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Model of SARS-CoV-2 Targeted by Antibodies 

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IgM Antibody Simultaneously Binding CD20 and CD3

medical illustration of A model of the surface of a SARS-CoV-2 virion showing SARS-CoV-2 spike proteins with one open RBD or all closed RDBs based on PDB ID 6VYB and 6VXX, respectively. The antibodies shown include IgGs (PDB ID 1IGT) crosslinking two spikes and an IgM (based on PDB ID 2RCJ) binding to multiple spikes. Also depicted is a domain antibody trimeric VHH-Fc fusion protein (based on PDB IDs 6ZXN and 1IGT) cross-linking spikes and individual VHHs (PDB ID 6ZXN) binding to RBDs with no cross-linking ability.
Next medical illustration of Macrophages attacking S. pneumoniae in pulmonary alveoli

Macrophages Attacking S. pneumoniae

A model of the surface of a SARS-CoV-2 virion showing SARS-CoV-2 spike proteins with one open RBD or all closed RDBs based on PDB ID 6VYB and 6VXX, respectively. The antibodies shown include IgGs (PDB ID 1IGT) crosslinking two spikes and an IgM (based on PDB ID 2RCJ) binding to multiple spikes. Also depicted is a domain antibody trimeric VHH-Fc fusion protein (based on PDB IDs 6ZXN and 1IGT) cross-linking spikes and individual VHHs (PDB ID 6ZXN) binding to RBDs with no cross-linking ability.

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© Lila Strohl