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Alexander & Turner Inc. Studio

AMI #20

Page 60

Alexander & Turner Inc. Studio

AMI #20

Page 61

Alexander & Turner Inc. Studio

AMI #20

Page 62

Alexander & Turner Inc. Studio

AMI #20

Page 63

Alexander & Turner Inc. Studio

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Alexander & Turner Inc. Studio

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Alexander & Turner Inc. Studio

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Alexander & Turner Inc. Studio

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Alexander & Turner Inc. Studio

Represented by

Shannon Associates
333 West 57th Street, Suite 809
New York, NY 10019
United States

medical illustration of Contemplating the respiratory ravages of severe acute respiratory syndrome from SARS-CoV-2, lung epithelial cells are portrayed as a planetary landscape immersed in a cyanotic, watery underworld. Viral budding from the plasma membrane of lung epithelial cells enables coronaviruses to exit the host cell after infection and replication. This initiates a cytokine storm, a sudden over-response all at once from an immune system gone awry, producing an inflammatory response flaring out of control.
medical illustration of A Cytotoxic Killer TCell induces a cancer cell to undergo programmed cell death known as apoptosis. These Killer TCells are programmed to seek out, attach themselves and kill cancer cells, usually using chemicals. They recognize a specific site (antigen) on the surface of cancer cells and bind to it. The Killer T Cell then eliminates the cancer cell by releasing a protein that forms pores in the cancer cell's membrane and specifically induces apoptosis.
medical illustration of Disease caused by decreased platelet production can be augmented by platelet-stimulating agents that interact with the transmembrane domains of the thrombopoietin receptors, thereby complementing native thrombopoietin that binds with the extracellular domains.
medical illustration of Fantasy dramatization of gastrointestinal microbiota flowering, fertilized by the churning gastric environment. Flowering is depicted by petals of Bacteroidetes, Bifidobacteriam, and Enterococcus faecalis, pistils of Lactobacillus and stamens of Enterococcus faecalis perched on E. coli stalks. The flower emerges on Clostridium difficile stalks. Bacillus cereus, in their arthomitus stage, attach by fibers to the intestinal epithelium, grow filamentously, and sporulate from their distal ends.
medical illustration of Stem cells emerge from a mysterious source to supply ongoing life support to a bionic skull. Stem cells, in life, are undifferentiated cells that can turn into specific cells, as the body needs them. Here they are depicted as transforming into differentiated hybrid living/bionic cells capable of rebuilding the bionic skull.
medical illustration of PD-1 & PD-2 (Programmed Death) protein receptors on tumor cells down regulates the immune system and promotes self-tolerance by suppressing TCell anti-inflammatory activity. When this protein is blocked, the “brakes” on the immune system are released and the ability of T Cells to kill cancer cells is increased.
medical illustration of Atypical Hemolytic Uremic Syndrome (aHUS) manifests by chronic uncontrolled complement activation leading to the continuous activation of platelets and endothelial cells. The resulting thrombi cause thrombotic microangiopathy which may result in sudden fatal thrombotic complications or in the progressive failure of vital organs, including the kidney, heart, and brain. For Alexion Pharmaceuticals.
medical illustration of The anatomical site of aqueous humour production in healthy ciliary processes epithelium and the aqueous humor drainage through healthy trabecular meshwork in the anterior chamber angle.
medical illustration of The neurovascular unit for Remedy Pharmaceuticals investor relations. Remedy’s drug candidate reduces brain swelling and hemorrhage following traumatic injury. The brain microvessels, astrocytes, pericytes, neurons, microglia and the extracellular matrix form functional neurovascular units to maintain a precisely regulated microenvironment for reliable neuronal signaling.
medical illustration of Bone marrow is the site of hematopoiesis – the formation of hematopoietic stem cells which give rise to the three classes of white blood cells, red blood cells, and platelets.
