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Blocking CD47/SIRP-a Interaction 

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Interaction of an APC with a Cancer Cell

medical illustration of SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal).  Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).
Next medical illustration of Antagonist IgG antibody binding to the immuno-oncology checkpoint target, PD-1, to reinvigorate exhausted T cells

Antagonist IgG Antibody binding to PD-1

SIRP-a, which is on the surface of phagocytes, normally binds CD47 on the surface of normal and tumor cells as a signal to prevent phagocytosis (often referred to as the “don’t eat me” signal). Blocking the CD47/SIRP-a interaction with a monoclonal antibody can result in a pro-phagocytic response (i.e., the cancer cells can become phagocytized).

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