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Biotechnology firm specializing in immunotherapy

SIRPalphaFc Binding to FcgammaR and CD47

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This painting was created as a large format illustration for multi-use, including as a fine art giclée canvas print to be on permanent exhibit at the headquarters of a biotechnology firm. It depicts the binding of the investigational fusion protein SIRPalphaFc to FcgammaR on a macrophage cell and to CD47 receptors on a tumor cell.

2016 Audra Geras

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Audra Geras

Represented by

The Weber Group

medical illustration of This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.
medical illustration of This conceptual illustration dramatically depicts a double-stranded DNA break. The client's drug functions to prevent DNA repair by PARP.
medical illustration of This 3D illustration, created for a biotechnology client, depicts the processes of ubiquitination and protein degradation. Ubiquitination is a necessary first step in the degradation of no-longer-needed proteins into short strands of amino acids by the 'molecular sawmills' known as proteasomes.
medical illustration of This highly conceptual 3D illustration was created for an investigational amyloidosis drug. The client wanted to dramatically show the presence of abnormal amyloid peptide molecules and blast cells in the bone marrow of amyloidosis patients.
medical illustration of This illustration depicts the aerial fungal hyphae and reproductive sporing bodies of several common dermatophytes or skin fungi. I chose to create this scene as a 3-dimensional illustration, and in a glass-like material, to emphasize the translucent and jewel-like appearance of these organisms.
medical illustration of This 3D image shows a renal environment and features the structure of the basic filtration unit of the kidney, the glomerulus.
medical illustration of This diptych was created for a biotechnology firm. The first image shows the phagocytosis and digestion of a tumor cell. The second shows the further degradation of tumor cell fragments into short peptide strands by a proteasome, followed by the processing and presentation of tumor antigen to a T cell.
medical illustration of This 3D image was designed to show the delivery of a cancer drug using nanotube technology.
medical illustration of This illustration was created to showcase the use of fullerene structures as 'cages' that can be used as a drug delivery system..
medical illustration of This 3D illustration was created for a biotechnology firm. It shows monoclonal antibodies binding to molecules of the specific ligand they were designed to target.
medical illustration of This 3D glass cell was created as both large scale print art and as part of an animation on lysosomal disease. It was featured prominently at a conference..
medical illustration of This illustration shows the anatomical locations of the major bursae of the shoulder's rotator cuff. It was created as an editorial piece on the subject of inflammation of the bursae.
medical illustration of This highly conceptual 3D illustration symbolizes the devastating effect of amyloidosis on the heart. The hand squeezing the heart is composed of amyloid fibrils. The image was created for the marketing of an investigational amyloidosis drug.
medical illustration of This image featuring strands of DNA was created as one of a series of 3D illustrations for a biotechnology firm.
medical illustration of This is one of a very large series of illustrations on cells in which the featured cell(s) has been rendered in full color while the background is in B&W halftones. The cells shown here are osteoclasts involved in the resorption of bone.
medical illustration of This 3D illustration of the limbic system places the focus on the amygdalae, two small pea-shaped structures on either side of the limbic system, that play a crucial role in the processing of emotional memory and experiences, including fear and anxiety. The amygdalae serve as a guage able to detect the degree of danger in our environments. They are central to the inappropriate reactions experienced by people who suffer from chronic phobias, obsessions and generalized anxiety.
medical illustration of This 3D image shows the brain and three different orientations of the limbic system rendered in a glassy material. It was created for a pharmaceutical client.
medical illustration of This 3D illustration was created for a biotechnology firm as a large format fine art painting on the subject of epigenetics. It depicts the role of histone 'tail' acetylation in the conversion of DNA from its heterochromatin state to its looser euchromatin state.
medical illustration of This 3D illustration depicts a dramatic view of spermatozoa traveling within the lumen of a uterine (Fallopian) tube. The lumen is lined by secretory epithelial cells interspersed with ciliated columnar cells.
medical illustration of This illustration depicts the action of a drug used to promote platelet production by megakaryocytes.
medical illustration of This 3D illustration takes a dramatic view of chromosome pairs being pulled apart by the microtubules of the mitotic spindle during cell division.
medical illustration of This illustration depicts the appearance of Trypanosome brucei protozoa within the bloodstream. T.brucei causes a lethal African illness known as 'sleeping sickness'. The image was created for editorial usage.
medical illustration of This illustration shows a Trypanosome bruceii organism in the blood stream and the immune response to variant surface glycoproteins (VSGs) on the Trypanosome cell membrane. VSGs trigger an immune response via pentameric Immunoglobulin M antibodies. Trypanosome bruceii causes African sleeping sickness.
medical illustration of This view into a synapse was created for a biotechnology firm. It depicts the release of GABA neurotransmitter molecules from presynaptic vesicles, and their binding to the GABAa receptor pentamer in the postsynaptic membrane.
