Ras is an important signalling integrator downstream of several receptor tyrosine kinases. It’s activity is tightly controlled in all eukaryotic cells, as it determines the rate of proliferation and differentiation. Consequently, aberrant ras activation, either too little or too much might cause severe diseases, including cancer, inflammatory and immunological disorders. In fact in a third of all human cancers one of the three RAS genes is mutated, where they act as prototypic oncogenes.
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