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Boehringer Ingelheim

BI-9321 binder of NSD3

biolution

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Chromatin component NSD3 (green) binds to compound BI-9321 (red) straddling DNA on a nucleosome (yellow) in the presence of BRD4. This coverpitch for Nature Biotechnology accompanied a manuscript by Boehringer Ingelheim researchers about the activities of BI-9321.

biolution GmbH 2019

biolution

medical animation of The new coronavirus SARS-CoV-2 which can cause the coronavirus respiratory disease COVID-19. As the outbreak is now officially pandemic it is reaching a high number of countries all over the world, the general public awareness, media coverage and scientific interest are also on the rise.
medical illustration of Available structural data of SARS proteins incorporated into a realistic model for coronavirus
medical illustration of modern biophysical methods are pushing the current limits of observing the nano world. Using photonic crystal structures single-molecule biosensing applications are pushing boundaries measuring structural changes in real time.
medical illustration of Cytochrome P450 3A4 (CYP3A4) is an enzyme responsible for degrading many compounds (xenobiota). Grapefruit contains several chemicals, including bergamottin and nirangin visualised here, which bind and block the active site of CYP3A4. This can increase the level of therapeutics in patients and therefore cause severe side effects, possibly interferring with chemotherapeutics.
medical illustration of The most important concept in molecular biology is that DNA is made to RNA and RNA is made to protein. Until a few years ago regulation and appearance of the RNA polymerase was unclear, but with new methods structure could be decrypted and mechanisms clarified.
medical animation of Bacterial viruses are called phages or bacteriophages. They only attack bacteria; Phages stick to bacteria with their leg-like fibres, which triggers their shaft to ram a needle into the bacterial hull. This punctures the bacterial envelope and injects the genetic material. Phage components are assembled within the cell before it ruptures to release a new wave of phages – killing further bacteria. Researchers immediately realised phages could help to fight bacterial infections.
medical animation of William Kaelin, Peter Ratcliffe, and Gregg Semenza received the 2019 Nobel Prize for Medicine or Physiology for illuminating the molecular switch responding to hypoxia. The molecular machinery explains how multicellular animals tune their physiology to cope with varying quantities oxygen. The image shows how Heterodimeric HIF-1a:ARNT complex binding to the HRE on DNA (pdb: 4ZPR).
medical illustration of The new coronavirus SARS-CoV-2 with its main components of the virion Spike, m and e protein. All proteins are modelled from published structural data.
medical animation of There are more than 180 interventional clinical trials listed for COVID19. We summarise some of the approaches.
medical illustration of Wrongly folded Alpha-Synuclein similar to prions agglutinates, breaks through the cell wall and infects other neurons which results in the death of dopamine producing cells giving the starting shot to Parkinson’s Disease. In this picture, the disease already spread through the tissue but through a previous vaccination Macrophages attack the aggregates and stop further infection of healthy cells.
medical animation of Inspired by the the classic images of Spanish neuroscientists Ramon y Cajal and the modern connectivity maps biolution explores what we kinow about human brain organisation in this visualisation.
medical illustration of This is a scientifically accurate 3D model of the non-enveloped viral particle of the Coxsackie Virus. The virus is part of Genus Enteroviruses which are the most common and important human pathogens. Interestingly Coxsackie Viruses share many characteristics with the Polio Virus. As a result of this the Coxsackie Virus plays a key role in understanding non-polio Enteroviruses.
medical animation of Animation, Color, 3D, Models, Video, Biology, Biotechnology, Neuroscience, Reconstructive Surgery, Vascular Surgery
medical illustration of Epigenetic mechanisms contribute to many diseases, as they contribute to the age-related erosion of gene expression program as well as the establishment of aberrant transcriptional programs in pathologies. Recent research has highlighted the roles of readers of the epigenetic code, which include PWWP1-domain containing proteins. The motif binds to Histone-4 methylated at lysine-20, H4K20me, suggesting it mediates some of the downstream functions of this critical epigenetic mark.
medical animation of Most people see bacteria as bad pathogens who have to be fought, but only a few know that the majority of the bacteria are very helpful to humans. They live everywhere in and on our body in close symbiosis with us. Helping us by digestion, health and food production.
medical animation of The initiation of DNA import is not entirely clear, but once DNA, the packaging motor and pro-head interact the DNA is rapidly threaded through a pore in the circular motor at the speed of 2000 basepairs a second.
medical illustration of Wrongly folded Alpha-Synuclein similar to prions agglutinates, breaks through the cell wall and infects other neurons which results in the death of dopamine producing cells giving the starting shot to Parkinson’s Disease. In this picture, Macrophages attack the aggregates and stop further infection of healthy cells, because of a vaccination. by biolution