medical illustration of This illustration on the subject of pediatric asthma shows the extravasation of inflammatory cells involved in the initiation of an an asthma attack, and the release of biologically active molecules into the environment. It was created for a global pharmaceutical client.
medical illustration of The illustration shows part 1 of the mode of action of SIRP-alpha Fc in triggering tumor cells to give off an 'eat me' signal to phagocytic macrophages. This painting is the first  half of a 120
medical illustration of The illustration shows part 2 of the mode of action of SIRP-alpha Fc: the presentation of tumor antigens to CD8+T cells leading to the proliferation of cytotoxic T cells that are capable of triggering apoptosis of the tumor cells through their release of cytotoxins. This painting is the second half of a 120
medical illustration of This is one of a very large series of illustrations on cells in which the featured cell(s) has been rendered in full color while the background is in B&W halftones.
medical illustration of SHORT-LISTED for the 2016 WORLD ILLUSTRATION AWARDS. (Finalists as yet unannounced.) 
This 3-dimensional illustration shows the inflammatory environment of the papillary dermis as seen from beneath the epidermis in the early stages of psoriatic plaque development. This image was also used as the stylistic guide for a 3D animated video that our studio, Geras Healthcare Productions, created for a major pharmaceutical drug launch.
medical illustration of This 3D scene features cells in the papillary dermis of the skin that are known to express interleukin-17A (IL-17A), a key proinflammatory molecule involved in the pathogenesis of plaque psoriasis. The cells shown are: fibroblasts, keratinocytes, endothelial cells and a macrophage.This image is derived from a 3D video created by Geras Healthcare Productions for a major pharmaceutical drug launch.
medical illustration of This 3D image represents the ability of a fluorinated epilepsy drug to cross the 'blood brain barrier' (BBB). The BBB components shown include: pericytes encircling a capillary at the brain interface, astrocyte foot pads, and the basal lamina surrounding the BBB complex. The image was created as a large scale mural for a biotech firm.
medical illustration of This 3 dimensional instructional illustration depicts the structures that comprise the blood-brain-barrier. It was created for a biotechnology firm.
medical illustration of This fully 3D illustration displays a network of pyramidal neurons in the brain. The illustration was created for a global pharmaceutical client.
medical illustration of This is a dramatic conceptual image of an ovum and its surrounding corona radiata.
medical illustration of This is a selection of 3 illustrations showing the same subject matter, the heart, depicted in 3 different styles - traditional, conceptual and high tech 3D. I created this montage to demonstrate that biomedical artists have the skills needed to create custom visuals in diverse styles. If the style of art you are seeing is not exactly what you had in mind, but you like the quality of the work, tell us what you are envisioning. Chances are that the look you want is no obstacle.
medical illustration of This is an illustration that was created for a biotechnology firm to show the process of epithelial mesenchymal transition (EMT), whereby tumor cells lose contact inhibition and become mobile, a key first step in metastasis of cancer.
medical illustration of These 3 views of a face were designed to show the most common facial characteristics of an Asian-Pacific woman. The illustrations formed the base art for a series of illustrations depicting the detailed anatomy of the face. The art was created for the Asian-pacific Botox market.
medical illustration of This series of illustrations showing the detailed anatomy of the face were created for the Asian-Pacific Botox market.
The facial anatomy shown includes: the skull, blood vessels, nerves, muscles and fat pads
medical illustration of This illustration shows the generation of a molecular signal transduction cascade triggered by the binding of interleukin-17A (IL-17A) to its cell membrane receptor. It also shows the blockade of this cascade by the binding of monoclonal antibodies directed against IL-17A, a key molecule involved in the pathogenesis of several serious inflammatory diseases.
medical illustration of This illustration received the RX Club Award of Excellence, as well as the Society of Los Angeles Illustrators Award of Merit. It depicts the cell interior with a view upwards towards the cell membrane through which cytotoxic signals are penetrating the cell. The illustration is derived from a 3D animated video describing the role of mitochondrial proteins in the induction of apoptosis. Both the illustration and the video were created for a pharmaceutical client.
medical illustration of This illustration received the RX Club Award of Excellence. It depicts a view downwards to the nucleus from inside a cell. The illustration is derived from a 3D animated video describing the role of Bcl-2 family mitochondrial proteins in the induction and inhibition of apoptosis. Both the illustration and the video were created for a global pharmaceutical client.
medical illustration of This 3D illustration depicts the pain associated with the impingement of a cervical nerve root, in this case at C5, due to a vertebral subluxation.
medical illustration of This 3D illustration represents the pain associated with the impingement of a lumbar nerve root, in this case at L3, due to a vertebral subluxation.
medical illustration of This illustration received the RX Club Award of Excellence. It depicts the Nevo Sirolimus-eluting coronary stent. The image was designed to show the unique cobalt chromium structure and design of the stent, as well as the exceptional flexibilty and conformity of the stent architecture. The drug, Sirolimus, is released from dozens of fully biodegradable polymer wells which dissolve to leave behind a strictly bare metal stent with thin flexible struts.
