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HIF-1a in complex with ARNT on DNA 

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Next medical illustration of The new coronavirus SARS-CoV-2 with its main components of the virion Spike, m and e protein. All proteins are modelled from published structural data.


William Kaelin, Peter Ratcliffe, and Gregg Semenza received the 2019 Nobel Prize for Medicine or Physiology for illuminating the molecular switch responding to hypoxia. The molecular machinery explains how multicellular animals tune their physiology to cope with varying quantities oxygen. The image shows how Heterodimeric HIF-1a:ARNT complex binding to the HRE on DNA (pdb: 4ZPR).

Keywords: Color, 3D, Video, Research, Biology, Biotechnology, General Medicine, Genetics, Molecular Biology, Mechanism of Action (MOA)