medical illustration of Most people see bacteria as bad pathogens who have to be fought, but only a few know that the majority of the bacteria are very helpful to humans. They live everywhere in and on our body in close symbiosis with us. Helping us by digestion, health and metabolism. The entirety of a microbial community is referred to as microbiome.
medical illustration of Bacterial viruses are called bacteriophages. They only attack bacteria; phages are harmless to people, animals, and plants. In times of growing Antibiotics resistances phages might be a useful alternative to combat multi-resistant bacteria. Here you see them attacking E. coli bacteria.
medical illustration of Neurodegenerative diseases characterised by aggregates of the protein Alpha-Synuclein are referred to by the umbrella term Alpha-Synucleinopathies. Alpha-Syn is widely expressed in the brain. There is increasing evidence that misfolded aggregated Alpha-Syn is the causative agent in Synucleinopathies, which has constituted a significant advance in our understanding of these diseases.
medical illustration of Emmanuelle Charpentier explored a mysterious bacterial mechanism, which protects bacteria from bacteriophages. This led her to discover the gene editing mechanism of CRISPR/Cas9 in Streptococcus pyogenes a bacterium known to cause bronchitis in humans. Only a few years later scientific publications are full with new and innovative applications of gene editing and almost every lab around the world uses gene editing now, exploring applications to tackle genetic diseases.
medical animation of Iodine is a micronutrient needed for the production of thyroid hormones. The thyroxine-binding globulin (TBG) is one of three transport proteins responsible for carrying thyroxine (T4) and triiodothyronine (T3) in our bloodstream. TBG is one of only three thyroid hormone-binding carriers, but differs strongly from the other two. It has the highest affinity for T4 and T3 but is present in the lowest concentration as well as having only a single binding site for T4/T3.
medical illustration of Escherichia coli are Gram-negative, facultative anaerobic, rod-shaped, coliform bacteria that are commonly found in the lower intestine of warm-blooded organisms. Most strains are harmless, but some serotypes can cause serious food poisoning in their host. The harmless strains are part of the normal microbiota of the gut, and can benefit their hosts by producing vitamin K2 and preventing colonization of the intestine with pathogenic bacteria.
medical illustration of Healthy humans live in a close and very beneficial relationship with bacteria, also called the microbiome. Bacteria are living everywhere in and on our bodies in astonishing numbers, helping us to digest our food, train our immune system and even ward of pathogens with antibiotics. Without these microscopic superheroes we would certainly be worse off. Therefore we showcase beautiful Streptococcus bacteria.
medical illustration of This is a scientifically accurate 3D model of the enveloped viral particle of the Cytomegalovirus. The virus is part of Genus Herpesviruses common in humans and monkeys.
medical illustration of Antibodies are the most important proteins for our adaptive immune system. The Y-shaped protein is a highly heterogenous group made to bind on specific antigens marking bacteria, parasites and even in special circumstances own tissue for destruction through macrophages and cytokines.
medical animation of The most important concept in molecular biology is that DNA is made to RNA and RNA is made to protein. Until a few years ago regulation and appearance of the RNA polymerase was unclear, but with new methods structure could be decrypted and mechanisms clarified.
medical illustration of Vibrios are Gram-negative bacteria, possessing a comma shaped body. Several species of cause foodborne infection, usually humans get infected by eating undercooked seafood. Surprisingly Vibrio species typically has 2 chromosomes, which is unusual for bacteria. Each chromosome has a distinct and independent origin of replication,[7] and are conserved together over time in the genus.
medical animation of HIV is a Lentivirus, part of the Retroviridae. The virion contains single-stranded RNA, wich is into the hosts genome upon retro-transcription into DNA. However, while modern therapy allows infected individuals to live a widely normal life nowadays, many challenges remain. These include stable transfection rates, access to medication including preventive medicine and suitable treatments for children.
medical illustration of Tyrosinekinase domains of EGFR/HER3 inhibited by afatinib. The main driver mutation in cancer is in the RAS gene cluster where RAS acts like a oncogene. Medicaments with ingrdients like the pan ERBB-inhibitor afatinib which binds in the tyrosine kinase domain of EGFR (red) and switches proliferative signals off stopping further tumor growth.
medical illustration of Cancer is one of the most common cause of death. Therefore, scientist have found multiple ways in their desire to destroy cancer ultimately. Going of immune or radiation therapies to the intake of cytotoxic ingrediences like Taxol or Doxorubicin by interfering at DNA synthesis and promote further mutations.
medical illustration of Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Mutations in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver cells and endothelial cells. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs.
medical animation of Ras is an important signalling integrator downstream of several receptor tyrosine kinases. It’s activity is tightly controlled in all eukaryotic cells, as it determines the rate of proliferation and differentiation. Consequently, aberrant ras activation, either too little or too much might cause severe diseases, including cancer, inflammatory and immunological disorders. In fact in a third of all human cancers one of the three RAS genes is mutated, where they act as prototypic oncogenes.
