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Trichomoniasis

Audra Geras

The Weber Group

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This 3D bioscape features a very common STD known as trichomoniasis that is caused by the single-celled parasitic organism Trichomonas vaginalis. The organism has a pear-shaped trophozoite form when not in contact with male or female urogential tract epithelium, but once it touches a host cell it assumes a closely-applied amoeboid form that is cytotoxic, causing inflammation and host tissue damage. The 'frothy' exudate spilling over the epithelial cells is characteristic of trichomoniasis.

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Represented by

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medical illustration of This 3D bioscape features a very common STD known as trichomoniasis that is caused by the single-celled parasitic organism Trichomonas vaginalis. The organism has a pear-shaped trophozoite form when not in contact with male or female urogential tract epithelium, but once it touches a host cell it assumes a closely-applied amoeboid form that is cytotoxic, causing inflammation and host tissue damage. The 'frothy' exudate spilling over the epithelial cells is characteristic of trichomoniasis.
medical illustration of This is image is one from a series of immunology-related illustrations. It shows the assembly process and transfer of MHC Class 1 molecules into the cell membrane of a dendritic cell (top right).
medical illustration of This image is one from a series of immunology-related illustrations. It depicts the release of perforin and granzyme molecules from vesicles in a cytotoxic CD8+ T cell, the assembly of the perforin molecules into pores in the cell membrane of a tumor cell, which then allows the entry of the granzyme molecules. This results in the killing of the tumor cell (bottom right).
medical illustration of This is image is one from a series of immunology-related illustrations. It provides a close-up view of the presentation of tumor antigen by an MHC Class 1 molecule to a T cell receptor (TCR). This results in the activation of the T cell.
medical illustration of This image is one from a series of immunology-related illustrations, It shows the arrival of cytotoxic CD8+ T cells at the site of a tumor. These cytoxic T cells have been primed to specifically recognize the abnormal cells and kill them via the release of cytoxic molecules that trigger apoptosis.
medical illustration of This 3D illustration depicts the detailed anatomy of a renal glomerulus inside its Bowman's capsule. It also shows the release and coalescence of urine droplets which leave the enclosed space via the proximal convoluted tubule at the top left.
medical illustration of This 3D image shows a renal environment and features the structure of the basic filtration unit of the kidney, the glomerulus.
medical illustration of This 3D illustration depicts neutralizing antibodies specific to COVID-19 as they bind to the membrane spike proteins on the surface of the virus.
medical illustration of This is a scientific illustration depicting an unusual sea creature known as a leafy sea dragon, Phycodorus eques. The male dragon is the one carrying a cluster of eggs on its underside. The dragons were sculpted in 3D and composited to create a 2D illustration.
medical illustration of This 2D/3D panel was created for a firm specializing in the development of chemical components used in a variety of cosmetic and skin care products. The seven areas of research that are their current focus are represented in the superimposed spot images.
medical illustration of This image was created for the cover of the Journal of Clinical Investigation. It shows how epsilon toxin molecules released from Clostridium perfringens strain B/D in the gut microbiome assemble into pores in the endothelial cells of blood-brain-barrier capillaries disrupting the integrity of the BBB. This disruption allows the infiltration of myelin autoreactive CD4+ T cells into the brain parenchyma, leading to the demyelination of neurons.
medical illustration of This 3D illustration takes a dramatic view of chromosome pairs being pulled apart by the microtubules of the mitotic spindle during cell division.
medical illustration of This 3D panorama depicts a microscopic section taken through a synovial joint showing some of the characteristic features of rheumatoid arthritis. The concept and image were developed for a major pharmaceutical firm.
medical illustration of This 3D illustration depicts the inner nuclear layer (INL) of the retina. It is one of a series of related images, including a very tall narrow mural showing the layers of the entire retina.
medical illustration of The illustration compares the efficacy of standard mesh HVAC filters versus heated nickel HVAC filters in the filtration and destruction of COVID-19 particles.
