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Sumitomo Dainippon Pharma Oncology

Napabucasin Chemotherapeutics

Jackie Heda

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Chemotherapeutics research. ROS, free radical. Containing oxygen, it is an unstable molecule that easily reacts with other molecules in a cell. A build up of reactive oxygen species in cells may cause damage to DNA, RNA, and proteins, and may cause cell death. Napabucasin is a STAT3 inhibitor that blocks stem cell activity. As a cancer therapy Napabucasin causes increased reactive oxygen species (ROS) which results in cancer cell death.

2021

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medical illustration of Primary amoebic meningoencephalitis (PAM) is a rare and severe disease caused by a single-celled amoeba called Naegleria fowleri, which infects individuals when swimming in fresh water streams, lakes, and ponds. The amoeba travels via the nasal passages, comes in contact with nerve endings causing inflammation and destruction of the brain and the linings of the brain. Amoebic meningoencephalitis is usually fatal.
medical illustration of Heart failure can be classified as left-sided or right-sided, depending on whether systemic or pulmonary circulation is the cause, or which chambers are affected. Left-sided heart failure typically leads to right-sided heart failure. The term ‘heart failure’ usually refers to left-sided heart failure. Left ventricle, reduced ejection fraction, LVEF, diastolic, systolic, blood, pulmonary veins, biventricular
medical illustration of PROTAC stands for proteolysis-targeting chimera. A PROTAC is composed of two or three molecules and is used to induce targeted proteolysis. The use of proteolysis-targeting chimeras (PROTACs) is a new technology utilizing a intracellular ubiquitin-proteasome for removal of unwanted proteins. It is valuable in cancer therapies. Bifunctional PROTAC molecule, covalently linked ligand of an E3 ubiquitin ligase (E3), ligand protein of interest (POI), targeted cancer therapy
medical illustration of PROTAC stands for proteolysis-targeting chimera. A PROTAC is composed of two or three molecules and is used to induce targeted proteolysis. The use of proteolysis-targeting chimeras (PROTACs) is a new technology utilizing a intracellular ubiquitin-proteasome for the removal of unwanted proteins, and is useful in cancer therapies.
medical illustration of Alzheimer's and Lewy Body Dementia are two brain conditions that exhibit loss of neurological function, but exhibit different pathologies.
medical illustration of Alvocidib is an investigational, intravenously administered. small molecule cyclin-dependent kinase (CDK9) inhibitor. Inhibiting CDK9 is thought to down regulate the transcription of target genes, including myeloid cell leukemia 1 (MCL-1), reducing leukemic blast vitality in MCL-1-dependent hematologic malignancies. #alvocidib #cancer therapy #molecules #apoptosis #leukemia
medical illustration of DSP-7888 is an investigational cancer vaccine containing two peptides that induce WT1-specific cytotoxic T lymphocytes and helper cells to attack WT1-expressing cancerous cells found in various types of hematologic malignancies and solid tumors. Researchers have found that adding helper T-cell-inducing peptides, improved outcomes may be achieved compared with a treatment regimen that induced only WT1-CTL's. #cancer therapy DSP-7888 #cancer cell apotheosis #T- cell #cytotoxic lymphoma
medical illustration of TP-0184 is an investigational inhibitor of activin A receptor type 1 (ACVR1) kinase, also known as ALK2. Inhibiting ACVR1 may have anti tumor effects in several types, decrease hepcidin expression, increase bioavailable iron, and restore levels of hemoglobin. #cancer therapy #anti-tumor effects #hepcidin #hemoglobin levels #ACVR
medical illustration of TP-3654 #cancer therapy
medical illustration of TP-1454 is an investigational oral pyruvate kinase (PKM2) activator. This activation is thought to starve the cells of important molecular building blocks, inhibiting tumor cell production, and enhancing anti-tumor response. #cancer therapy #trimer #PKM2 activator #tumor cell #anti-tumor
medical illustration of Napabucasin is an investigational product that increases reactive oxygen species in an environment of proliferating cancer cells, causing cancer cell death. #cancer therapy # cell signaling #ROS #cancer cell death #NQO1 #cancer cell survival #redox balance
medical illustration of Multiple myeloma is a cancer of the bone that forms in a type of white blood cell called a plasma cell in the marrow. Healthy plasma cells help you fight infections by making antibodies that recognize and attack germs. In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells compromising immunity.
medical illustration of Eosinophilic inflammation involves eosinophil recruitment and activation and enables eosinophils to infiltrate patients' tissue to drive and worsen disease and in this case, respiratory. This diagram shows the cells involved and most importantly the first step in the process: secretion of Thymic Stromal Lithopoeitin (TSLP) by epithelial cells in response to an irritant.