medical illustration of This 3D illustration shows the early stages in the formation of a plaque-induced blood clot or thrombus. Damage to the endothelial cells lining the blood vessel lumen exposes a variety of platelet-activating factors, including collagen fibres, to the circulating blood. Platelets coming into contact with these factors adhere to the plaque surface and undergo dramatic morphologic changes. This is the first step in the initiation of a complex coagulation cascade leading to thrombus formation.
medical illustration of This 3D image was displayed in a pharmaceutical exhibit at a conference focused on lysosomal diseases. It features the molecule, alpha-galactosidase A, which is deficient in Fabry disease. Fabry disease is a rare genetic lysosomal storage disorder.
medical illustration of This diagrammatic illustration depicts the cellular and molecular pathway involved in the pathogenesis of Gaucher Disease, an inherited metabolic disorder that leads to the accumulation of  the lipid glucocerebroside in cells and certain organs. Gaucher disease causes the deficiency of an enzyme, glucocerebrosidase, that normally breaks down and recycles this lipid.
medical illustration of This is a conceptual illustration depicting VEGF (vascular endothelial growth factor) molecules in the blood stream.
medical illustration of This advertising illustration depicts the normal branching of the bronchioles in the lungs and features a magnified view of a bronchiolar cross-section, as well  as of alveoli and their surrounding blood vessels. It was printed as a poster for a global pharmaceutical firm.
medical illustration of This illustration was created for a global pharmaceutical company as part of a series of images on rheumatoid arthritis. The illustration shows the progressive damage to the articular cartilage and bone of the head of the femur.
medical illustration of This illustration received the RX Club Award of Excellence. It depicts an osteoclast cell within the matrix of cancellous bone. The illustrated cell is shown in its activated state in which it has developed the characteristic 'brush border' that secretes acid and enzymes involved in the decalcification and resorption of underlying bone. The smaller cells in the background are osteoblasts involved in the formation of new bone tissue.
medical illustration of This illustration was created as a large scale mural and exhibit panel for a global pharmaceutical firm. It represents a vertical section taken through a synovial joint damaged by rheumatoid arthritis. The major events in the pathogenesis of rheumatoid are shown.
medical illustration of This advertising illustration depicts a neuron or nerve cell and features a detailed look at a single synapse.
medical illustration of The illustration shows the normal stages in the birth of a child. It was created as a patient education series for Lamaze International.
medical illustration of This illustration is one of a series of illustrations that was created for a firm specializing in dermatology products. The series depicts the formation of Prosomes, a patented treatment delivery system that is able to deliver kinetin and zeatin molecules deep into the skin. Geras Healthcare Productions also created a 3D animated video describing this technology.
medical illustration of This painting received an Rx Club Award of Excellence. It was designed for a manufacturing firm.  It demonstrates the effect of photodynamic therapy on the vasculature of prostate tumours. Damage to the vessels feeding the tumours results in cancer cell death and tumour shrinkage.
medical illustration of This editorial illustration depicts the interior of the right ventricle of the heart. It also shows the right bundle branch of the heart's conduction system including the small fibres that feed the papillary muscles.
medical illustration of This is an editorial illustration depicting the exterior of a normal eye. It was paired with a second illustration showing the appearance of an eye with conjuctivitis.
medical illustration of This illustration received the RX Club Award of Excellence. It is a modified still extracted from a 3D mode-of-action animated video created by Geras Healthcare Productions. It was used in print materials associated with the drug Lucentis. The illustration shows the pathologic changes to the macula, retina and choroidal blood vessels typical of advanced wet age-related macular degeneration (wet AMD).
medical illustration of This pharmaceutical poster was published as a limited, signed edition and was used as a promotional give-away. It describes the pathogenesis of glaucoma.
medical illustration of This dramatic 3D illustration features a bovine egg cell or ovum and approaching spermatazoa. It was created for a client specializing in the discovery, development and manufacturing of animal health products worldwide. The image was designed as an exhibit mural for a veterinary conference. A horizontal version of this image was used as a 60 ft. banner spanning the width of the exhibit booth.
medical illustration of This is a conceptual illustration designed to represent the tragically common inability of cancer therapies to prevent the metastasis and progression of cancer.
medical illustration of This image is a
medical illustration of This illustration shows the correct method of insertion insertion and positioning of four commonly-used Laryngeal Mask Airways. It was created for the device manufacturer.
medical illustration of This illustration shows the correct positioning of the new Supreme Laryngeal Mask Airway. It was created for the device manufacturer.
medical illustration of This illustration was created as an advertising poster for Omnaris nasal spray, a drug used in the treatment of nasal allergies and hay fever. The client wished to show the distribution of the drug particles within the upper respiratory system.
medical illustration of The illustration shows the structure and function of the Turbuhaler, a device designed to deliver asthma medication. The details of its function were also demonstrated in a 3D animated video.
medical illustration of This is a selection of 3D product/health-care related models that we have created for a variety of clients. Geras Healthcare Productions has a history of technical model-making and animation that extends beyond the healthcare field and encompasses a diverse range, including tool and dye manufacturers, the car industry, and more.