medical illustration of The story depicted here takes place in a bone marrow cavity within cancellous bone. It shows one of the leading theories regarding how specialized cells called megakaryocytes produce platelets. Two megakaryocytes have extended pseudopods into the interior of a sinusoidal capillary. The granular swellings along the lengths of the pseudopods are platelets-to-be. Within the capillary these swellings break off through a budding process to become free platelets.
medical illustration of This 3D illustration depicts a dramatic view of spermatozoa traveling within the lumen of a uterine (Fallopian) tube. The lumen is lined by secretory epithelial cells interspersed with ciliated columnar cells.
medical illustration of This 3D illustration, created for a biotechnology client, depicts the processes of ubiquitination and protein degradation. Ubiquitination is a necessary first step in the degradation of no-longer-needed proteins into short strands of amino acids by the 'molecular sawmills' known as proteasomes.
medical illustration of This 3D interpretation of a Dendritic Cell Interacting with a Tumor Cell was created for a biotechnology firm and has had a broad variety of uses, including iconic representation of the firm, and as a fine art giclée on canvas on permanent exhibit at the firm.
medical illustration of This is part of a 3D illustration that was created for a biotechnology firm to show the difference between nucleosome-protected circulating tumor DNA (ctDNA) and nucleosome-protected cell-free DNA (cfDNA).
medical illustration of This image takes an editorial approach. It depicts nucleosome-protected circulating tumor DNA (ctDNA), as well as cell-free DNA (cfDNA). The tumor DNA is being released into the circulation upon death of a tumor cell (by apoptosis). It important as a possible target for cancer screening.
medical illustration of This dramatic 3D illustration of the lungs features a magnified view of a bronchiole in cross-section.
medical illustration of This illustration depicts the aerial fungal hyphae and reproductive sporing bodies of several common dermatophytes or skin fungi. I chose to create this scene as a 3-dimensional illustration, and in a glass-like material, to emphasize the translucent and jewel-like appearance of these organisms.
medical illustration of The purpose of this illustration was to show one potentially serious consequence of atrial fibrillation. Atrial fibrillation creates turbulence in the heart that may result in thrombus (blood clot) formation. The thrombus can then travel to the brain where it may block a blood vessel causing oxygen starvation and tissue death. This is known as an ischemic stroke.
medical illustration of This 3D image was designed to show the delivery of a cancer drug using nanotube technology.
medical illustration of This is a 3D conceptual illustration on the subject of neuroplasticity, Neuroplasticity is the name given to the ability of our brain's neurons to form new connections throughout our lifetimes. This includes replacing abnormal or unhealthy neural pathways with more positive pathways under the right influences. The blossoming neuron is symbolic of positive neuroplastic growth.
medical illustration of This ophthalmologic image depicts the flow of aqueous humour into the anterior chamber of the eye and out through the trabecular meshwork surrounding the perimeter of the chamber.
medical illustration of This is a 3D mural I created for the new research facility recently built by Bella Aurora Laboratories in Barcelona, Spain. The 12 ft. image was printed on fabric and is backlit. It is now on permanent display in one of the Bella Aurora Labs meeting rooms.
medical illustration of This is a close-up view of the 3D image used in the mural (image preceding this one).
medical illustration of This is one of a very large series of illustrations on cells in which the featured cell(s) has been rendered in full color while the background is in B&W halftones. The cells shown here are osteoclasts involved in the resorption of bone.
medical illustration of This marketing illustration was created to announce a new dental implant procedure.
medical illustration of MAC are formed during the process of antibody-mediated complement activation. As this complex of complement proteins forms on the surface of a plasma membrane, it assumes a twisted cylindrical shape punching a pore through the membrane. The formation of MAC molecular complexes is most often targeted to the cell membranes of pathogens. Because MAC pores allow an unregulated free flow of molecules in and out of the plasma membrane they cause lysis and death of the pathogen.