medical illustration of T cells are a highly heterogenic group of immune cells developed in the thymus. They are fulfilling various important function in our body. Special CD8+ T cells also known as cytotoxic cells can directly kill virus infected cells. While others play an important role in the adaptive immune response.
medical illustration of EcoRV is part of the family of restriction enzymes. This very diverse family is capable of producing blunt or sticky ends and cut on various specific sights. Biotechnology in research is using these enzymes to make restriction digests and analysis
medical illustration of The nucleus is the most important cell compartment. It preserves the DNA and gives a physical barrier as the RNA can be processed without ribosome interaction.
medical illustration of This is a scientifically accurate 3D model of the enveloped viral particle of the Arenavirus. It is known to cause haemorrhagic fever and meningitis in humans and is spread additionally by rodents which act as a reservoir. A few years ago, Arena Viruses also were identified in reptiles probably causing a deathly infection.
medical illustration of Cells in our bodies are constantly interacting with each other, signals pass between cells when they touch, but also long distance by soluble factors. The complexity of cell-cell interactions are increasingly addressed with “omics” approaches, investigating not isolated molecules and pathways, but their interplay on gene expression, protein modification and metabolic changes. The video was produced using the visualization platform of us developed with advice by scientists.
medical illustration of These cells are part of the immune system and have their function in antigen presentation. They are presenting the antigen material to T cells having the key role as messenger between the innate and adaptive immune system giving them the possibility of producing antibodies and attack directly the pathogen.
medical animation of Many models and diagrams show the cell surface as stiff and unmovable barrier between cells and the outside. But imagine cell membranes are an extremely thin fluid layer of a fatty substance (lipids), which forms a barrier for water soluble molecules. In addition the membrane contains proteins, which move within the fluid all the time, transporting material across the membrane or relaying signals. In our visualisation we try to give you a glimpse of the dynamics on the cell surface.
medical animation of Women with breast implants are at risk of developing a rare type of cancer known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). BIA-ALCL typically occurs in the scar tissue capsule or fluid that surrounds the implant. In some cases. Lymphomas like BIA-ALCL begin in lymphocytes. BIA-ALCL causes certain lymphocytes—known as T-cells—to mutate and grow out of control. BIA-ALCL is not considered to be a breast cancer, but a lymphoma.
medical animation of This is a scientifically accurate 3D model of the enveloped viral particle of the Cytomegalovirus. The virus is part of Genus Herpesviruses common in humans and monkeys.
medical illustration of Most tumors have the ability to hide from the immune system. Undetected by the immune system the cancer can grow and spread through the body. The new method of treatment of immunotherapy is trying to indicate that tumor tissue is noticed by the immune system having almost no side effects as only tumor cells are affected, unlike in radiation or chemotherapy.
medical illustration of Cancer has found ways to hide from the immune system to escape death. But scientist found out that a larger number of tumors are getting destroyed by the immune system in early stage. Therefore, scientists found out that most tumor cells have a modified receptor spectrum on the membrane. This knowledge is used for today’s immune therapies
medical illustration of Dendritic cells are part of the immune system and have their function in antigen presentation. As you see both cell types are strongly interacting with each other as antigen material is presented to the T cells. The dendritic cells having the key role as messenger between the innate and adaptive immune system are giving the T cells the possibility of producing antibodies and attack the pathogen directly.
medical illustration of Dendritic cells are part of the immune system and have their function in antigen presentation. As you see both cell types are strongly interacting with each other as antigen material is presented to the T cells. The dendritic cells having the key role as messenger between the innate and adaptive immune system are giving the T cells the possibility of producing antibodies and attack the pathogen directly.
medical illustration of T cells are a highly heterogenic group of immune cells developed in the thymus. They are fulfilling various important function in our body. Special CD8+ T cells also known as cytotoxic cells can directly kill virus infected cells. While others play an important role in the adaptive immune response.
medical illustration of This image is a cross section of the membranes of immune cells (t cell and b cell) showing their molecular interaction with different membrane proteins. Giving an insight into the molecular mechanisms of cell communication.
medical animation of Today cardiovascular diseases are the most common cause of death. Especially in industralised countries atheriosclerosis plays an important role in combination with high blood pressure. Causing heart attacs, strokes and thrombosis.

