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Celsion Corporation

DNA vaccine method of action

Jane Whitney

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Viral antigen is presented on the surface of the APC cell, activating the T cell response and a strong immune response against the SARS-CoV2 spike protein.

Celsion

Jane Whitney

AMI #28

Page 158

Jane Whitney

AMI #27

Page 148

Jane Whitney

AMI #26

Page 151

Jane Whitney

AMI #25

Page 178

Jane Whitney

AMI #23

Page 179

Jane Whitney

AMI #22

Page 20

Jane Whitney

medical illustration of CMI logo
medical illustration of The SARS-CoV-2 virus, which causes the COVID-19 disease. The spike on the virus binds to the ACE2 receptor on the surface of the alveolar type 2 cell in the lung.
medical illustration of Antigen-Presenting-Cells process antigens and present them to T-cells. The internalized antigen is digested into smaller peptides, which are then presented to T cells by the MHC. The antigen, here a SAR-CoV-2 spike, can be 1. phagocytosed by the cell, or 2. the DNA encoding the spike can be brought into the cell where the spike protein is made then digested.
medical illustration of This Covid-19 vaccine contains mRNA encoding for the spike protein of the virus, inside a liponanoparticle which mimics low-density lipoproteins, and allows them to be taken up by the cells. Once in the cytoplasm, the spike protein is manufactured through normal cell mechanisms and an antigen is presented on the cell surface for the immune system to recognize and mount a response.
medical illustration of SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected up to 72 hours after application to these surfaces. On copper, no viable SARS-CoV-2 was measured after 4 hours.. On cardboard, no viable SARS-CoV-2 was measured after 24 hours. Source: Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. v. Doremalen and Others. March 17, 2020, at NEJM.org
medical illustration of Pneumorrhachis: The most frequent initial mechanism is an increase in intraalveolar pressure (acute asthma, recurrent vomiting, or closed thoracic trauma). Barotrauma and alveolar rupture allow air migration along the bronchial tree up to the mediastinum. The collected air then separates the mediastinal pleura from the aorta and the parietal pleura from the spine; therefore, it enters the epidural space via the intervertebral foramina.
medical illustration of In rare cases the embryonic foramen caecum is not obliterated and the dural diverticulum does not retract. In this pediatric case an intracranial connection required surgery to remove the tract and 2 cysts.
medical illustration of An illustration for a patient book for the drug Abraxane, for the treatment of pancreatic cancer.
medical illustration of LH-stimulated changes in capillary growth and leukocyte delivery in the ovulatory follicle. Immune cells are present in the ovarian vasculature and theca interna of the preovulatory follicle (top). New vessels and breakdown of the granulosa cell basal lamina provide points of entry for circulating leukocytes (center). Additional leukocytes are seen in the granulosa cell layer prior to ovulation (bottom). Leukocyte-secreted chemokines and cytokines increase as ovulation approaches.
medical illustration of Cover illustration, June 2020, Journal of Neurosurgery: Pediatrics. A spinal extradural arachnoid cyst (SEAC) results from a rare small defect of the dura matter.
medical illustration of Procedure for drainage of a cyst in the third ventricle. The peel apart introducer allows a catheter to be inserted after the endoscope has been used to visualize the path and create a hole in the cyst. Then the catheter can be inserted.
medical illustration of Menstruation occurs after the functionalis layer of endometrium separates from the basalis. It is plausible to hypothesize that the separation between the two layers at a relatively superficial plane may lessen the likelihood of heavy bleeding or travel of stem cells into the pelvic cavity. Separation at a deeper plane, however, may favor the endometriosis phenotype.
medical illustration of Drawing of a section of the seminiferous tubule, showing the testosterone-producing Leydig cells, supporting Sertoli cells and the developing sperm. As cells mature, they progress toward the lumen of the seminiferous tubule.
medical illustration of The most common position of the uterus is anteverted (cervix angles forward) and anteflexed (body is flexed forward). A retroverted uterus is angled slightly posterior.
medical illustration of About 5–6 days post-fertilization the blastocyst usually reaches the uterus, and begins to embed into the endometrium of the uterine wall. The blastocyst possesses an inner cell mass which subsequently forms the embryo.
medical illustration of OmniPod tubeless “patch pump”
medical illustration of Insulin pumps are indicated for the continuous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin.
medical illustration of Endoscopic approach to the posterior fossa.
medical illustration of Schematic overview of the human hypothalamus. Craniopharyngiomas most likely arise from epithelial remnants of the craniopharyngeal duct or the Rathke pouch (light yellow bar). The hypothalamus consists of many hypothalamic nuclei, which are all highly connected through neural pathways. The connection between the arcuate nucleus and paraventricular nucleus (PVN) is emphasized.
medical illustration of An illustration of the general anatomy of the tentorium and relationships with the sinuses and skull.
medical illustration of One in a series of 30 illustrations for a training manual for Remodulin. The illustrations show step by step how to fill a Remodulin pump.
medical illustration of One in a series of 30 illustrations for a training manual for Remodulin. The illustrations show step by step how to fill a Remodulin pump.
medical illustration of Eye section showing the cornea, iris, and lens, for a grade 8 science textbook.
medical illustration of In this procedure the stapes is cut, leaving the foot plate. A hole is drilled in the foot plate and a prosthetic stapes is attached to the incus.
medical illustration of Anatomy and surgical approach in endoscopic third ventriculostomy for the relief of hydrocephalus.
medical illustration of Locations of pediatric brainstem gliomas
medical illustration of Brighter Than You Think is about those Eureka! or Aha! moments. Intelligent memory is needed in creative or critical thinking, and used in creating more sophisticated thinking. It is about making creative connections - connecting the dots - connecting pieces of information to come up with an idea.
medical illustration of The vocal tract, mid-sagittal view, for Dr. Kay Norton's book
medical illustration of Color, Education, Web, Anatomy, Biology, Embryology
medical illustration of Development of the embryonic urinary system at 5 weeks.
medical illustration of The celiac artery and its branches.
medical illustration of Location and basic structure of the pancreas.
medical illustration of Anatomy of the brain, including cortex, anterior cingulate gyrus, insula, thalamus, amygdala, hippocampus, and periaqueductal gray. For the book Untangling the Mind: Why We Behave the Way We Do; HarperCollins.
medical illustration of Muscles of the anterior abdominal wall.
medical illustration of Anatomy of the back and gluteal muscles.
medical illustration of Color, Education, Web, Biology, Cell biology / Histology, Genetics, Molecular Biology, Natural Science / Nature
medical illustration of Color, Education, Web, Biology, Embryology, Genetics
medical illustration of Color, 3D, Education, Web, Cell biology / Histology, Molecular Biology
medical illustration of Color, Education, Web, Anatomy, Biology, General Medicine
medical illustration of Color, Education, Web, Anatomy, Cardiac Surgery / Cardiology, General Medicine
medical illustration of Color, Education, Web, Cell biology / Histology, Molecular Biology
medical illustration of Color, Education, Web, Cell biology / Histology, Endocrinology / Metabolic, Molecular Biology
medical illustration of Color, 3D, Education, Publishing, Web, Biology, Cell biology / Histology, Molecular Biology
medical illustration of Color, Education, Publishing, Anatomy, Biology, Neuroscience
medical illustration of Color, Line with Color, Education, Biology, Genetics
medical illustration of Color, Education
medical illustration of Color, Education, Publishing
medical illustration of Black & White, Line, Education, Publishing, Biology
medical illustration of Repair of giant anterior skull base encephalocele containing intralesional eloquent brain