medical illustration of The diabetic glomerulus exhibits glomerular hypertrophy and mesangial matrix expansion due to the increase of intra- and extracellular proteins from advanced glycation end-products, increased basement membrane thickness, and podocyte apoptosis.
medical illustration of COX-2 selective NSAIDs were developed to maintain analgesia efficacy while minimizing the side effects associated with COX-1 inhibition. The cyclooxygenase enzyme is anchored to the endoplasmic reticulum membrane. Above it, released prostaglandin hormones soar into the cell. The COX-2 selective NSAID is blocked from the channel of access for COX-1, but gains entry at COX-2 site, and thereby inhibits the active site for pain prostaglandin creation.
medical illustration of Tivantinib™ is designed to block the activity of c-MET, a molecule that plays multiple key roles in human cancer including cancer cell growth,survival, angiogenesis, invasion and metastasis in nsNSCLC (non squamous Non-Small Cell Lung Cancer).
medical illustration of Radiation Therapy (SBRT) has yielded promising results for patients who were mostly medically inoperable. The good results have led some institutions to treat medically operable patients with SBRT. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of Precisely aimed ionizing radiation beams coming from different directions meet at a specific point to deliver radiation treatment to the tumor location. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of DNA damage can occur naturally from metabolic or hydrolytic processes or be induced by outside influences, and results in an alteration of the chemical structure of DNA, such as a break in a strand of DNA, a base missing from the backbone of DNA, or a chemically changed base. For Varian Surgical Sciences.
medical illustration of RapidArc® delivers a precisely sculpted 3D dose distribution in a single 360-degree rotation of the linear accelerator gantry through an algorithm that simultaneously changes rotation speed, shape of the treatment aperture and delivery dose rate. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of An acoustic neuroma on the nerve sheath of the vestibular portion of the 8th cranial nerve is an operatively challenging tumor ideally suited for stereotactic radiosurgery, a volumetric modulated arc technique that allows for highly conformal, intensity-modulated dose distributions to be delivered with a single 358° rotation of the gantry of the linear accelerator. For Varian Surgical Sciences.
medical illustration of An intra-cranial meningioma arising from the cavernous sinus at the base of the brain is an operatively challenging tumor ideally suited for stereotactic radiosurgery, a volumetric modulated arc technique that allows for highly conformal, intensity-modulated dose distributions to be delivered with a single 360° rotation of the gantry of the linear accelerator. For Varian Surgical Sciences.
medical illustration of Renowned photographer Gerald Förster photographed models holding empty frames. Matching the silhouettes of the framed limbs, Cynthia created illustrations simulating x-rayed bones exhibiting psoriatic arthritis. Global Advertising Campaign for Enbrel™ Wyeth.
medical illustration of Renowned photographer Gerald Förster photographed models holding empty frames. Matching the silhouettes of the framed limbs, Cynthia created illustrations simulating x-rayed bones exhibiting psoriatic arthritis. Global Advertising Campaign for Enbrel™ Wyeth.
medical illustration of The sixteen pathogens indicated for the broad spectrum antibiotic INVANZ™ for a global launch campaign by Merck Pharmaceuticals: Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, Streptococcus agalactiae, Porphyromonas asaccharolytica, Prevotella bivia and Biophilia wadsworthia.
medical illustration of The sixteen pathogens indicated for the broad spectrum antibiotic INVANZ™ for a global launch campaign by Merck Pharmaceuticals: Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, Streptococcus agalactiae, Porphyromonas asaccharolytica, Prevotella bivia and Biophilia wadsworthia.
medical illustration of Gastroesophageal Reflux Disease is often mistaken for occasional heartburn but is a serious digestive disorder. The lower esophageal sphincter opens more often that it should, and stomach acid travels up into the esophagus where it can erode the esophageal lining. A layer of mucus protects the duodenum from harsh stomach acid, but H. pylori bacteria damage the protective lining, leading to an ulcer.