medical illustration of Axonal polyneuropathy involves sensory and and motor peripheral nerves and affects function in both. There can as a result be loss of feeling and muscle function.
medical illustration of Crohn's disease is an inflammatory bowel disease affecting the large intestine and small intestine.
medical illustration of Avatrombopag, an investigational thrombopoietin-receptor agonist, is effective in persistent and chronic immune thrombocytopenia and stimulates platelet production.
medical illustration of Corticosteroids in inflammation: Mode of action illustration showing the second messenger mechanism of water soluble hormones.
medical illustration of Color, Information Graphics, Advertising / Marketing, Education, Allergy / Immunology, Dermatology
medical illustration of Age related degeneration of disks leads to dehydration and shrinking of disks and development of osteoarthritis.
medical illustration of Plaques commonly form in arteries and cause no symptoms until they impede blood flow.
medical illustration of Lice are treated with this pharmaceutical product that interferes with the nervous system of the louse, specifically normal nerve transmission, destroying the parasite.
medical illustration of Normally the lower esophageal sphincter (LES) closes after food passes from the esophagus to the stomach. When the LES is weakened, it fails to close properly and food and gastric contents reflux into the esophagus as shown.
medical illustration of
medical illustration of Mutations of the CFTR gene affect chloride ion channel function. This leads to dysregulation of epithelial fluid transport in the lung, and other organs and leads to cystic fibrosis.
medical illustration of Color, Information Graphics, Education, Patient Education, Health & Wellness
medical illustration of Multiple myeloma is a cancer of the white blood cells, specifically the plasma cells. Cancerous plasma cells proliferate in the bone marrow compromising immune response and the body's ability to fight infection
medical illustration of Mechanism 1: Anifrolumab, a monoclonal antibody, binds IFNAR1 and blocks the type I IFN from binding IFNAR1 preventing the formation of a functional IFNAR1/2 signaling complex.
medical illustration of Mode of action illustration showing the molecular factors leading to chronic psoriasis.
medical illustration of Cause of ALS is instability of microtubules of neuron which results in impaired nerve conduction to voluntary muscles.
medical illustration of Normal anatomy of the ear and three conditions involving the eardrum in otoscopic and frontal views
medical illustration of Role of COX (cyclooxygenase) 1 and 2 in inflammation has implications for the kidney and NSAIDs.
medical illustration of The blood-brain barrier consists of several critical components as illustrated and it exists as a highly selective semi-permeable barrier between the body's circulating blood and the brain.
medical illustration of An illustration of the normal dentition. The teeth are named and numbered, and a version of this illustration designating incisor, canine, and molar nomenclature is available
medical illustration of Chronic Obstructive Pulmonary Disease (COPD) manifests itself as a combination of chronic bronchitis and emphysema.
medical illustration of Education, Museum / Zoo, Publishing, Stock, Anatomy, Biology, Zoology
medical illustration of Color enhancement of open reduction and internal fixation of the left clavicle
medical illustration of The normal aorta is very elastic, and flexible as needed to adapt to blood flow. But some conditions, such as high blood pressure, atherosclerosis, and wear and tear due to age weaken the artery walls causing the wall to bulge outward.
medical illustration of Advertising / Marketing, Education, Disease Management, Gastroenterology, Molecular Biology, Pharmacology
medical illustration of A silicon hydrogel lens and the technology allowing for 80% water on the outer surface where it comes into contact with the eye.
medical illustration of A liver biopsy is as an outpatient procedure. A needle is inserted between two of the right lower ribs to remove a sample of liver tissue which is sent to a laboratory and for microscopic evaluation.
medical illustration of Narrowing of the esophagus may develop as a result of frequent heartburn and the formation of scar tissue. This impairs swallowing. Esophageal dilation involves inserting an endoscope in the esophagus and inflating a balloon dilator to stretch the lumen.
medical illustration of This is the first image on immunity in a series of patient education illustrations for autoimmune encephalitis.
medical illustration of This is the second in a autoimmune encephalitis series showing the blood brain barrier.
medical illustration of This image shows how the blood brain barrier may be transgressed and the brain can be under attack in autoimmune encephalitis.
medical illustration of Color, Information Graphics, Advertising / Marketing, Editorial, Education, Patient Education, Gastroenterology, Oncology
medical illustration of Brimonidine is a drug used to treat open-angle glaucoma or ocular hypertension. Illustration shows its molecular mode of action in ciliary epithelium. Essentially the synthesis of aqueous humor is decreased, and the amount of aqueous humor that drains from the eye through uveoscleral outflow is increased.
