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Thrombotic Thrombocytopenic Purpura 

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Esophagectomy

medical illustration of TTP is caused by severely low ADAMTS13 activity, leading to impaired cleavage of ultralarge von Willebrand factor multimers, platelet-rich microthrombi formation, and end-organ ischemia. TTP is characterized by a relatively lower rate of renal failure and a relatively higher rate of severe thrombocytopenia and neurologic manifestations. N Engl J Med 2022; 387:e41. https://www.nejm.org/doi/full/10.1056/NEJMimc2117464
Next medical illustration of Panel A shows biofilms on the implant surface in a patient with an infected knee arthroplasty. Panel B shows common joint replacements. Panel C shows the external appearance of PJI of the knee, with swelling, erythema, a wound that is open at the bottom with drainage, and a sinus tract. Not all these clinical manifestations are present in every patient. N Engl J Med 2023; 388:251-262 DOI: 10.1056/NEJMra2203477.

Periprosthetic Joint Infection

TTP is caused by severely low ADAMTS13 activity, leading to impaired cleavage of ultralarge von Willebrand factor multimers, platelet-rich microthrombi formation, and end-organ ischemia. TTP is characterized by a relatively lower rate of renal failure and a relatively higher rate of severe thrombocytopenia and neurologic manifestations. N Engl J Med 2022; 387:e41. https://www.nejm.org/doi/full/10.1056/NEJMimc2117464

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