medical illustration of The brain is the seat of intelligence, interpreter of the senses, initiator of body movement, and controller of behavior and the source of all the qualities that define our humanity. For Alkermes Biopharmaceuticals.
medical illustration of Peripheral tumor locations are treated with three-dimensional conformal radiation therapy using computer technology to more precisely target the tumor with radiation beams by using width, height, and depth measurements. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of Precisely aimed ionizing radiation beams coming from different directions meet at a specific point to deliver radiation treatment to the tumor location. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of The Calypso Beacon® GPS system allows real-time tracking of tumor position and motion with sub-millimeter accuracy by utilizing miniaturized, non-ionizing implanted electromagnetic transponders called beacons. The beacons activate through harmless electromagnetic waves to communicate with the Calypso GPS system, assuring radiation is delivered precisely to the prescribed target by continuously and accurately tracking real-time tumor position and motion. For Varian Medical Systems.
medical illustration of A collection of healthy eyes; hazel eyes for Allergan Optive™ dry eye lubricant eye drops and blue eye for Johnson & Johnson’s Vistacon Accuvue contact lenses.
medical illustration of The Hydrus™ Microstent is designed to treat the high intraocular pressure that occurs in patients with primary open-angle glaucoma because the eye’s fluid path becomes blocked. The scaffolded stent is designed to be inserted into Schlemm’s canal to gently dilate the channel and allow blocked fluid to flow more freely and alleviate high intraocular pressure.
medical illustration of RapidArc™ delivers a precisely sculpted 3D dose distribution in a single 360-degree rotation of the linear accelerator gantry through an algorithm that simultaneously changes rotation speed, shape of the treatment aperture and delivery dose rate. Limited Edition Print for Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of Temporary radioactive seed loadings are introduced into the prostate gland by carefully placed needles enabling the dose cloud to conform the radiation dose to the size and shape of the tumor target. The technique takes advantage of the inverse square law (the intensity of radiation is reduced by the square of the distance from the source) since the sources are placed in the target area, limiting side effects and sparing surrounding anatomy. For Varian Surgical Sciences.
medical illustration of RapidArc™ delivers a precisely sculpted 3D dose distribution in a single 360-degree rotation of the linear accelerator gantry through an algorithm that simultaneously changes rotation speed, shape of the treatment aperture and delivery dose rate. For Varian Surgical Sciences, exhibit panel, print and event collateral.
medical illustration of IMRT (Intensity Modulated Radiation Therapy) uses 3-D scans of the target area and surrounding tissue to guide the radiation beams to the tumor or the seroma (post-surgical site) from many different angles. For breast cancer, radiation beams are projected at tangent angles in order to skim the chest wall, allowing for a maximum dose of radiation to be delivered to the target while minimizing exposure to the heart and lungs. For Varian Surgical Sciences.
medical illustration of Mast cells degranulate and release histamine and cytokines when triggered by inhaled irritants, exercise, cold air, smoke or dust, provoking the inflammatory response of hyper-responsive airways to constrict, inflame and fill with excessive mucus.
medical illustration of The exudative stage of ARDS is an immune response designed to reduce lung injury in the case of severe systemic inflammation but is so extreme that it damages the endothelium and epithelium, resulting in edema and pulmonary injury.
medical illustration of When a person with celiac disease ingest gluten the immune system reacts by damaging the villi in the lining of the intestine resulting in villous atrophy, crypt hyperplasia and increased intraepithelial lymphocytes.
medical illustration of The human cardiovascular system is the network of arteries that transport oxygenated blood from the heart to deliver oxygen and nutrients to the body's cells and return the deoxygenated blood back to the heart via the network of veins. Chapter Opener for The Ultimate Bodypedia: An Amazing Inside-Out Tour of the Human Body, National Geographic Society.
medical illustration of Aristotle believed the rational soul resided in the heart, rather than the brain. Cover for AstraZeneca Annual Report.
