SerbinCreative

(805) 963-0439 | Toll-Free (800) 876-6425

www.serbincreative.com LA / NY / UK

Interaction of an APC with a Cancer Cell 

Prev Next
Previous

Innate Immunity MOA for Anti-CD47 Antibodies

medical illustration of Three signals dominate the
Next medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

Blocking CD47/SIRP-a Interaction

Three signals dominate the "eat me, don't eat me" response. Two of the signals, an anti-tumor antibody linked to the phagocyte via FcgR11a and calreticulin binding to LRP1, are pro-phagocytic, "eat me", signals. And CD47 binding to SIRP-a is an anti-phagocytic, "don't eat me", signal. When the CD47/SIRP-a signal is disrupted with an anti-CD47 antibody, the result is a pro-phagocytic, "eat me", response to the tumor cell.

Keywords: Color, Information Graphics, Publishing, Web, Professional Education, Research, Biotechnology, Cell biology / Histology, Molecular Biology, Mechanism of Action (MOA)

© Lila Strohl, CMI