medical illustration of The features of inflammation and typical cellular and complement presence in Irritable Bowel Syndrome is contrasted with normal mucosa.
medical illustration of A section through a wart and a microscopic view below the the skin's surface.
medical illustration of A tooth is extracted and during the same procedure bone graft is put in its place as bone and gingiva heal.
medical illustration of A series of images showing the basic steps in a dental implant procedure.
medical illustration of In wet AMD the oxygen supply to the macula is disrupted and new, abnormal blood vessels form. These begin to grow through the breaks of the membrane behind the retina towards the macula, often raising the retina.
medical illustration of Advertising / Marketing, Editorial, Education, Patient Education, Dentistry, Medical Devices, Oncology, Mechanism of Action (MOA)
medical illustration of Advertising / Marketing, Editorial, Education, Patient Education, Publishing, Stock, Dentistry, Medical Devices, Oncology, Mechanism of Action (MOA)
medical illustration of An endoscopy is a nonsurgical procedure used to examine the digestive tract. An endoscope is a a flexible tube with a light and camera attached to it, allowing your doctor view pictures of your digestive tract on a color TV monitor.
medical illustration of Brimonidine is a drug used to treat open-angle glaucoma or ocular hypertension. Illustration shows its molecular mode of action. Essentially the synthesis of aqueous humor is decreased, and the amount of aqueous humor that drains from the eye through uveoscleral outflow is increased.
medical illustration of First three steps in periodontal procedure called Guided Bone Regeneration (GBR) involves resection of gingiva, perforation of bone, and placement of bone graft material.
medical illustration of A series of three images complete the GBR procedure.
medical illustration of An illustration showing the mode of action of the disease process in gout.
medical illustration of Advertising / Marketing, Patient Education, Stock, Gastroenterology, Pharmacology
medical illustration of Advertising / Marketing, Editorial, Education, Stock, Cardiac Surgery / Cardiology, Disease Management, Medical Devices
medical illustration of This is a simplified illustration of rheumatoid arthritis showing the normal joint on the left and the arthritic joint on the right.
medical illustration of Editorial, Patient Education, Stock, Dentistry
medical illustration of Advertising / Marketing, Editorial, Education, Patient Education, Stock, Allergy / Immunology, Dermatology, General Medicine
medical illustration of Advertising / Marketing, Editorial, Patient Education, Dentistry, Medical Devices, Mechanism of Action (MOA)
medical illustration of Editorial, Patient Education, Dentistry, Medical Devices, Mechanism of Action (MOA)
medical illustration of In the final part of this periodontal procedure bone graft is covered with a membrane, the incision is closed with sutures, and after a period of healing an implant can be placed. A crown is the final step.
medical illustration of Color, Editorial, Medical Malpractice, Cell biology / Histology, General Medicine, General Surgery, Medical Devices
medical illustration of Color, Editorial, Education, Publishing, Stock, Allergy / Immunology, Botany, Dermatology, General Medicine, Pharmacology
medical illustration of Animation, Color, Advertising / Marketing, Editorial, Education, Patient Education, Stock, Allergy / Immunology, Disease Management, Neuroscience
medical illustration of Color, Advertising / Marketing, Editorial, Education, Patient Education, Stock, Allergy / Immunology, Emergency Medicine, Pediatrics, Pharmacology, Respiratory
medical illustration of Advertising / Marketing, Editorial, Education, Stock, Web, Allergy / Immunology, General Medicine, Respiratory
medical illustration of Color, Editorial, Education, Cardiac Surgery / Cardiology, Molecular Biology, Pharmacology, Respiratory
medical illustration of Advertising / Marketing, Publishing, Cardiac Surgery / Cardiology

Profile

Jackie Heda Certified Medical Illustrator with a postgraduate degree in Art as Applied to Medicine, University of Toronto. • Services include creative direction, 2D and 3D biomedical illustration, storyboard development, 2D and 3D animation, and medical-legal illustration. • Clients include pharmaceutical and biotech companies, advertising agencies, design firms, and the medical and legal professions.

Style/Techniques

Animation, Airbrush, Color, Information Graphics, 3D, Live Action Video

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Botany, Cardiac Surgery / Cardiology, Cell biology / Histology, Dentistry, Dermatology, Disease Management, Emergency Medicine, Endocrinology / Metabolic, Gastroenterology, General Medicine, General Surgery, Genetics, Medical Devices, Molecular Biology, Neuroscience, Ophthalmology, Orthopaedics, Pediatrics, Pharmacology, Physical Therapy, Respiratory, Thoracic Surgery, Vascular Surgery, Virology, Zoology, Injuries, Legal Exhibits, Oncology, Mechanism of Action (MOA), Health & Wellness, Sports Medicine