medical illustration of BioVentrix™ surgical device implants anchors in the heart wall and subsequently plicates myocardium to exclude scarred, non-contractile left ventricle myocardium.
medical illustration of Showcasing gluteal anatomy including the gluteus maximus, gluteus medius, and gluteus minimus muscles, the sacrum, ilium and femur bones and the sciatic nerve. Bookcover, The Art of Gluteal Sculpting, Constantino G. Mendieta MD, FACS.
medical illustration of Accidental poisoning mostly occurs in children under the age of three, especially boys.
medical illustration of The lymphatic drainage of breast originates from the breast lobules and flows into a sub-areolar plexus called Sappey’s plexus and then takes place through three main routes: axillary or lateral pathway, internal mammary pathway and the retromammary pathway. For GlaxoSmithKline.
medical illustration of Showcasing the posterior leg muscles, including the Gluteals, Biceps femoris, Vastus lateralis, Semimembranosus, Semitendinosus and Adductor magnus.
medical illustration of Showcasing the pectoralis major muscle and its insertions: the clavicular head that flexes the arm at the shoulder and the sternocostal head that extends the arm at the shoulder from a flexed position.
medical illustration of Stalled-healing venous leg ulcer and stalled-healing diabetic foot ulcer. For Apligraf, Health4Brands.
medical illustration of Baseline before response to etanercept treatment by severe plaque psoriasis patients with suboptimal response to topical treatments. For Enbrel™ Dermatology Patient Galleries, Amgen / Wyeth Pharmaceuticals.
medical illustration of 12 week response to etanercept treatment by severe plaque psoriasis patients with suboptimal response to topical treatments. For Enbrel™ Dermatology Patient Galleries, Amgen / Wyeth Pharmaceuticals.
medical illustration of 24 week response to etanercept treatment by severe plaque psoriasis patients with suboptimal response to topical treatments. For Enbrel™ Dermatology Patient Galleries, Amgen / Wyeth Pharmaceuticals.
medical illustration of Uterus, ovaries, ovulating ovary, and ovum traveling through the fallopian tube accompanied by its nourishing follicular cells.
medical illustration of A macrophage encounters the pathogen Klebsiella pneumonia bacteria, and ingests, processes and displays antigens on its surface. A T-Helper cell recognizes the antigen, causing it to release chemical messages called cytokines to recruit cytotoxic T-cells and B-cells, initiating the immune response. Chapter Opener for The Ultimate Bodypedia: An Amazing Inside-Out Tour of the Human Body, National Geographic Society.
medical illustration of Thrombopoietin (TPO) is a protein produced primarily in the liver that controls how many platelets are made. In people with chronic Idiopathic Thrombocytopenia (ITP) there usually isn't enough TPO (orange) reaching the bone marrow when platelet levels get low. TPO Receptor Agonist (green) works by stimulating megakaryocytes and their precursors in the bone marrow, leading to proliferation and differentiation of these cells.
medical illustration of APC Dendritic Cells play a critical role initiating tumor destruction by activating T Cells. Tumor cells produce antigens that are captured by antigen presenting cells (APCs). The APCs that activate T-Cells are usually dendritic cells because T Cells cannot recognize or respond to free or soluble antigens but they can recognize and respond to antigens that have been processed and presented by APC dendritic cells.
medical illustration of A bispecific monoclonal antibody is engineered to simultaneously bind to a cytotoxic cell and a targeted tumor cell.
medical illustration of Unique cell proteins are distributed across the cell surface to accept communication signals from extracellular signaling ligands like hormones, neurotransmitters, cell recognition molecules and growth factors.
medical illustration of Protein-ligand binding activates the lipid membrane surface protein to trigger intracellular signaling pathways. CD38 is a surface protein for cell activation found on immune cells, and its deficiency is linked to impaired immune responses and metabolic disturbances.
medical illustration of Receptor Tyrosine Kinase (RTKs) are high-affinity cell surface receptors for cell maintenance but also initiate the development of many cancers. RTK occurs when a ligand attaches to the HER 2 receptor and then connects to the HER 3 receptor, signaling intracellular proteins to initiate cell division. Here, the ligand attaches to the HER 3 receptor but the anti-tumor drug (sphere at base of the receptor) prevents the joining of HER 3 and HER 2, resulting in membrane destruction and cell death.
