Three signals dominate the "eat me, don't eat me" response. Two of the signals, an anti-tumor antibody linked to the phagocyte via FcgR11a and calreticulin binding to LRP1, are pro-phagocytic, "eat me", signals. And CD47 binding to SIRP-a is an anti-phagocytic, "don't eat me", signal. When the CD47/SIRP-a signal is disrupted with an anti-CD47 antibody, the result is a pro-phagocytic, "eat me", response to the tumor cell.
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© Lila Strohl, CMI