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TRK Selective Inhibitor 

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Pseudoprogression

medical illustration of Damage to NTRK genes can lead to fusion proteins that cause unregulated cellular growth and differentiation because signaling cascades stay activated. The main illustration shows Larotrectinib binding to a dimerized TRKC fusion protein and consequently stopping the signal cascades that would have followed (indicated by faded out proteins)
Next medical illustration of Mechanism of action of Duvelisib (Copiktra); oral delta and gamma PI3K inhibitor. This dual isoform blockage inhibits cell signaling within malignant B cells and between malignant cells and the tumor microenvironment (TME). Blocking PI3K delta pathways from activated BCR, cytokine, and CD40 receptors affects the growth and survival of malignant B cells.

Inhibition of PI3K Pathway

Damage to NTRK genes can lead to fusion proteins that cause unregulated cellular growth and differentiation because signaling cascades stay activated. The main illustration shows Larotrectinib binding to a dimerized TRKC fusion protein and consequently stopping the signal cascades that would have followed (indicated by faded out proteins)

Keywords: Color, Editorial, Publishing, Web, Professional Education, Allergy / Immunology, Cell biology / Histology, Oncology, Mechanism of Action (MOA)

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