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Jackie Heda

Mechanism 1 Anifrolumab binds IFNAR1  

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medical illustration of Mechanism 1:  Anifrolumab, a monoclonal antibody, binds IFNAR1 and blocks the type I IFN from binding IFNAR1 preventing the formation of a functional IFNAR1/2 signaling complex.
Next medical illustration of Anifrolumab is shown to induce internalization of IFNAR1 thereby reducing availability for IFNAR1/2 assembly.

Normal Type I Interferon Signaling Pathway

Mechanism 1: Anifrolumab, a monoclonal antibody, binds IFNAR1 and blocks the type I IFN from binding IFNAR1 preventing the formation of a functional IFNAR1/2 signaling complex.

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© Jackie Heda