medical illustration of This conceptual illustration dramatically depicts a double-stranded DNA break. The client's drug functions to prevent DNA repair by PARP.
medical illustration of Membrane Attack Complexes (MAC) form as a result of complement activation, assembling on the surface of plasma membranes. These molecular complexes assume a twisted cylindrical shape punching pores through cell membranes. The formation of MAC molecular complexes is most often targeted to pathogens. This 2D/3D image shows the lysis of bacteria caused by the unregulated free flow of molecules in and out of the plasma membrane through MAC pores.
medical illustration of This highly conceptual 3D illustration was created for an investigational amyloidosis drug. The client wanted to dramatically show the presence of abnormal amyloid peptide molecules and blast cells in the bone marrow of amyloidosis patients.
medical illustration of This 3D glass cell was created as both large scale print art and as part of an animation on lysosomal disease. It was featured prominently at a conference..
medical illustration of This 3D image is one of a series of paintings created for a biotech firm. It depicts the binding of SIRPalphaFc, an immunotherapeutic fusion protein, to the Fcgamma receptor on a macrophage and CD47 receptors on a tumor cell. SIRPalphaFc shuts off CD47's 'Do Not Eat' signal allowing macrophages to identify and phagocytize tumor cells.
medical illustration of This macabre conceptual illustration depicts a COVID-19 virus binding to ACE-2 receptors on the surface of a human cell. The scary-looking grasping hands represent the viral membrane spike proteins, the proteins that bind (in this case grasp) to the ACE-2 human molecules.
medical illustration of This diptych was created for a biotechnology firm. The first image shows the phagocytosis and digestion of a tumor cell. The second shows the further degradation of tumor cell fragments into short peptide strands by a proteasome, followed by the processing and presentation of tumor antigen to a T cell.
medical illustration of This illustration on the subject of pediatric asthma shows the extravasation of inflammatory cells involved in the initiation of an an asthma attack, and the release of biologically active molecules into the environment. It was created for a global pharmaceutical client.
medical illustration of This illustration was created to showcase the use of fullerene structures as 'cages' that can be used as a drug delivery system..
medical illustration of This 3D illustration depicts the epigenetic control of genes available for transcription through the acetylation of histones. Acetylation upregulates gene expression.
medical illustration of This illustration shows the anatomical locations of the major bursae of the shoulder's rotator cuff. It was created as an editorial piece on the subject of inflammation of the bursae.
medical illustration of This illustration shows the etiology of Primary Amoebic Meningoencephalitis. The pathologic amoebae, Naegleria fowleri, invade the brain tissue through the cribriform plate leading to brain hemmorhage and necrosis that is fatal in 98% of cases.
medical illustration of This illustration depicts the dual mode of action of an investigational STING agonist in the treatment of cancer.
medical illustration of This 3D illustration of the limbic system places the focus on the amygdalae, two small pea-shaped structures on either side of the limbic system that play a crucial role in the processing of emotional memory and experiences, including fear and anxiety. Over-activated amygdalae are central to the inappropriate reactions experienced by people who suffer from chronic phobias, obsessions and generalized anxiety.
medical illustration of This highly conceptual 3D illustration symbolizes the devastating effect of amyloidosis on the heart. The hand squeezing the heart is composed of amyloid fibrils. The image was created for the marketing of an investigational amyloidosis drug.
medical illustration of This 3D illustration was created for a book about the neuroanatomical basis of craving.
medical illustration of SHORT-LISTED for the 2016 WORLD ILLUSTRATION AWARDS. (Finalists as yet unannounced.) This 3-dimensional illustration shows the inflammatory environment of the papillary dermis as seen from beneath the epidermis in the early stages of psoriatic plaque development. This image was also used as the stylistic guide for a 3D animated video that our studio, Geras Healthcare Productions, created for a major pharmaceutical drug launch.