medical illustration of This is a selection of 3D product/health-care related models that we have created for a variety of clients. Geras Healthcare Productions has a history of technical model-making and animation that extends beyond the healthcare field and encompasses a diverse range of subjects, including tool and dye manufacturers, the car industry, and more.
medical illustration of This is a 3D model I created for use as a logo by our studio, Geras Healthcare Productions. It has been rendered in 2 different styles; naturalistic and in a glass-like material. The concept references the saying 'as alike as three peas in a pod
medical illustration of This pharmaceutical illustration shows the gross anatomical changes to the brain tissue as a result of brain shrinkage.
medical illustration of This pharmaceutical illustration was designed for use as a patient/physician education poster providing a general overview of the causes and dangers of atrial fibrillation. It also features the normal anatomy of the heart.
medical illustration of This painting is one of 50 illustrations created for the book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. It was also printed as a poster and large scale mural.The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. I chose to depict this as a Grand Canyon-like cut-away revealing the architecture of the skin.
medical illustration of This poster illustration was created for the launch of the antifungal drug Lamisil. It is also one of 50 illustrations in my book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. The image shows the characteristic clinical appearance of common fungal infections of the skin and hair, as well as the typical fungal morphology and appearance in culture.
medical illustration of This painting is one of 50 illustrations created for the book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. This image was also printed as an educational poster and was used in the launch of the drug Lamisil. It shows the clinical features of
medical illustration of This panel depicting a range of acne lesions was created for a pharmaceutical firm for use in a variety of media.
medical illustration of This painting is one of 50 illustrations created for the book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. This image demonstrates the important features of a typical melanocyte in the epidermis of the skin. The distribution and arrangement of the melanin pigment is of particular interest.
medical illustration of This is a conceptual illustration created for a pharmaceutical company. It depicts a few of the common dermatophytes or skin fungi that can infect the scalp and hair.
medical illustration of The illustration shows how Aldara triggers an immunotherapeutic response to the abnormal cells of a basal cell carcinoma. Both activated dendritic cell and macrophage involvement are highlighted.
medical illustration of The illustration compares drug dispersal patterns associated with the use of injection versus transduction delivery methods. It was created for the transduction device manufacturer. The device is designed for use in the treatment of diabetes.
medical illustration of This is one illustration from a series of visuals that I created for a pharma ad agency. It shows the role of interleukin 6 (IL-6) on synovitis (inflammation of joint synovial tissue). The series won the RX Club Award of Excellence.
medical illustration of This is one illustration from a series of visuals that I created for a pharma ad agency. It shows the effect of interleukin 6 (IL-6) on synovial fibroblasts. The series won the RX Club Award of Excellence.
medical illustration of This was created as a patient education poster for a pharmaceutical client. It illustrates the major features of the respiratory system. It also includes spot illustrations depicting sinusitis, pneumonia and bronchitis.
medical illustration of This collection of images was created for a patient education poster, The Genitourinary System,  published by a pharmaceutical firm.
medical illustration of This is a montage of selected anatomical illustrations dealing with skeletal, bone and joint structures. The individual spots have been used in a variety of print materials including patient education posters, flip charts and brochures.
medical illustration of This is a patient education illustration showing the basic anatomy of the kidney, as well as enlarged views of a kidney pyramid and nephron.
medical illustration of This is derived from a larger pharmaceutical poster depicting the anatomy of the female genitourinary system.
medical illustration of This medical illustration depicts the different types of fibroids that may be found in the uterus. It also shows a section though the endometrium, and the pituitary gland within a ghosted brain. It was created for an advertising agency.
medical illustration of This series of anatomical illustrations was created for a pharmaceutical firm. They were part of a series of 20 illustrations relating to prostate gland health. This selection of images shows both the normal male reproductive/urinary anatomy as well as urinary retention caused by benign prostatic hypertrophy.
medical illustration of This is a small selection of traditional anatomical illustrations that were created for a variety of print materials. Shown are: the liver, the duodenum with pancreas, and the stomach.
medical illustration of This is one of a series of anatomical paintings of musculoskeletal subjects created for a pharmaceutical flip chart. The illustration shows the musculature of the knee.
medical illustration of This is one of a series of anatomical paintings of musculoskeletal subjects created for a pharmaceutical flip chart. The illustration shows the musculature of the foot.
medical illustration of This painting is one of 50 illustrations created for the book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. The illustration depicts the normal structure of the pilar apparatus, which includes: hair follicle, eccrine sweat gland, and erector pili muscle.

