lower left side of the image, along with an increase of fibrinogen strands in the blood.
medical illustration of Psychomotor Dysadaptation Syndrome. A postural and psychological problem seen in the frail and very elderly. The fear of falling will bring about postural changes in the spine and core muscles.
medical illustration of Illustrates a sagittal section of lumbar spinal anatomy showing a permanently placed catheter for delivery of pain medication directly into the thecal sac and spinal fluid for severe, chronic pain management in end stage cancer.
medical illustration of Illustration showing future of bladder augmentation. Shown is a scaffold of SIS material (small intestine submucosa which is biodegradeable and supports three dimensional cell growth) seeded with stem cells in vitro.
medical illustration of Infographic on the history, mechanism and use of oral contraceptives. Layout design by Maria Gonzalez.
medical illustration of Surgical View of Facial Nerve Branches


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