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Interaction of an APC with a Cancer Cell 

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Innate Immunity MOA for Anti-CD47 Antibodies

medical illustration of Three signals dominate the
Next medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Blocking CD47/SIRP-a Interaction

Three signals dominate the "eat me, don't eat me" response. Two of the signals, an anti-tumor antibody linked to the phagocyte via FcgR11a and calreticulin binding to LRP1, are pro-phagocytic, "eat me", signals. And CD47 binding to SIRP-a is an anti-phagocytic, "don't eat me", signal. When the CD47/SIRP-a signal is disrupted with an anti-CD47 antibody, the result is a pro-phagocytic, "eat me", response to the tumor cell.

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© Lila Strohl, CMI