medical illustration of This 3D scene features cells in the papillary dermis of the skin that are known to express interleukin-17A (IL-17A), a key proinflammatory molecule involved in the pathogenesis of plaque psoriasis. The cells shown are: fibroblasts, keratinocytes, endothelial cells and a macrophage.This image is derived from a 3D video created by Geras Healthcare Productions for a major pharmaceutical drug launch.
medical illustration of This image featuring strands of DNA was created as one of a series of 3D illustrations for a biotechnology firm.
medical illustration of This view into a synapse was created for a biotechnology firm. It depicts the release of GABA neurotransmitter molecules from presynaptic vesicles, and their binding to the GABAa receptor pentamer in the postsynaptic membrane.
medical illustration of This 3D image shows the brain and three different orientations of the limbic system rendered in a glassy material. It was created for a pharmaceutical client.
medical illustration of This illustration depicts the appearance of Trypanosome brucei protozoa within the bloodstream. T.brucei causes a lethal African illness known as 'sleeping sickness'. The image was created for editorial usage.
medical illustration of This illustration shows a Trypanosome bruceii organism in the blood stream and the immune response to variant surface glycoproteins (VSGs) on the Trypanosome cell membrane. VSGs trigger an immune response via pentameric Immunoglobulin M antibodies. Trypanosome bruceii causes African sleeping sickness.
medical illustration of The illustration shows part 1 of the mode of action of SIRP-alpha Fc in triggering tumor cells to give off an 'eat me' signal to phagocytic macrophages. This painting is the first half of a 120
medical illustration of The illustration shows part 2 of the mode of action of SIRP-alpha Fc: the presentation of tumor antigens to CD8+T cells leading to the proliferation of cytotoxic T cells that are capable of triggering apoptosis of the tumor cells through their release of cytotoxins. This painting is the second half of a 120
medical illustration of This is one of a very large series of illustrations on cells in which the featured cell(s) has been rendered in full color while the background is in B&W halftones.
medical illustration of This 3 dimensional instructional illustration depicts the structures that comprise the blood-brain-barrier. It was created for a biotechnology firm.
medical illustration of This fully 3D illustration displays a network of pyramidal neurons in the brain. The illustration was created for a global pharmaceutical client.
medical illustration of This is a dramatic conceptual image of an ovum and its surrounding corona radiata.
medical illustration of This is a selection of 3 illustrations showing the same subject matter, the heart, depicted in 3 different styles - traditional, conceptual and high tech 3D. I created this montage to demonstrate that biomedical artists have the skills needed to create custom visuals in diverse styles. If the style of art you are seeing is not exactly what you had in mind, but you like the quality of the work, tell us what you are envisioning. Chances are that the look you want is no obstacle.
medical illustration of This is an illustration that was created for a biotechnology firm to show the process of epithelial mesenchymal transition (EMT), whereby tumor cells lose contact inhibition and become mobile, a key first step in metastasis of cancer.
medical illustration of This series of illustrations showing the detailed anatomy of the face were created for the Asian-Pacific Botox market. The facial anatomy shown includes: the skull, blood vessels, nerves, muscles and fat pads
medical illustration of This illustration shows the generation of a molecular signal transduction cascade triggered by the binding of interleukin-17A (IL-17A) to its cell membrane receptor. It also shows the blockade of this cascade by the binding of monoclonal antibodies directed against IL-17A, a key molecule involved in the pathogenesis of several serious inflammatory diseases.
medical illustration of This illustration received the RX Club Award of Excellence, as well as the Society of Los Angeles Illustrators Award of Merit. It depicts the cell interior with a view upwards towards the cell membrane through which cytotoxic signals are penetrating the cell. The illustration is derived from a 3D animated video describing the role of mitochondrial proteins in the induction of apoptosis. Both the illustration and the video were created for a pharmaceutical client.
medical illustration of This illustration received the RX Club Award of Excellence. It depicts a view downwards to the nucleus from inside a cell. The illustration is derived from a 3D animated video describing the role of Bcl-2 family mitochondrial proteins in the induction and inhibition of apoptosis. Both the illustration and the video were created for a global pharmaceutical client.
