Audra Geras

The Weber Group

Perforins and Granzymes 

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Synthesis and Transfer of MHC Class 1 Molecules

medical illustration of This image is one from a series of immunology-related illustrations. It depicts the release of perforin and granzyme molecules from vesicles in a cytotoxic CD8+ T cell, the assembly of the perforin molecules into pores in the cell membrane of a tumor cell, which then allows the entry of the granzyme molecules. This results in the killing of the tumor cell (bottom right).
Next medical illustration of This is image is one from a series of immunology-related illustrations. It provides a close-up view of the presentation of tumor antigen by an MHC Class 1 molecule to a T cell receptor (TCR). This results in the activation of the T cell.

Antigen Presentation and T Cell Activation

This image is one from a series of immunology-related illustrations. It depicts the release of perforin and granzyme molecules from vesicles in a cytotoxic CD8+ T cell, the assembly of the perforin molecules into pores in the cell membrane of a tumor cell, which then allows the entry of the granzyme molecules. This results in the killing of the tumor cell (bottom right).

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