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Periprosthetic Joint Infection 

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Thrombotic Thrombocytopenic Purpura

medical illustration of Panel A shows biofilms on the implant surface in a patient with an infected knee arthroplasty. Panel B shows common joint replacements. Panel C shows the external appearance of PJI of the knee, with swelling, erythema, a wound that is open at the bottom with drainage, and a sinus tract. Not all these clinical manifestations are present in every patient. N Engl J Med 2023; 388:251-262 DOI: 10.1056/NEJMra2203477.
Next medical animation of Series of illustrations created for a new video case series, NEJM Double Takes. This video highlights the effects of climate change on health through an illustrative patient case. Viewers are guided through the clinical presentation, differential diagnosis, laboratory studies, and treatment, culminating in the final diagnosis.

Hunting for a Diagnosis

Panel A shows biofilms on the implant surface in a patient with an infected knee arthroplasty. Panel B shows common joint replacements. Panel C shows the external appearance of PJI of the knee, with swelling, erythema, a wound that is open at the bottom with drainage, and a sinus tract. Not all these clinical manifestations are present in every patient. N Engl J Med 2023; 388:251-262 DOI: 10.1056/NEJMra2203477.

Keywords: Education, Professional Education, Anatomy, Medical Devices, Orthopaedics, Sports Medicine

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