Profile

Audra Geras is an internationally renowned biomedical artist with degrees in both biology and visual biocommunications from the University of Toronto. She heads Geras Healthcare Productions, a boutique visual biomedical communications studio specializing in the creation of innovative custom illustration and 3D animated videos. Audra is a visual storyteller dedicated to finding successful solutions to medical and scientific communication challenges with clear, accurate and beautiful visuals.

Style/Techniques

Animation, Airbrush, Color, Design, Information Graphics, 3D, Apps/Mobile, Models, Microscopy

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Botany, Cardiac Surgery / Cardiology, Cell biology / Histology, Dermatology, Disease Management, Emergency Medicine, Endocrinology / Metabolic, Gastroenterology, General Medicine, General Surgery, Genetics, Maternal / Child, Medical Devices, Molecular Biology, Natural History, Natural Science / Nature, Neuroscience, Neurosurgery, Obstetrics / Gynecology, Ophthalmology, Orthopaedics, Pediatrics, Pharmacology, Physical Therapy, Reconstructive Surgery, Portraits, Reproductive Biology, Respiratory, Thoracic Surgery, Transplantation Surgery, Urology, Vascular Surgery, Veterinary Medicine, Injuries, Oncology, Mechanism of Action (MOA), Health & Wellness, Hemophilia, Pathology, Sports Medicine