Audra Geras

The Weber Group

The Gut Microbiome and Multiple Sclerosis 

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Current Areas of Research in Dermatology

medical illustration of This image was created for the cover of the Journal of Clinical Investigation. It shows how epsilon toxin molecules released from Clostridium perfringens strain B/D in the gut microbiome assemble into pores in the endothelial cells of blood-brain-barrier capillaries disrupting the integrity of the BBB. This disruption allows the infiltration of myelin autoreactive CD4+ T cells into the brain parenchyma, leading to the demyelination of neurons.
Next medical illustration of This 3D illustration takes a dramatic view of chromosome pairs being pulled apart by the microtubules of the mitotic spindle during cell division.

Mitosis

This image was created for the cover of the Journal of Clinical Investigation. It shows how epsilon toxin molecules released from Clostridium perfringens strain B/D in the gut microbiome assemble into pores in the endothelial cells of blood-brain-barrier capillaries disrupting the integrity of the BBB. This disruption allows the infiltration of myelin autoreactive CD4+ T cells into the brain parenchyma, leading to the demyelination of neurons.

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