medical illustration of This 3D illustration depicts the pain associated with the impingement of a cervical nerve root, in this case at C5, due to a vertebral subluxation.
medical illustration of This illustration received the RX Club Award of Excellence. It depicts the Nevo Sirolimus-eluting coronary stent. The image was designed to show the unique cobalt chromium structure and design of the stent, as well as the exceptional flexibilty and conformity of the stent architecture. The drug, Sirolimus, is released from dozens of fully biodegradable polymer wells which dissolve to leave behind a strictly bare metal stent with thin flexible struts.
medical illustration of This 3D illustration shows the early stages in the formation of a plaque-induced blood clot or thrombus. Damage to the endothelial cells lining the blood vessel lumen exposes a variety of platelet-activating factors, including collagen fibres, to the circulating blood. Platelets coming into contact with these factors adhere to the plaque surface and undergo dramatic morphologic changes. This is the first step in the initiation of a complex coagulation cascade leading to thrombus formation.
medical illustration of This 3D image was displayed in a pharmaceutical exhibit at a conference focused on lysosomal diseases. It features the molecule, alpha-galactosidase A, which is deficient in Fabry disease. Fabry disease is a rare genetic lysosomal storage disorder.
medical illustration of This diagrammatic illustration depicts the cellular and molecular pathway involved in the pathogenesis of Gaucher Disease, an inherited metabolic disorder that leads to the accumulation of the lipid glucocerebroside in cells and certain organs. Gaucher disease causes the deficiency of an enzyme, glucocerebrosidase, that normally breaks down and recycles this lipid.
medical illustration of This is a conceptual illustration depicting VEGF (vascular endothelial growth factor) molecules in the blood stream.
medical illustration of This advertising illustration depicts the normal branching of the bronchioles in the lungs and features a magnified view of a bronchiolar cross-section, as well as of alveoli and their surrounding blood vessels. It was printed as a poster for a global pharmaceutical firm.
medical illustration of This illustration was created for a global pharmaceutical company as part of a series of images on rheumatoid arthritis. The illustration shows the progressive damage to the articular cartilage and bone of the head of the femur.
medical illustration of The illustration shows the normal stages in the birth of a child. It was created as a patient education series for Lamaze International.
medical illustration of This illustration is one of a series of illustrations that was created for a firm specializing in dermatology products. The series depicts the formation of Prosomes, a patented treatment delivery system that is able to deliver kinetin and zeatin molecules deep into the skin. Geras Healthcare Productions also created a 3D animated video describing this technology.
medical illustration of This painting received an Rx Club Award of Excellence. It was designed for a manufacturing firm. It demonstrates the effect of photodynamic therapy on the vasculature of prostate tumours. Damage to the vessels feeding the tumours results in cancer cell death and tumour shrinkage.
medical illustration of This editorial illustration depicts the interior of the right ventricle of the heart. It also shows the right bundle branch of the heart's conduction system including the small fibres that feed the papillary muscles.
medical illustration of This is an editorial illustration depicting the exterior of a normal eye. It was paired with a second illustration showing the appearance of an eye with conjuctivitis.
medical illustration of This pharmaceutical poster was published as a limited, signed edition and was used as a promotional give-away. It describes the pathogenesis of glaucoma.
medical illustration of This dramatic 3D illustration features a bovine egg cell or ovum and approaching spermatazoa. It was created for a client specializing in the discovery, development and manufacturing of animal health products worldwide. The image was designed as an exhibit mural for a veterinary conference. A horizontal version of this image was used as a 60 ft. banner spanning the width of the exhibit booth.
medical illustration of This is a conceptual illustration designed to represent the tragically common inability of cancer therapies to prevent the metastasis and progression of cancer.
medical illustration of This illustration shows the correct positioning of the new Supreme Laryngeal Mask Airway. It was created for the device manufacturer.
