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Inhibition of PI3K Pathway 

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TRK Selective Inhibitor

medical illustration of Mechanism of action of Duvelisib (Copiktra); oral delta and gamma PI3K inhibitor. This dual isoform blockage inhibits cell signaling within malignant B cells and between malignant cells and the tumor microenvironment (TME). Blocking PI3K delta pathways from activated BCR, cytokine, and CD40 receptors affects the growth and survival of malignant B cells.
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Mechanism of action of Duvelisib (Copiktra); oral delta and gamma PI3K inhibitor. This dual isoform blockage inhibits cell signaling within malignant B cells and between malignant cells and the tumor microenvironment (TME). Blocking PI3K delta pathways from activated BCR, cytokine, and CD40 receptors affects the growth and survival of malignant B cells.

Keywords: Color, Editorial, Cell biology / Histology, Oncology, Mechanism of Action (MOA)

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