Profile

Jane Whitney CMI has been providing professional medical and scientific illustration services for journals, education, and patient information since 1988. Her illustration style focuses first on clarity, explaining concepts and structures in the best possible way for her client’s audience. Jane uses Adobe Illustrator and Photoshop for her digital illustrations. Jane also provides art development editing services. Her combination of art and scientific knowledge have bridged communication between the editorial team and illustrator/animator for Pearson Education, the cementbloc, and WiseWire. Based in Toronto, Jane’s client list includes educational publishers and ad agencies both in Canada and the United States. Education: Ontario College of Art and Design. B.Sc., Art as Applied to Medicine, University of Toronto, 1988. Certified Medical Illustrator, 2016.

Style/Techniques

Black & White, Color, Information Graphics, Line, Line with Color, 3D

Subject/Specialties

Allergy / Immunology, Anatomy, Biology, Biotechnology, Cardiac Surgery / Cardiology, Cell biology / Histology, Disease Management, Embryology, Endocrinology / Metabolic, Gastroenterology, General Medicine, General Surgery, Genetics, Maternal / Child, Medical Devices, Molecular Biology, Natural Science / Nature, Neuroscience, Neurosurgery, Obstetrics / Gynecology, Ophthalmology, Pediatrics, Pharmacology, Reconstructive Surgery, Reproductive Biology, Urology, Virology, Injuries, Oncology, Mechanism of Action (MOA), Health & Wellness, Plastic Surgery