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Next medical illustration of Image shows Cold agglutinin disease (CAD) – a rare autoimmune hemolytic anemia driven by the production of cold agglutinins (CA). Despite published guidelines, there remains variability in the use and ordering of CA studies. Screening first for a C3d-positive DAT could help significantly reduce the need for more labor-intensive, specialized tests.

Cold Agglutinin Disease

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© Linda Nye