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Lila Strohl

Lila Strohl

Innate Immunity MOA for Anti-CD47 Antibodies

Macrophages Attacking S. pneumoniae

medical illustration of Proposed innate immunity mechanism of action for anti-CD47 antibodies. Blocking the
CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

medical illustration of Three signals dominate the

Interaction of an APC with a Cancer Cell

Proposed innate immunity mechanism of action for anti-CD47 antibodies. Blocking the CD47/SIRP-a “don’t eat me” signal between tumor cells and antigen-presenting phagocytic cells (APCs) results in phagocytosis of the tumor cell and cross-presentation of antigens derived from the tumor cell via MHC class I to T cells, which then are induced to produce apoptotic factors that can kill tumor cells directly.

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Molecular Biology, Oncology, Mechanism of Action (MOA)

© Lila Strohl, CMI