Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Mutations in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver cells and endothelial cells. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs.
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