Profile

Biolution has assembled a visualization pipeline based on the multidisciplinary expertise of its team of biologists and media designers with extensive experience in explaining research. Our inspiration was to generate affordable animations, which are rooted in scientific accuracy and extend into inspiring dynamic visualizations. It is our ambition to support researchers in their communication tasks with a dynamic representation of their favourite molecule or molecular process. Importing coordinates from the RCSB-protein data bank into our work flow, we interact closely with researchers to develop a dynamic 3D-model of the molecule of choice. Together with the expert, we aim to develop a visualization, which meets the standards of scientific accuracy suitable for a research conference presentation and at the same time inspires a sense of wonder about the beauty of natural processes. However, we can also touch up your scientific figures or provide scientific illustrations. *For 3D-visualisations we are continuously expanding our toolset and will be keen to learn from your research towards improving our capacity to show the fascinating microcosm of molecular biology. If you require attractive images to support the communication of an outstanding research finding or seek to visualize the mode of action of a new drug candidate in a molecular animation, biolution will be ready to work with you. Inform us about your research and challenge us to visualize: Signaling processes \ Disease mechanisms \ Mode of action of drugs Contact us, if you plan to work with a competent partner, who understands your research in order to complement your communications with professional visualizations.

Style/Techniques

Animation, Black & White, Cartoon, Color, 3D, Models, Video, Microscopy

Subject/Specialties

Allergy / Immunology, Alternative Medicine, Biology, Biotechnology, Cell biology / Histology, Disease Management, Endocrinology / Metabolic, Gastroenterology, General Medicine, General Surgery, Genetics, Medical Devices, Molecular Biology, Natural Science / Nature, Neuroscience, Neurosurgery, Pharmacology, Reconstructive Surgery, Reproductive Biology, Respiratory, Transplantation Surgery, Vascular Surgery, Virology, Injuries, Oncology, Mechanism of Action (MOA), Health & Wellness, Hemophilia, Pathology, Plastic Surgery