medical illustration of The immune system is the human body’s amazing self defense system which fights off foreign invaders that threaten the health of the human body. Cancer is a formidable invader and an aggressive challenger. It can capture the human circulatory system to feed its survival and to transport its invasion to other areas of the body. It never plays by the rules. Your move.
medical illustration of Concept art for proposed gaming project depicting cyberoid brain.
medical illustration of Anticancer drug passes through the folate carrier of the tumor cells and prevents actions that promote cell division and angiogenesis.
medical illustration of Wall mural and branding image for a rheumatologist’s private practice who wished to convey that rheumatology is not only about joints and the skeleton but also a specialty that deals with autoimmune diseases, systemic inflammatory conditions and the immune system for a holistic diagnostic approach to restore health.
medical illustration of Antitumor drugs target the intracellular component of the signaling protein receptors VEGF and MET to block tumor angiogenesis and metastasis.
medical illustration of Myelin is the electrically-insulating phospholipid sheath that surrounds the axons of many neurons and enables impulses to hop or “propagate by saltation.”
medical illustration of Myelination helps prevent the electrical current from leaving the axon and provides a potential pathway for regeneration of severed fibers.
medical illustration of Platelets are small, irregularly-shaped anuclear cells circulating in the blood to maintain hemostasis by forming blood clots when damage to the endothelium of blood vessels occurs.
medical illustration of Blood loss stimulates fibrinogen to convert fibrin strands which then trap platelets and blood cells, forming a mesh that creates a hemostatic plug over the wound site.
medical illustration of Exogenous migratory therapy techniques use stem cells to repair damaged neurons after traumatic injury or degenerative disease.
medical illustration of Multiple sclerosis (MS) is a demyelinating disease that damages the insulating membranes of nerve cells and disrupts the ability of parts of the nervous system to communicate.
medical illustration of The human cell contains numerous organelles that govern cell function, survival and reproduction.
medical illustration of Concept art for proposed interactive game depicting how man will be miniaturized and be placed into a bio-engineered “ribosome-like” vessel capable of exploring the inside of human cells. Interactive gamers explore the intracellular environment to detect the future DNA health of individual cell groups as well as diagnose and treat disease.
medical illustration of Concept art for proposed interactive game depicting how man will be miniaturized and be placed into a bio-engineered “ribosome-like” vessel capable of exploring the inside of human cells. Interactive gamers explore the intracellular environment to detect the future DNA health of individual cell groups as well as diagnose and treat disease.
medical illustration of Concept art for an interactive gaming where players explore the human body at the cellular level. The spherized DNA molecule allows players to monitor the health of the cells being investigated.
medical illustration of Macrophages present antigens of destroyed pathogens on their surfaces for T cells to retrieve and thereby initiate the immune response.
medical illustration of Cancer cells are abnormal cells that divide uncontrollably and destroy body tissue.
medical illustration of Before successful cell division can occur the genomic information stored in chromosomes must be replicated, and the duplicated genome separated cleanly between cells.
medical illustration of Unicellular organisms like bacteria grow to a fixed size and then reproduce through binary fission - a form of asexual reproduction.
medical illustration of White blood cells are diverse immune system cells that defend the body against both infectious disease and foreign materials.
medical illustration of Cytokines are signaling proteins and glycoproteins that are used extensively in cellular communication for both innate and adaptive immune responses.
