Cold Agglutinin Disease 

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medical illustration of Image shows Cold agglutinin disease (CAD) – a rare autoimmune hemolytic anemia driven by the production of cold agglutinins (CA). Despite published guidelines, there remains variability in the use and ordering of CA studies. Screening first for a C3d-positive DAT could help significantly reduce the need for more labor-intensive, specialized tests.
Next medical illustration of An immune checkpoint inhibitor (a monoclonal antibody) is shown activating a T cell (blue) to attack a cancer cell (green). While checkpoint inhibitors represent an important class of anticancer agent, their use sometimes results in immune cells damaging normal tissue.

Immune Cells and Checkpoint Inhibitors

Image shows Cold agglutinin disease (CAD) – a rare autoimmune hemolytic anemia driven by the production of cold agglutinins (CA). Despite published guidelines, there remains variability in the use and ordering of CA studies. Screening first for a C3d-positive DAT could help significantly reduce the need for more labor-intensive, specialized tests.

Keywords: 3D, Editorial, Biotechnology, Cell biology / Histology, Endocrinology / Metabolic, General Medicine, Vascular Surgery

© Linda Nye