medical illustration of This illustration was created as an advertising poster for Omnaris nasal spray, a drug used in the treatment of nasal allergies and hay fever. The client wished to show the distribution of the drug particles within the upper respiratory system.
medical illustration of This is a 3D model I created for use as a logo by our studio, Geras Healthcare Productions. It has been rendered in 2 different styles; naturalistic and in a glass-like material. The concept references the saying 'as alike as three peas in a pod
medical illustration of This pharmaceutical illustration shows the gross anatomical changes to the brain tissue as a result of brain shrinkage.
medical illustration of The illustration compares drug dispersal patterns associated with the use of injection versus transduction delivery methods. It was created for the transduction device manufacturer. The device is designed for use in the treatment of diabetes.
medical illustration of This was created as a patient education poster for a pharmaceutical client. It illustrates the major features of the respiratory system. It also includes spot illustrations depicting sinusitis, pneumonia and bronchitis.
medical illustration of This collection of images was created for a patient education poster, The Genitourinary System, published by a pharmaceutical firm.
medical illustration of This is a montage of selected anatomical illustrations dealing with skeletal, bone and joint structures. The individual spots have been used in a variety of print materials including patient education posters, flip charts and brochures.
medical illustration of This is a patient education illustration showing the basic anatomy of the kidney, as well as enlarged views of a kidney pyramid and nephron.
medical illustration of This medical illustration depicts the different types of fibroids that may be found in the uterus. It also shows a section though the endometrium, and the pituitary gland within a ghosted brain. It was created for an advertising agency.
medical illustration of This series of anatomical illustrations was created for a pharmaceutical firm. They were part of a series of 20 illustrations relating to prostate gland health. This selection of images shows both the normal male reproductive/urinary anatomy as well as urinary retention caused by benign prostatic hypertrophy.
medical illustration of This is a small selection of traditional anatomical illustrations that were created for a variety of print materials. Shown are: the liver, the duodenum with pancreas, and the stomach.
medical illustration of This is one of a series of anatomical paintings of musculoskeletal subjects created for a pharmaceutical flip chart. The illustration shows the musculature of the knee.
medical illustration of This is one of a series of anatomical paintings of musculoskeletal subjects created for a pharmaceutical flip chart. The illustration shows the musculature of the foot.
medical illustration of This painting is one of 50 illustrations created for the book Dermatology: A Medical Artist's Interpretation, written and illustrated by Audra Geras. The book won the Association of Medical Illustrators Award of Excellence for Best Illustrated Atlas. The illustration depicts the normal structure of the pilar apparatus, which includes: hair follicle, eccrine sweat gland, and erector pili muscle.

Profile

Audra Geras is an internationally recognized, multiple award-winning biomedical artist with degrees in both biology and visual biocommunications from the University of Toronto. She heads Geras Healthcare Productions, a boutique visual biomedical communications studio specializing in the creation of innovative custom illustration and 3D animated videos. Audra is a visual storyteller dedicated to finding successful solutions to medical and scientific communication challenges with clear, accurate and beautiful visuals.

Style/Techniques

Animation, Airbrush, Color, Design, Information Graphics, 3D, Apps/Mobile, Models, Microscopy

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Botany, Cardiac Surgery / Cardiology, Cell biology / Histology, Dentistry, Dermatology, Disease Management, Emergency Medicine, Endocrinology / Metabolic, General Medicine, General Surgery, Genetics, Maternal / Child, Medical Devices, Molecular Biology, Natural History, Natural Science / Nature, Neuroscience, Neurosurgery, Obstetrics / Gynecology, Ophthalmology, Orthopaedics, Pediatrics, Pharmacology, Physical Therapy, Reconstructive Surgery, Portraits, Reproductive Biology, Respiratory, Thoracic Surgery, Transplantation Surgery, Urology, Vascular Surgery, Veterinary Medicine, Virology, Injuries, Oncology, Mechanism of Action (MOA), Health & Wellness, Hemophilia, Pathology, Sports Medicine