medical illustration of Exogenous migratory therapy techniques use stem cells to repair damaged neurons after traumatic injury or degenerative disease. For Stanford Department of Neurosurgery, Stanford University School of Medicine.
medical illustration of Because a virus is unable to reproduce outside a host cell, blocking the cell’s replication pathway will also block replication of the virus.
medical illustration of Dry eye damages the three tear film layers (mucin, aqueous and lipid) of the normal ocular surface and causes hypertonic stress to the corneal epithelial cells.
medical illustration of Factor IX, or Christmas factor, is one of the serine proteases of the coagulation system. Deficiency of this protein causes Hemophilia B.
medical illustration of Concept art for proposed gaming project depicting cyberoid circulatory system.
medical illustration of The left coronary artery arises from the aorta above the left cusp of the aortic valve and feeds the left side of the heart.
medical illustration of Visualization of the anatomical relationship of the liver and kidneys to highlight a detoxification program.
medical illustration of DNA microarray technology analyzes reproducible and aligned array patterns to bring order to large amounts of gene data.
medical illustration of When activated, mast cells rapidly release histamine, heparin, and various hormonal mediators by degranulation to regulate allergy, anaphylaxis and wound healing.
medical illustration of When macrophages destroy pathogens they place antigens on their surfaces to stimulate the immune system. T Cells then pick up the antigens and orchestrate the immune response.
medical illustration of Transmission of the swine flu virus from pigs to humans is not common and does not always lead to human influenza, often resulting only in the production of antibodies in the blood.
medical illustration of Monoclonal antibodies are “magic bullets” bioengineered to target specific cancer cells with a toxin delivered by its agent of selectivity.
medical illustration of Because monoclonal antibodies are monospecific antibodies that are made of identical immune cells that are all clones of a unique parent cell, monoclonal antibodies have monovalent affinity and bind to the same epitope.
medical illustration of When a monoclonal antibody attaches to the surface of a targeted cell it is encapsulated and brought into the cell where it then initiates cell destruction.
medical illustration of Mapping of interventional pathways into the cell for antitumor therapy.
medical illustration of Numerous intracellular pathways of tumor cells are being explored as delivery routes for new drug therapies designed to interrupt tumor cell replication by preventing angiogenesis and cell division.
medical illustration of Destruction of virulent microbe strains is hampered by the microbe’s protective outer membrane. Stronger antimicrobial drugs are able to penetrate and destroy the outer membrane and expose the more vulnerable inner membrane.
medical illustration of Concept art depicting quinolone antibiotic attack on difficult-to-destroy pathogens.
medical illustration of After an antibiotic penetrates the tough exterior shell of a microbial cyst, the antibiotic “smart bomb” targets the inner membrane. For Alcon.
medical illustration of Nelarabine MOA for treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. For GlaxoSmithKline.
medical illustration of Normal, hyperactive, suppressed and recovering nerves. For Giant Creative.
medical illustration of Pulmonary hypertension drug therapy regimes can have negative affects on hepatocytes in the liver due to the build-up of bile salts. For Volibris® for GlaxoSmithKline.

Profile

Edmond Alexander and Cynthia Turner create original images for the pharmaceutical, biomedical technology and healthcare industries and specialize in synthesizing complex information into accurate visual science with clarity and visual impact. They are represented by Gail Thurm, Senior VP of Pharmaceutical Services, Shannon Associates LLC, NYC. More about Edmond and Cynthia at https://www.alexanderandturner.com/about

Style/Techniques

Airbrush, Color, 3D

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Cardiac Surgery / Cardiology, Cell biology / Histology, Disease Management, Emergency Medicine, Endocrinology / Metabolic, Gastroenterology, Medical Devices, Molecular Biology, Neuroscience, Neurosurgery, Ophthalmology, Pharmacology, Reproductive Biology, Respiratory, Urology, Vascular Surgery, Virology, Oncology, Mechanism of Action (MOA), Health & Wellness, Plastic Surgery