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From somatic cell to genetically-modified pig 

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Genomewide Genetic Perturbation Screening.

medical illustration of One of a series of illustrations accompanying an article on xenotransplantation. This figure demonstrates the process of somatic cell nuclear transfer which permits derivation of genetically-modified animals, such as pigs. That process, in combination with additional ‘knock-in’ and ‘knock-out’ genes can produce organs that are less likely to elicit hyperimmune acute rejection when transferred to human recipients. N Engl J Med 2022;387:35-44.
Next medical illustration of The first step in obtaining a clone of an organism. A somatic cell (or its nucleus) is obtained from the organism and transferred into the cytoplasm of an enucleated oocyte. Subsequent steps include reprogramming of the DNA in the nucleus by oocyte factors (a passive step) and induction of cell division through delivery of electric pulses.

Somatic cell nuclear transfer

One of a series of illustrations accompanying an article on xenotransplantation. This figure demonstrates the process of somatic cell nuclear transfer which permits derivation of genetically-modified animals, such as pigs. That process, in combination with additional ‘knock-in’ and ‘knock-out’ genes can produce organs that are less likely to elicit hyperimmune acute rejection when transferred to human recipients. N Engl J Med 2022;387:35-44.

Keywords: Color, Information Graphics, Museum / Zoo, Research, Allergy / Immunology, Anatomy, Biology, Genetics, Transplantation Surgery, Zoology

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