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Trypanosoma brucei 

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Disease progression: healthy to chronic lymphedema

medical illustration of A protozoan parasite transmitted by the blood-feeding flies of the genus glossina (the tsetse fly), a vector that is widespread in sub-Saharan Africa. This parasite causes African trypanosomiasis (sleeping sickness), which is characterized by severe swelling of the lymph nodes, poor sleep, and neurologic, cognitive and psychiatric symptoms. In the absence of treatment, trypanosomiasis is fatal.
Next medical illustration of Shown is the process of detecting fetal trisomy with the use of cell-free DNA (cfDNA) in maternal plasma.The fragments are sequenced and aligned to a reference set of chromosome sequences. A counting process is then used to determine the relative amount of cfDNA from each chromosome and to investigate whether any are overrepresented. Overrepresentation of sequences from chromosome 21 suggests that the fetus has trisomy 21. N Engl J Med 2022; 387:1322-1324 DOI: 10.1056/NEJMcibr2209405

Use of Cell-free DNA in Maternal Plasma

A protozoan parasite transmitted by the blood-feeding flies of the genus glossina (the tsetse fly), a vector that is widespread in sub-Saharan Africa. This parasite causes African trypanosomiasis (sleeping sickness), which is characterized by severe swelling of the lymph nodes, poor sleep, and neurologic, cognitive and psychiatric symptoms. In the absence of treatment, trypanosomiasis is fatal.

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